“Glycosylphosphatidylinositol diacylglycerol-lyase”的意思、由来-开放百科全书

词条

Glycosylphosphatidylinositol diacylglycerol-lyase

释义

References

{{enzyme
| Name = glycosylphosphatidylinositol diacylglycerol-lyase
| EC_number = 4.6.1.14
| CAS_number = 129070-68-4
| IUBMB_EC_number = 4/6/1/14
| GO_code = 0047396
| image =
| width =
| caption =
}}

In enzymology, a glycosylphosphatidylinositol diacylglycerol-lyase ({{EC number|4.6.1.14}}) is an enzyme that catalyzes the chemical reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and two products, 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]. Other names in common use include (glycosyl)phosphatidylinositol-specific phospholipase C, GPI-PLC, GPI-specific phospholipase C, VSG-lipase, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and diacylglycerol-lyase (1,2-cyclic-phosphate-forming).

References

{{cite journal |vauthors=Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT|authorlink5=Paul Englund | date = 1986 | title = A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein | journal = J. Biol. Chem. | volume = 261 | pages = 13813–9 | pmid = 3759991 | issue = 29 }}
{{cite journal |vauthors=Carnall N, Webb H, Carrington M | date = 1997 | title = Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei | journal = Mol. Biochem. Parasitol. | volume = 90 | pages = 423–32 | pmid = 9476790 | doi = 10.1016/S0166-6851(97)00177-1 | issue = 2 }}
{{cite journal |vauthors=Armah DA, Mensa-Wilmot K | date = 2000 | title = Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei | journal = J. Biol. Chem. | volume = 275 | pages = 19334–42 | pmid = 10764777 | doi = 10.1074/jbc.M001798200 | issue = 25 }}

{{Phosphorus-oxygen lyases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Glycosylphosphatidylinositol Diacylglycerol-Lyase}}{{enzyme-stub}}

2 : EC 4.6.1|Enzymes of unknown structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。