- References
| Name = glycine formimidoyltransferase
| EC_number = 2.1.2.4
| CAS_number = 9029-84-9
| IUBMB_EC_number = 2/1/2/4
| GO_code = 0030408
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In enzymology, a glycine formimidoyltransferase ({{EC number|2.1.2.4}}) is an enzyme that catalyzes the chemical reaction
5-formimidoyltetrahydrofolate + glycinetetrahydrofolate + N-formimidoylglycine
Thus, the two substrates of this enzyme are 5-formimidoyltetrahydrofolate and glycine, whereas its two products are tetrahydrofolate and N-formimidoylglycine.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism and one carbon pool by folate.
References
- {{cite journal |author1 = Rabinowitz JC |author2 =Pricer WE | date = 1956 | title = Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid | journal = J. Am. Chem. Soc. | volume = 78 | pages = 5702–5704 | doi = 10.1021/ja01602a073 | issue = 21 }}
- {{cite journal |author1 = Rabinowitz JC |author2 =Pricer WE | date = 1957 | title = Formation, isolation and properties of 5-formiminotetrahydrofolic acid | journal = Fed. Proc. | volume = 16 | pages = 236 }}
- {{cite journal | vauthors = Sagers RD, Beck JV, Gruber W, Gunsalus IC |author-link4=Irwin Gunsalus | date = 1956 | title = A tetrahydrofolic acid linked formimino transfer enzyme | journal = J. Am. Chem. Soc. | volume = 78 | pages = 694–695 | doi = 10.1021/ja01584a054 }}
2 : EC 2.1.2|Enzymes of unknown structure