“Glutathione—CoA-glutathione transhydrogenase”的意思、由来-开放百科全书

词条

Glutathione—CoA-glutathione transhydrogenase

释义

References

{{enzyme
| Name = glutathione-CoA—glutathione transhydrogenase
| EC_number = 1.8.4.3
| CAS_number = 37256-48-7
| IUBMB_EC_number = 1/8/4/3
| GO_code = 0047140
| image =
| width =
| caption =
}}

In enzymology, a glutathione—CoA-glutathione transhydrogenase ({{EC number|1.8.4.3}}) is an enzyme that catalyzes the chemical reaction

CoA + glutathione disulfide CoA-glutathione + glutathione

Thus, the two substrates of this enzyme are CoA and glutathione disulfide, whereas its two products are CoA-glutathione and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is CoA:glutathione-disulfide oxidoreductase. Other names in common use include glutathione-coenzyme A glutathione disulfide transhydrogenase, glutathione-coenzyme A glutathione disulfide transhydrogenase, glutathione coenzyme A-glutathione transhydrogenase, glutathione:coenzyme A-glutathione transhydrogenase, coenzyme A:oxidized-glutathione oxidoreductase, and coenzyme A:glutathione-disulfide oxidoreductase. This enzyme participates in cysteine metabolism and glutathione metabolism.

References

{{cite journal | vauthors = Chang SH, Wilken DR | year = 1966 | title = Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl-disulfide interchange. I Partial purification and properties of the bovine kidney enzyme | journal = J. Biol. Chem. | volume = 241 | pages = 4251–60 | pmid = 5924646 | issue = 18 }}

{{Sulfur oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Glutathione-CoA-glutathione transhydrogenase}}{{1.8-enzyme-stub}}

2 : EC 1.8.4|Enzymes of unknown structure

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