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词条 GRB10
释义

  1. Function

  2. Animal studies

  3. Interactions

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.[1][2][3][4]

Function

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

Animal studies

Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.[5]

Interactions

GRB10 has been shown to interact with

  • Abl gene,[7][8]
  • BCR gene,[6]
  • C-Raf,[7][8]
  • c-Kit,[9]
  • Insulin receptor,[10][11][12][13][17]
  • Insulin-like growth factor 1 receptor,[14][15][16][17]
  • MAP2K1,[8] and
  • RET proto-oncogene.[18]

References

1. ^1 {{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = }}
2. ^{{cite journal |vauthors=Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B | title = Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12 | journal = Genomics | volume = 40 | issue = 1 | pages = 215–6 |date=February 1997 | pmid = 9070953 | doi = 10.1006/geno.1996.4535 | url = | issn = }}
3. ^{{cite journal |vauthors=Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J | title = Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma | journal = J. Biol. Chem. | volume = 272 | issue = 46 | pages = 29104–12 |date=November 1997 | pmid = 9360986 | doi = 10.1074/jbc.272.46.29104| url = | issn = }}
4. ^{{cite journal |vauthors=Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE | title = Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression | journal = Hum. Mol. Genet. | volume = 18 | issue = 16 | pages = 3066–74 |date=August 2009 | pmid = 19487367 | doi = 10.1093/hmg/ddp248 | url = | issn = }}
5. ^{{cite journal |vauthors=Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A | title = Distinct physiological and behavioural functions for parental alleles of imprinted Grb10 | journal = Nature | year = 2011 | volume = 469 | pages = 534–538 | doi = 10.1038/nature09651 | laysummary = https://www.nytimes.com/2011/02/01/science/01obgene.html?partner=rss&emc=rss | laysource = New York Times | pmid=21270893 | issue = 7331 | pmc = 3031026 | bibcode=2011Natur.469..534G}}
6. ^1 {{cite journal |last=Bai |first=R Y |authorlink= |author2=Jahn T |author3=Schrem S |author4=Munzert G |author5=Weidner K M |author6=Wang J Y |author7=Duyster J |date=Aug 1998 |title=The SH2-containing adapter protein GRB10 interacts with BCR-ABL |journal=Oncogene |volume=17 |issue=8 |pages=941–8 |publisher= | issn = 0950-9232| pmid = 9747873 |doi = 10.1038/sj.onc.1202024 }}
7. ^{{cite journal |last=Nantel |first=A |authorlink= |author2=Huber M |author3=Thomas D Y |date=Dec 1999 |title=Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool |journal=J. Biol. Chem. |volume=274 |issue=50 |pages=35719–24 |publisher= | issn = 0021-9258| pmid = 10585452 |doi=10.1074/jbc.274.50.35719 }}
8. ^1 {{cite journal |last=Nantel |first=A |authorlink= |author2=Mohammad-Ali K |author3=Sherk J |author4=Posner B I |author5=Thomas D Y |date=Apr 1998 |title=Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases |journal=J. Biol. Chem. |volume=273 |issue=17 |pages=10475–84 |publisher= | issn = 0021-9258| pmid = 9553107 |doi=10.1074/jbc.273.17.10475 }}
9. ^{{cite journal |last=Jahn |first=Thomas |authorlink= |author2=Seipel Petra |author3=Urschel Susanne |author4=Peschel Christian |author5=Duyster Justus |date=Feb 2002 |title=Role for the adaptor protein Grb10 in the activation of Akt |journal=Mol. Cell. Biol. |volume=22 |issue=4 |pages=979–91 |publisher= | issn = 0270-7306| pmid = 11809791 |doi=10.1128/MCB.22.4.979-991.2002 |pmc=134632 }}
10. ^1 {{cite journal |last=Frantz |first=J D |authorlink= |author2=Giorgetti-Peraldi S |author3=Ottinger E A |author4=Shoelson S E |date=Jan 1997 |title=Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains |journal=J. Biol. Chem. |volume=272 |issue=5 |pages=2659–67 |publisher= | issn = 0021-9258| pmid = 9006901 |doi=10.1074/jbc.272.5.2659 }}
11. ^{{cite journal |last=Langlais |first=P |authorlink= |author2=Dong L Q |author3=Hu D |author4=Liu F |date=Jun 2000 |title=Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family |journal=Oncogene |volume=19 |issue=25 |pages=2895–903 |publisher= | issn = 0950-9232| pmid = 10871840 |doi = 10.1038/sj.onc.1203616 }}
12. ^{{cite journal |last=Hansen |first=H |authorlink= |author2=Svensson U |author3=Zhu J |author4=Laviola L |author5=Giorgino F |author6=Wolf G |author7=Smith R J |author8=Riedel H |date=Apr 1996 |title=Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus |journal=J. Biol. Chem. |volume=271 |issue=15 |pages=8882–6 |publisher= | issn = 0021-9258| pmid = 8621530 |doi=10.1074/jbc.271.15.8882 }}
13. ^{{cite journal |last=Liu |first=F |authorlink= |author2=Roth R A |date=Oct 1995 |title=Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue=22 |pages=10287–91 |publisher= | issn = 0027-8424| pmid = 7479769 |doi=10.1073/pnas.92.22.10287 |pmc=40781 |bibcode=1995PNAS...9210287L}}
14. ^1 {{cite journal |last=He |first=W |authorlink= |author2=Rose D W |author3=Olefsky J M |author4=Gustafson T A |date=Mar 1998 |title=Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains |journal=J. Biol. Chem. |volume=273 |issue=12 |pages=6860–7 |publisher= | issn = 0021-9258| pmid = 9506989 |doi=10.1074/jbc.273.12.6860}}
15. ^{{cite journal |last=Vecchione |first=Andrea |authorlink= |author2=Marchese Adriano |author3=Henry Pauline |author4=Rotin Daniela |author5=Morrione Andrea |date=May 2003 |title=The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor |journal=Mol. Cell. Biol. |volume=23 |issue=9 |pages=3363–72 |publisher= | issn = 0270-7306| pmid = 12697834 |doi=10.1128/MCB.23.9.3363-3372.2003 |pmc=153198 }}
16. ^{{cite journal |last=Dey |first=B R |authorlink= |author2=Frick K |author3=Lopaczynski W |author4=Nissley S P |author5=Furlanetto R W |date=Jun 1996 |title=Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10 |journal=Mol. Endocrinol. |volume=10 |issue=6 |pages=631–41 |publisher= | issn = 0888-8809| pmid = 8776723 |doi=10.1210/mend.10.6.8776723 }}
17. ^{{cite journal |last=Morrione |first=A |authorlink= |author2=Valentinis B |author3=Li S |author4=Ooi J Y |author5=Margolis B |author6=Baserga R |date=Jul 1996 |title=Grb10: A new substrate of the insulin-like growth factor I receptor |journal=Cancer Res. |volume=56 |issue=14 |pages=3165–7 |publisher= | issn = 0008-5472| pmid = 8764099 }}
18. ^{{cite journal |last=Pandey |first=A |authorlink= |author2=Duan H |author3=Di Fiore P P |author4=Dixit V M |date=Sep 1995 |title=The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 |journal=J. Biol. Chem. |volume=270 |issue=37 |pages=21461–3 |publisher= | issn = 0021-9258| pmid = 7665556 |doi=10.1074/jbc.270.37.21461 }}

Further reading

{{refbegin |33em}}
  • {{cite journal |vauthors=Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H |title=Severe Silver-Russell syndrome and translocation (17;20) (q25;q13) |journal=Clin. Genet. |volume=41 |issue= 1 |pages= 51–3 |year= 1992 |pmid= 1633648 |doi=10.1111/j.1399-0004.1992.tb03630.x }}
  • {{cite journal |vauthors=Liu F, Roth RA |title=Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10287–91 |year= 1995 |pmid= 7479769 |doi=10.1073/pnas.92.22.10287 | pmc=40781 |bibcode=1995PNAS...9210287L}}
  • {{cite journal |vauthors=Pandey A, Duan H, Di Fiore PP, Dixit VM |title=The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21461–3 |year= 1995 |pmid= 7665556 |doi=10.1074/jbc.270.37.21461 }}
  • {{cite journal |vauthors=Midro AT, Debek K, Sawicka A, etal |title=Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25 |journal=Clin. Genet. |volume=44 |issue= 1 |pages= 53–5 |year= 1993 |pmid= 8403458 |doi=10.1111/j.1399-0004.1993.tb03845.x }}
  • {{cite journal |vauthors=Hansen H, Svensson U, Zhu J, etal |title=Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8882–6 |year= 1996 |pmid= 8621530 |doi=10.1074/jbc.271.15.8882 }}
  • {{cite journal |vauthors=Morrione A, Valentinis B, Li S, etal |title=Grb10: A new substrate of the insulin-like growth factor I receptor |journal=Cancer Res. |volume=56 |issue= 14 |pages= 3165–7 |year= 1996 |pmid= 8764099 |doi= }}
  • {{cite journal |vauthors=O'Neill TJ, Rose DW, Pillay TS, etal |title=Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22506–13 |year= 1996 |pmid= 8798417 |doi=10.1074/jbc.271.37.22506 }}
  • {{cite journal |vauthors=Stein E, Cerretti DP, Daniel TO |title=Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23588–93 |year= 1996 |pmid= 8798570 |doi=10.1074/jbc.271.38.23588 }}
  • {{cite journal |vauthors=Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE |title=Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2659–67 |year= 1997 |pmid= 9006901 |doi=10.1074/jbc.272.5.2659 }}
  • {{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 }}
  • {{cite journal |vauthors=He W, Rose DW, Olefsky JM, Gustafson TA |title=Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6860–7 |year= 1998 |pmid= 9506989 |doi=10.1074/jbc.273.12.6860 }}
  • {{cite journal |vauthors=Nantel A, Mohammad-Ali K, Sherk J, etal |title=Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10475–84 |year= 1998 |pmid= 9553107 |doi=10.1074/jbc.273.17.10475 }}
  • {{cite journal |vauthors=Moutoussamy S, Renaudie F, Lago F, etal |title=Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 15906–12 |year= 1998 |pmid= 9632636 |doi=10.1074/jbc.273.26.15906 }}
  • {{cite journal |vauthors=Bai RY, Jahn T, Schrem S, etal |title=The SH2-containing adapter protein GRB10 interacts with BCR-ABL |journal=Oncogene |volume=17 |issue= 8 |pages= 941–8 |year= 1998 |pmid= 9747873 |doi= 10.1038/sj.onc.1202024 }}
  • {{cite journal |vauthors=Mano H, Ohya K, Miyazato A, etal |title=Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase |journal=Genes Cells |volume=3 |issue= 7 |pages= 431–41 |year= 1998 |pmid= 9753425 |doi=10.1046/j.1365-2443.1998.00201.x }}
  • {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }}
  • {{cite journal |vauthors=Angrist M, Bolk S, Bentley K, etal |title=Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease |journal=Oncogene |volume=17 |issue= 23 |pages= 3065–70 |year= 1999 |pmid= 9881709 |doi= 10.1038/sj.onc.1202226 }}
  • {{cite journal |vauthors=Wang J, Dai H, Yousaf N, etal |title=Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6217–28 |year= 1999 |pmid= 10454568 |doi= 10.1128/MCB.19.9.6217| pmc=84567 }}
{{refend}}

External links

  • {{MeshName|GRB10+Protein}}
{{PDB Gallery|geneid=2887}}{{Adaptor proteins}}{{NLM content}}
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