1. Structure

2. Signal transduction

3. References

4. Further reading

5. External links

The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.^[1]

It is associated with Surfactant metabolism dysfunction type 4.

Structure

The granulocyte-macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.^[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.^[3]

Signal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.^[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.^[4]

References

Further reading

• {{cite journal | vauthors = Rappold G, Willson TA, Henke A, Gough NM | title = Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region | journal = Genomics | volume = 14 | issue = 2 | pages = 455–61 | date = Oct 1992 | pmid = 1358805 | doi = 10.1016/S0888-7543(05)80241-1 }}
• {{cite journal | vauthors = Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A | title = Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 24 | pages = 9655–9 | date = Dec 1990 | pmid = 1702217 | pmc = 55231 | doi = 10.1073/pnas.87.24.9655 }}
• {{cite journal | vauthors = Crosier KE, Wong GG, Mathey-Prevot B, Nathan DG, Sieff CA | title = A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 17 | pages = 7744–8 | date = Sep 1991 | pmid = 1715577 | pmc = 52379 | doi = 10.1073/pnas.88.17.7744 }}
• {{cite journal | vauthors = Raines MA, Liu L, Quan SG, Joe V, DiPersio JF, Golde DW | title = Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 18 | pages = 8203–7 | date = Sep 1991 | pmid = 1832774 | pmc = 52475 | doi = 10.1073/pnas.88.18.8203 }}
• {{cite journal | vauthors = Gough NM, Gearing DP, Nicola NA, Baker E, Pritchard M, Callen DF, Sutherland GR | title = Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region | journal = Nature | volume = 345 | issue = 6277 | pages = 734–6 | date = Jun 1990 | pmid = 1972780 | doi = 10.1038/345734a0 }}
• {{cite journal | vauthors = Ashworth A, Kraft A | title = Cloning of a potentially soluble receptor for human GM-CSF | journal = Nucleic Acids Research | volume = 18 | issue = 23 | pages = 7178 | date = Dec 1990 | pmid = 2148207 | pmc = 332824 | doi = 10.1093/nar/18.23.7178 }}
• {{cite journal | vauthors = Gearing DP, King JA, Gough NM, Nicola NA | title = Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor | journal = The EMBO Journal | volume = 8 | issue = 12 | pages = 3667–76 | date = Dec 1989 | pmid = 2555171 | pmc = 402049 | doi = }}
• {{cite journal | vauthors = DiPersio J, Billing P, Kaufman S, Eghtesady P, Williams RE, Gasson JC | title = Characterization of the human granulocyte-macrophage colony-stimulating factor receptor | journal = The Journal of Biological Chemistry | volume = 263 | issue = 4 | pages = 1834–41 | date = Feb 1988 | pmid = 2828352 | doi = }}
• {{cite journal | vauthors = Williams WV, VonFeldt JM, Rosenbaum H, Ugen KE, Weiner DB | title = Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution | journal = Arthritis and Rheumatism | volume = 37 | issue = 10 | pages = 1468–78 | date = Oct 1994 | pmid = 7945472 | doi = 10.1002/art.1780371010 }}
• {{cite journal | vauthors = Jubinsky PT, Laurie AS, Nathan DG, Yetz-Aldepe J, Sieff CA | title = Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit | journal = Blood | volume = 84 | issue = 12 | pages = 4174–85 | date = Dec 1994 | pmid = 7994031 | doi = }}
• {{cite journal | vauthors = Hu X, Emanuel PD, Zuckerman KS | title = Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor | journal = Biochimica et Biophysica Acta | volume = 1223 | issue = 2 | pages = 306–8 | date = Sep 1994 | pmid = 8086503 | doi = 10.1016/0167-4889(94)90241-0 }}
• {{cite journal | vauthors = Nakagawa Y, Kosugi H, Miyajima A, Arai K, Yokota T | title = Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily | journal = The Journal of Biological Chemistry | volume = 269 | issue = 14 | pages = 10905–12 | date = Apr 1994 | pmid = 8144676 | doi = }}
• {{cite journal | vauthors = Zhao Y, Rong H, Chegini N | title = Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue | journal = Biology of Reproduction | volume = 53 | issue = 4 | pages = 923–30 | date = Oct 1995 | pmid = 8547489 | doi = 10.1095/biolreprod53.4.923 }}
• {{cite journal | vauthors = Lia F, Rajotte D, Clark SC, Hoang T | title = A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex | journal = The Journal of Biological Chemistry | volume = 271 | issue = 45 | pages = 28287–93 | date = Nov 1996 | pmid = 8910448 | doi = 10.1074/jbc.271.45.28287 }}
• {{cite journal | vauthors = Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY | title = Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor | journal = Journal of Immunology | volume = 157 | issue = 11 | pages = 5155–62 | date = Dec 1996 | pmid = 8943427 | doi = }}
• {{cite journal | vauthors = Soldi R, Primo L, Brizzi MF, Sanavio F, Aglietta M, Polentarutti N, Pegoraro L, Mantovani A, Bussolino F | title = Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor | journal = Blood | volume = 89 | issue = 3 | pages = 863–72 | date = Feb 1997 | pmid = 9028317 | doi = }}
• {{cite journal | vauthors = Matsuguchi T, Zhao Y, Lilly MB, Kraft AS | title = The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 28 | pages = 17450–9 | date = Jul 1997 | pmid = 9211889 | doi = 10.1074/jbc.272.28.17450 }}
• {{cite journal | vauthors = Rivas CI, Vera JC, Delgado-López F, Heaney ML, Guaiquil VH, Zhang RH, Scher HI, Concha II, Nualart F, Cordon-Cardo C, Golde DW | title = Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer | journal = Blood | volume = 91 | issue = 3 | pages = 1037–43 | date = Feb 1998 | pmid = 9446667 | doi = }}
• {{cite journal | vauthors = Hu X, Zuckerman KS | title = Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein | journal = American Journal of Hematology | volume = 58 | issue = 2 | pages = 145–7 | date = Jun 1998 | pmid = 9625584 | doi = 10.1002/(SICI)1096-8652(199806)58:2<145::AID-AJH11>3.0.CO;2-A }}
• {{cite journal | vauthors = Taha RA, Leung DY, Ghaffar O, Boguniewicz M, Hamid Q | title = In vivo expression of cytokine receptor mRNA in atopic dermatitis | journal = The Journal of Allergy and Clinical Immunology | volume = 102 | issue = 2 | pages = 245–50 | date = Aug 1998 | pmid = 9723668 | doi = 10.1016/S0091-6749(98)70093-4 }}

External links

• {{MeshName|GM-CSF+Receptor}}

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