| 词条 | Goitrogen |
| 释义 |
}}Goitrogens are substances that disrupt the production of thyroid hormones by interfering with iodine uptake in the thyroid gland. This triggers the pituitary to release thyroid-stimulating hormone (TSH), which then promotes the growth of thyroid tissue, eventually leading to goiter.[1] Goitrogenic drugs and chemicalsChemicals that have been shown to have goitrogenic effects include:
Goitrogenic foodsFoods which have been demonstrated to have goitrogenic effects include Soy, Cassava (when crushed and not detoxified by soaking,[8]) vegetables in the genus Brassica (such as broccoli and cabbage),[9]{{page needed|date=September 2014}} and other cruciferous vegetables.[10] See also
References1. ^{{cite book|last1=Bender|first1=David A.|title=A dictionary of food and nutrition|date=2009|publisher=Oxford University Press|location=Oxford|isbn=9780199234875|edition=3rd|url=http://www.oxfordreference.com/view/10.1093/acref/9780199234875.001.0001/acref-9780199234875-e-2463|chapter=Goitrogens}} 2. ^{{cite journal|title=Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation|url=https://www.researchgate.net/publication/20235459_Goitrogenic_effects_in_offspring_of_swine_fed_sulfadimethoxine_and_ormetoprim_in_late_gestation}} 3. ^{{cite journal|title=Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study| pmc=2780286 | pmid=19843064 | doi=10.1111/j.1365-2125.2009.03495.x| volume=68| year=2009| author=Rosenfeld H, Ornoy A, Shechtman S, Diav-Citrin O| journal=Br J Clin Pharmacol| pages=609–17}} 4. ^{{cite journal |title=Perchlorate Clinical Pharmacology and Human Health: A Review | pmc=3640367 | pmid=11477312 | volume=23 | year=2001 | author=Soldin OP, Braverman LE, Lamm SH | journal=Ther Drug Monit | pages=316–31 | doi=10.1097/00007691-200108000-00002}} 5. ^{{cite journal|title=Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention| pmc=4034507 | pmid=24895606 | doi=10.1155/2014/741018| volume=2014| year=2014| author=Andreucci M, Solomon R, Tasanarong A| journal=Biomed Res Int| page=741018}} 6. ^{{cite journal |vauthors=Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G |title=A review of mechanisms underlying anticarcinogenicity by brassica vegetables |journal=Chem. Biol. Interact. |volume=103 |issue=2 |pages=79–129 |date=February 1997 |pmid=9055870 |doi= 10.1016/S0009-2797(96)03745-3|url=http://linkinghub.elsevier.com/retrieve/pii/S0009-2797(96)03745-3}} 7. ^{{cite journal |vauthors=Erdogan MF |title=Thiocyanate overload and thyroid disease |journal=BioFactors |volume=19 |issue=3–4 |pages=107–11 |year=2003 |pmid=14757960 |doi= 10.1002/biof.5520190302|type=Review}} 8. ^1 {{cite journal |author=Vanderpas J |title=Nutritional epidemiology and thyroid hormone metabolism |journal=Annu. Rev. Nutr. |volume=26 |issue= |pages=293–322 |year=2006 |pmid=16704348 |doi=10.1146/annurev.nutr.26.010506.103810}} 9. ^{{cite book |author1=Mitchell, Richard Sheppard |author2=Kumar, Vinay |author3=Abbas, Abul K. |author4=Fausto, Nelson |title=Robbins Basic Pathology|publisher=Saunders |location=Philadelphia |year= |pages= |isbn=1-4160-2973-7 |oclc= |doi=|edition=8th}} 10. ^{{cite journal|last1=Gaitan|first1=Eduardo|title=Goitrogens in Food and Water|journal=Annual Review of Nutrition|date=July 1990|volume=10|issue=1|pages=21–37|doi=10.1146/annurev.nu.10.070190.000321|pmid=1696490}} External links
1 : Thyroid disease |
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