“Glutarate—CoA ligase”的意思、由来-开放百科全书

词条

Glutarate—CoA ligase

释义

References

{{enzyme
| Name = glutarate-CoA ligase
| EC_number = 6.2.1.6
| CAS_number = 9023-68-1
| IUBMB_EC_number = 6/2/1/6
| GO_code = 0047948
| image =
| width =
| caption =
}}

In enzymology, a glutarate-CoA ligase ({{EC number|6.2.1.6}}) is an enzyme that catalyzes the chemical reaction

ATP + glutarate + CoA ADP + phosphate + glutaryl-CoA

The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.

References

{{cite journal | vauthors = Menon GK, Friedman DL, Stern JR | year = 1960 | title = Enzymic synthesis of glutaryl-coenzyme A | journal = Biochim. Biophys. Acta | volume = 44 | pages = 375–377 | doi = 10.1016/0006-3002(60)91583-3 | pmid=13769477}}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Glutarate-CoA ligase}}{{ligase-stub}}

2 : EC 6.2.1|Enzymes of unknown structure

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