| 词条 | Glycolipid transfer protein |
| 释义 |
| Symbol = GLTP | Name = Glycolipid transfer protein (GLTP) | image = PDB 1swx EBI.jpg | width = | caption = | Pfam= PF08718 | InterPro= IPR014830 | SMART= | Prosite = | SCOP = | TCDB = | OPM family= 84 | OPM protein= 1swx | PDB= }}Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1][2] It was discovered by Raymond J. Metz and Norman S. Radin in 1980 and partially purified and characterized in 1982.[3][4] Recent reviews on structure and possible function are available.[5][6] This protein transports primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart. Human proteins containing this domainGLTP; PLEKHA8; PLEKHA9; References1. ^{{cite journal | vauthors = Rao CS, Lin X, Pike HM, Molotkovsky JG, Brown RE | title = Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses | journal = Biochemistry | volume = 43 | issue = 43 | pages = 13805–15 | date = November 2004 | pmid = 15504043 | pmc = 2596630 | doi = 10.1021/bi0492197 }} {{membrane-protein-stub}}2. ^{{cite journal | vauthors = Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA | title = Structural evidence for adaptive ligand binding of glycolipid transfer protein | journal = Journal of Molecular Biology | volume = 355 | issue = 2 | pages = 224–36 | date = January 2006 | pmid = 16309699 | doi = 10.1016/j.jmb.2005.10.031 }} 3. ^{{cite journal | vauthors = Metz RJ, Radin NS | title = Glucosylceramide uptake protein from spleen cytosol | journal = The Journal of Biological Chemistry | volume = 255 | issue = 10 | pages = 4463–7 | date = May 1980 | pmid = 7372587 | url = http://www.jbc.org/content/255/10/4463.long }} 4. ^{{cite journal | vauthors = Metz RJ, Radin NS | title = Purification and properties of a cerebroside transfer protein | journal = The Journal of Biological Chemistry | volume = 257 | issue = 21 | pages = 12901–7 | date = November 1982 | pmid = 7130186 | url = http://www.jbc.org/content/257/21/12901.long }} 5. ^{{cite journal | vauthors = Mattjus P | title = Glycolipid transfer proteins and membrane interaction | journal = Biochimica et Biophysica Acta | volume = 1788 | issue = 1 | pages = 267–72 | date = January 2009 | pmid = 19007748 | doi = 10.1016/j.bbamem.2008.10.003 }} 6. ^{{cite journal | vauthors = Brown RE, Mattjus P | title = Glycolipid transfer proteins | journal = Biochimica et Biophysica Acta | volume = 1771 | issue = 6 | pages = 746–60 | date = June 2007 | pmid = 17320476 | pmc = 1986823 | doi = 10.1016/j.bbalip.2007.01.011 }} 3 : Peripheral membrane proteins|Water-soluble transporters|Protein domains |
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