Grand Opera House may refer to:

in Canada

• Grand Opera House (Toronto)

in England

• Grand Opera House (York)

in France

• Palais Garnier in Paris, often called the "Grand Opera House"

in Northern Ireland

• Grand Opera House (Belfast)

in the United States

• Grand Opera House (Pueblo, Colorado), designed by Adler and Sullivan
• Grand Opera House (Wilmington, Delaware)
• Degive's Grand Opera House, Atlanta, Georgia, listed on the NRHP in Fulton County, Georgia
• Grand Opera House (Macon, Georgia), listed on the NRHP in Georgia
• Beardstown Grand Opera House, Beardstown, Illinois, NRHP-listed, in Cass County
• Grand Opera House (Dubuque, Iowa), NRHP-listed
• Brown Grand Opera House, Concordia, Kansas, listed on the NRHP in Kansas
• Grand Opera House (St. James, Minnesota), NRHP-listed, in Watonwan County
• Grand Opera House (Meridian, Mississippi), NRHP-listed
• Grand Opera House (Manhattan), New York City
• Vale Hotel and Grand Opera House, Vale, Oregon, listed on the NRHP in Oregon
• Grand 1894 Opera House (Galveston, Texas), NRHP-listed
• Grand Opera House (Uvalde, Texas), NRHP-listed
• Grand Opera House (Seattle, Washington)
• Grand Opera House (Ashland, Wisconsin)
• Oshkosh Grand Opera House, Oshkosh, Wisconsin, listed on the NRHP in Winnebago County, Wisconsin

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