“Granulopoiesis”的意思、由来-开放百科全书

Granulopoiesis (or granulocytopoiesis) is production of granulocytes. A granulocyte is a type of white blood cell that has multilobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell.^[1] This hematopoiesis occurs primarily within bone marrow.

Note that granulopoeisis does not generally include in the definition the generation of mast cells, since although they are granulocytes too, their maturation is extramedullar^[2].

The four key transcription factors involved in this process are C/EBPα, PU.1, CBF, and c-Myb.^[3]

References

1. ^{{cite web|last1=Monie|first1=Tom|title=The Innate Immune System: A compositional and functional perspective|url=https://www.sciencedirect.com/science/article/pii/B9780128044643010012|website=Science Direct|publisher=Christ’s College and Institute of Continuing Education, University of Cambridge, United Kingdom|accessdate=26 April 2018}}
2. ^{{cite book |last1=Mahler |first1=edited by Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, associate editor, Brad Bolon, Ricardo Ochoa, illustrations editor, Beth W. |title=Haschek and Rousseaux's handbook of toxicologic pathology |date=2013 |publisher=Academic Press |location=[S.l.] |isbn=978-0-12-415759-0 |page=1863 |edition=Third edition.}}
3. ^{{cite web|last1=Ward|first1=AC|last2=Loeb|first2=DM|last3=Soede-Bobok|first3=AA|last4=Touw|first4=IP|last5=Friedman|first5=AD|title=Regulation of granulopoiesis by transcription factors and cytokine signals|url=https://www.nature.com/articles/2401808|website=nature.com|publisher=Nature|accessdate=26 April 2018}}
4. ^{{cite journal |vauthors=Basu S, Zhang HH, Quilici C, Dunn AR |title=Candida albicans can stimulate stromal cells resulting in enhanced granulopoiesis |journal=Stem Cells Dev. |volume=13 |issue=1 |pages=39–50 |date=February 2004 |pmid=15068692 |doi=10.1089/154732804773099245}}