| 释义 |
- Interactive pathway map
- Interactions
- References
- Further reading
{{Infobox_gene}}Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[1][2] Interactive pathway map {{NicotineDopaminergicActivity_WP1602|highlight=GNAI1}} Interactions GNAI1 has been shown to interact with: {{div col|colwidth=20em}}- GPR143,[3]
- RGS12,[4]
- RGS14,[4][5]
- RGS19,[6][7]
- RIC8A,[8] and
- S1PR1.[9]
{{Div col end}} References 1. ^{{cite journal | vauthors = Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M | title = Human cDNA clones for an alpha subunit of Gi signal-transduction protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 15 | pages = 5115–9 | date = Aug 1987 | pmid = 3110783 | pmc = 298804 | doi = 10.1073/pnas.84.15.5115 }}
2. ^{{cite web | title = Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2770| accessdate = }}
3. ^{{cite journal | vauthors = Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A | title = Ocular albinism: evidence for a defect in an intracellular signal transduction system | journal = Nature Genetics | volume = 23 | issue = 1 | pages = 108–12 | date = Sep 1999 | pmid = 10471510 | doi = 10.1038/12715 }}
4. ^1 {{cite journal | vauthors = Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP | title = RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29275–81 | date = Aug 2001 | pmid = 11387333 | doi = 10.1074/jbc.M103208200 }}
5. ^{{cite journal | vauthors = Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP | title = Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits | journal = Nature | volume = 416 | issue = 6883 | pages = 878–81 | date = Apr 2002 | pmid = 11976690 | doi = 10.1038/416878a }}
6. ^{{cite journal | vauthors = Woulfe DS, Stadel JM | title = Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP | journal = The Journal of Biological Chemistry | volume = 274 | issue = 25 | pages = 17718–24 | date = Jun 1999 | pmid = 10364213 | doi = 10.1074/jbc.274.25.17718}}
7. ^{{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15203–8 | date = Dec 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203}}
8. ^{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8356–62 | date = Mar 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}
9. ^{{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9 | date = May 1996 | pmid = 8626678 | doi = 10.1074/jbc.271.19.11272}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Sidhu A, Niznik HB | title = Coupling of dopamine receptor subtypes to multiple and diverse G proteins | journal = International Journal of Developmental Neuroscience | volume = 18 | issue = 7 | pages = 669–77 | date = Nov 2000 | pmid = 10978845 | doi = 10.1016/S0736-5748(00)00033-2 }}
- {{cite journal | vauthors = Brown EJ, Frazier WA | title = Integrin-associated protein (CD47) and its ligands | journal = Trends in Cell Biology | volume = 11 | issue = 3 | pages = 130–5 | date = Mar 2001 | pmid = 11306274 | doi = 10.1016/S0962-8924(00)01906-1 }}
- {{cite journal | vauthors = Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN | title = Multiplicity of mechanisms of serotonin receptor signal transduction | journal = Pharmacology & Therapeutics | volume = 92 | issue = 2-3 | pages = 179–212 | year = 2002 | pmid = 11916537 | doi = 10.1016/S0163-7258(01)00169-3 }}
- {{cite journal | vauthors = Jiang M, Pandey S, Tran VT, Fong HK | title = Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 9 | pages = 3907–11 | date = May 1991 | pmid = 1902575 | pmc = 51562 | doi = 10.1073/pnas.88.9.3907 }}
- {{cite journal | vauthors = Gennity JM, Siess W | title = Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets | journal = The Biochemical Journal | volume = 279 ( Pt 3) | issue = Pt 3 | pages = 643–50 | date = Nov 1991 | pmid = 1953657 | pmc = 1151493 | doi = }}
- {{cite journal | vauthors = Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y | title = Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs | journal = The Journal of Biological Chemistry | volume = 263 | issue = 14 | pages = 6656–64 | date = May 1988 | pmid = 2834384 | doi = }}
- {{cite journal | vauthors = Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC | title = The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus | journal = American Journal of Human Genetics | volume = 42 | issue = 6 | pages = 884–8 | date = Jun 1988 | pmid = 3130752 | pmc = 1715192 | doi = }}
- {{cite journal | vauthors = Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M, Nozawa Y | title = GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin | journal = FEBS Letters | volume = 237 | issue = 1-2 | pages = 113–7 | date = Sep 1988 | pmid = 3139448 | doi = 10.1016/0014-5793(88)80182-0 }}
- {{cite journal | vauthors = Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y | title = Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein | journal = Biochemical and Biophysical Research Communications | volume = 202 | issue = 2 | pages = 1188–95 | date = Jul 1994 | pmid = 7914078 | doi = 10.1006/bbrc.1994.2054 }}
- {{cite journal | vauthors = Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T, Yumura W, Nihei H | title = Identification of GTP-binding proteins in human glomeruli | journal = Nihon Jinzo Gakkai Shi | volume = 36 | issue = 1 | pages = 9–12 | date = Jan 1994 | pmid = 8107314 | doi = }}
- {{cite journal | vauthors = Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, Reisine T | title = Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation | journal = Molecular Pharmacology | volume = 45 | issue = 4 | pages = 587–90 | date = Apr 1994 | pmid = 8183236 | doi = }}
- {{cite journal | vauthors = Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A | title = Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy | journal = Endocrinology | volume = 132 | issue = 6 | pages = 2484–90 | date = Jun 1993 | pmid = 8504751 | doi = 10.1210/en.132.6.2484 }}
- {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 116–20 | date = Jan 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 }}
- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9 | date = May 1996 | pmid = 8626678 | doi = 10.1074/jbc.271.19.11272 }}
- {{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15203–8 | year = 1997 | date = Dec 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203 }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Popov S, Yu K, Kozasa T, Wilkie TM | title = The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 14 | pages = 7216–20 | date = Jul 1997 | pmid = 9207071 | pmc = 23796 | doi = 10.1073/pnas.94.14.7216 }}
- {{cite journal | vauthors = Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI | title = RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells | journal = Journal of Neurochemistry | volume = 70 | issue = 5 | pages = 1964–72 | date = May 1998 | pmid = 9572280 | doi = 10.1046/j.1471-4159.1998.70051964.x }}
{{refend}}{{Intracellular signaling peptides and proteins}}{{PDB Gallery|geneid=2770}}{{GTPases}} |