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词条 GRB2
释义

  1. Function and expression

  2. Domains

  3. Interactions

  4. See also

  5. References

  6. Further reading

  7. External links

{{Use mdy dates|date=May 2011}}{{Infobox_gene}}Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.[1][2]

The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]

Function and expression

Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. It is thus not surprising that targeted gene disruption of Grb2 in mice is lethal at an early embryonic stage. Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap. Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.

Domains

The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference for pY-X-N-X, where X is generally a hydrophobic residue such as valine (see  ).

The N-terminal SH3 domain binds to proline-rich peptides and can bind to the Ras-guanine exchange factor SOS.

The C-terminal SH3 domain binds to peptides conforming to a P-X-I/L/V/-D/N-R-X-X-K-P motif that allows it to specifically bind to proteins such as Gab-1.[4]

Interactions

Grb2 has been shown to interact with:

{{div col|colwidth=20em}}
  • ADAM15,[5]
  • Abl gene,[6][7]
  • Arachidonate 5-lipoxygenase,[8][9]
  • B-cell linker,[10][11][12][13]
  • BCAR1,[14][14]
  • BCR gene,[16][17][15][16][17][18]
  • Beta-2 adrenergic receptor,[19]
  • C-Met,[20][21]
  • CBLB,[22][23][24]
  • CD117,[28][25][26]
  • CD22,[27][28]
  • CD28,[29][30]
  • CDKN1B,[31]
  • CRK,[32][33][34]
  • Cbl gene,[22][40][41][42][43][44][35][36][37][38][39][40][41]
  • Colony stimulating factor 1 receptor,[42]
  • DCTN1,[43]
  • DNM1,[44][45]
  • Dock180,[46][47]
  • Dystroglycan,[48]
  • EPH receptor A2,[49]
  • ETV6,[16]
  • Epidermal growth factor receptor,[2][62][63][64][50][51][52][53][54][55]
  • Erythropoietin receptor,[56][57]
  • FRS2,[58][59][60][61]
  • Fas ligand,[62][63]
  • GAB1,[64][80][65]
  • GAB2,[66][67][68]
  • Glycoprotein 130,[85]
  • Granulocyte colony-stimulating factor receptor,[69]
  • HER2/neu,[70][88][71]
  • HNRNPC,[72]
  • Huntingtin,[73]
  • INPP5D,[74]
  • IRS1,[93][94][75]
  • ITK,[76][77]
  • Janus kinase 1,[93][78]
  • Janus kinase 2,[79][80]
  • KHDRBS1,[81][64][82]
  • Linker of activated T cells,[83][84][85]
  • Lymphocyte cytosolic protein 2,[86][87][88][89][90]
  • MAP2,[91][92]
  • MAP3K1[93]
  • MAP4K1,[94][95][96][97]
  • MED28,[98]
  • MST1R,[99][100]
  • MUC1,[101]
  • Mitogen-activated protein kinase 9,[102][103]
  • NCKIPSD,[104][105]
  • NEU3,[106]
  • PDGFRB,[55][107][108]
  • PIK3R1,[109][110]
  • PLCG1,[111][112][113]
  • PRKAR1A,[52]
  • PTK2,[114][115][116][117][118]
  • PTPN11,[69][108][145][119][120][121][122][123][124]
  • PTPN12,[125]
  • PTPN1,[126][127]
  • PTPN6,[42][119][128]
  • PTPRA,[129][130][131]
  • RAPGEF1,[132][133]
  • RET proto-oncogene,[134][135]
  • SH2B1,[136][137]
  • SH3KBP1,[138][139]
  • SHC1,[140][42][141][63][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158]
  • SOS1,[140][34][58][42][81][141][45][64][63][54][88][101][112][150][157][205][159][160][161][162][163]
  • Src,[164][165]
  • Syk,[164][119]
  • TNK2,[144][166]
  • TrkA,[167][168]
  • VAV1,[169][170][171][172]
  • VAV2,[173][174]
  • VAV3,[173][175] and
  • Wiskott-Aldrich syndrome protein.[176][177]
{{Div col end}}

See also

  • MAPK/ERK pathway

References

1. ^{{cite journal | vauthors = Matuoka K, Shibata M, Yamakawa A, Takenawa T | title = Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 19 | pages = 9015–9 | date = Oct 1992 | pmid = 1384039 | pmc = 50055 | doi = 10.1073/pnas.89.19.9015 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=1384039 }}
2. ^{{cite journal | vauthors = Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J | title = The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling | journal = Cell | volume = 70 | issue = 3 | pages = 431–42 | date = Aug 1992 | pmid = 1322798 | doi = 10.1016/0092-8674(92)90167-B | url = http://linkinghub.elsevier.com/retrieve/pii/0092-8674(92)90167-B }}
3. ^{{cite web | title = Entrez Gene: GRB2 growth factor receptor-bound protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2885| accessdate = }}
4. ^{{cite journal | vauthors = Berry DM, Nash P, Liu SK, Pawson T, McGlade CJ | title = A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling | journal = Current Biology | volume = 12 | issue = 15 | pages = 1336–41 | date = Aug 2002 | pmid = 12176364 | doi = 10.1016/S0960-9822(02)01038-2 }}
5. ^{{cite journal | vauthors = Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR | title = Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 4999–5007 | date = Feb 2002 | pmid = 11741929 | doi = 10.1074/jbc.M107430200 }}
6. ^{{cite journal | vauthors = Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M | title = The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33260–70 | date = Dec 1997 | pmid = 9407116 | doi = 10.1074/jbc.272.52.33260 }}
7. ^{{cite journal | vauthors = Ren R, Ye ZS, Baltimore D | title = Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites | journal = Genes & Development | volume = 8 | issue = 7 | pages = 783–95 | date = Apr 1994 | pmid = 7926767 | doi = 10.1101/gad.8.7.783 }}
8. ^{{cite journal | vauthors = VanderNoot VA, Fitzpatrick FA | title = Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2 | journal = Analytical Biochemistry | volume = 230 | issue = 1 | pages = 108–14 | date = Sep 1995 | pmid = 8585605 | doi = 10.1006/abio.1995.1444 }}
9. ^{{cite journal | vauthors = Lepley RA, Fitzpatrick FA | title = 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins | journal = The Journal of Biological Chemistry | volume = 269 | issue = 39 | pages = 24163–8 | date = Sep 1994 | pmid = 7929073 | doi = }}
10. ^{{cite journal | vauthors = Fu C, Turck CW, Kurosaki T, Chan AC | title = BLNK: a central linker protein in B cell activation | journal = Immunity | volume = 9 | issue = 1 | pages = 93–103 | date = Jul 1998 | pmid = 9697839 | doi = 10.1016/S1074-7613(00)80591-9}}
11. ^{{cite journal | vauthors = Engels N, Wollscheid B, Wienands J | title = Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha | journal = European Journal of Immunology | volume = 31 | issue = 7 | pages = 2126–34 | date = Jul 2001 | pmid = 11449366 | doi = 10.1002/1521-4141(200107)31:7<2126::aid-immu2126>3.0.co;2-o }}
12. ^{{cite journal | vauthors = Fusaki N, Tomita S, Wu Y, Okamoto N, Goitsuka R, Kitamura D, Hozumi N | title = BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking | journal = European Journal of Immunology | volume = 30 | issue = 5 | pages = 1326–30 | date = May 2000 | pmid = 10820378 | doi = 10.1002/(sici)1521-4141(200005)30:5<1326::aid-immu1326>3.0.co;2-q }}
13. ^{{cite journal | vauthors = Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M | title = SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation | journal = The Journal of Experimental Medicine | volume = 188 | issue = 4 | pages = 791–5 | date = Aug 1998 | pmid = 9705962 | pmc = 2213353 | doi = 10.1084/jem.188.4.791 }}
14. ^{{cite journal | vauthors = Wang X, Weng LP, Yu Q | title = Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR | journal = Oncogene | volume = 19 | issue = 19 | pages = 2346–53 | date = May 2000 | pmid = 10822386 | doi = 10.1038/sj.onc.1203558 }}
15. ^{{cite journal | vauthors = Million RP, Van Etten RA | title = The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase | journal = Blood | volume = 96 | issue = 2 | pages = 664–70 | date = Jul 2000 | pmid = 10887132 | doi = }}
16. ^{{cite journal | vauthors = Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J | title = The SH2-containing adapter protein GRB10 interacts with BCR-ABL | journal = Oncogene | volume = 17 | issue = 8 | pages = 941–8 | date = Aug 1998 | pmid = 9747873 | doi = 10.1038/sj.onc.1202024 }}
17. ^{{cite journal | vauthors = Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB | title = Bcr phosphorylated on tyrosine 177 binds Grb2 | journal = Oncogene | volume = 14 | issue = 19 | pages = 2367–72 | date = May 1997 | pmid = 9178913 | doi = 10.1038/sj.onc.1201053 }}
18. ^{{cite journal | vauthors = Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE | title = Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS | journal = Molecular and Cellular Biology | volume = 15 | issue = 2 | pages = 835–42 | date = Feb 1995 | pmid = 7529874 | pmc = 231961 | doi = }}
19. ^{{cite journal | vauthors = Karoor V, Wang L, Wang HY, Malbon CC | title = Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 33035–41 | date = Dec 1998 | pmid = 9830057 | doi = 10.1074/jbc.273.49.33035 }}
20. ^{{cite journal | vauthors = Ponzetto C, Zhen Z, Audero E, Maina F, Bardelli A, Basile ML, Giordano S, Narsimhan R, Comoglio P | title = Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility | journal = The Journal of Biological Chemistry | volume = 271 | issue = 24 | pages = 14119–23 | date = Jun 1996 | pmid = 8662889 | doi = 10.1074/jbc.271.24.14119 }}
21. ^{{cite journal | vauthors = Liang Q, Mohan RR, Chen L, Wilson SE | title = Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways | journal = Investigative Ophthalmology & Visual Science | volume = 39 | issue = 8 | pages = 1329–38 | date = Jul 1998 | pmid = 9660480 | doi = }}
22. ^{{cite journal | vauthors = Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S | title = cbl-b inhibits epidermal growth factor receptor signaling | journal = Oncogene | volume = 18 | issue = 10 | pages = 1855–66 | date = Mar 1999 | pmid = 10086340 | doi = 10.1038/sj.onc.1202499 }}
23. ^{{cite journal | vauthors = Lavagna-Sévenier C, Marchetto S, Birnbaum D, Rosnet O | title = The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 24 | pages = 14962–7 | date = Jun 1998 | pmid = 9614102 | doi = 10.1074/jbc.273.24.14962 }}
24. ^{{cite journal | vauthors = Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC | title = Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation | journal = Oncogene | volume = 18 | issue = 5 | pages = 1147–56 | date = Feb 1999 | pmid = 10022120 | doi = 10.1038/sj.onc.1202411 }}
25. ^{{cite journal | vauthors = De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R | title = Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation | journal = The EMBO Journal | volume = 18 | issue = 4 | pages = 904–15 | date = Feb 1999 | pmid = 10022833 | pmc = 1171183 | doi = 10.1093/emboj/18.4.904 }}
26. ^{{cite journal | vauthors = Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L | title = Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor | journal = The Biochemical Journal | volume = 341 | issue = 1| pages = 211–6 | date = Jul 1999 | pmid = 10377264 | pmc = 1220349 | doi = 10.1042/0264-6021:3410211}}
27. ^{{cite journal | vauthors = Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF | title = CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux | journal = The Journal of Biological Chemistry | volume = 275 | issue = 23 | pages = 17420–7 | date = Jun 2000 | pmid = 10748054 | doi = 10.1074/jbc.M001892200 }}
28. ^{{cite journal | vauthors = Otipoby KL, Draves KE, Clark EA | title = CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 44315–22 | date = Nov 2001 | pmid = 11551923 | doi = 10.1074/jbc.M105446200 }}
29. ^{{cite journal | vauthors = Okkenhaug K, Rottapel R | title = Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction | journal = The Journal of Biological Chemistry | volume = 273 | issue = 33 | pages = 21194–202 | date = Aug 1998 | pmid = 9694876 | doi = 10.1074/jbc.273.33.21194 }}
30. ^{{cite journal | vauthors = Nunès JA, Truneh A, Olive D, Cantrell DA | title = Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules | journal = The Journal of Biological Chemistry | volume = 271 | issue = 3 | pages = 1591–8 | date = Jan 1996 | pmid = 8576157 | doi = 10.1074/jbc.271.3.1591 }}
31. ^{{cite journal | vauthors = Sugiyama Y, Tomoda K, Tanaka T, Arata Y, Yoneda-Kato N, Kato J | title = Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12084–90 | date = Apr 2001 | pmid = 11278754 | doi = 10.1074/jbc.M010811200 }}
32. ^{{cite journal | vauthors = Riordan SM, Lidder S, Williams R, Skouteris GG | title = The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis | journal = The Biochemical Journal | volume = 350 | issue = 3| pages = 925–32 | date = Sep 2000 | pmid = 10970810 | pmc = 1221328 | doi = 10.1042/0264-6021:3500925 }}
33. ^{{cite journal | vauthors = Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T | title = Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins | journal = The Journal of Biological Chemistry | volume = 271 | issue = 24 | pages = 14468–72 | date = Jun 1996 | pmid = 8662907 | doi = 10.1074/jbc.271.24.14468 }}
34. ^{{cite journal | vauthors = Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25533–8 | date = Oct 1996 | pmid = 8810325 | doi = 10.1074/jbc.271.41.25533 }}
35. ^{{cite journal | vauthors = Jain SK, Langdon WY, Varticovski L | title = Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase | journal = Oncogene | volume = 14 | issue = 18 | pages = 2217–28 | date = May 1997 | pmid = 9174058 | doi = 10.1038/sj.onc.1201049 }}
36. ^{{cite journal | vauthors = Robertson H, Langdon WY, Thien CB, Bowtell DD | title = A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components | journal = Biochemical and Biophysical Research Communications | volume = 240 | issue = 1 | pages = 46–50 | date = Nov 1997 | pmid = 9367879 | doi = 10.1006/bbrc.1997.7608 }}
37. ^{{cite journal | vauthors = Donovan JA, Wange RL, Langdon WY, Samelson LE | title = The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor | journal = The Journal of Biological Chemistry | volume = 269 | issue = 37 | pages = 22921–4 | date = Sep 1994 | pmid = 8083187 | doi = }}
38. ^{{cite journal | vauthors = Gesbert F, Garbay C, Bertoglio J | title = Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 7 | pages = 3986–93 | date = Feb 1998 | pmid = 9461587 | doi = 10.1074/jbc.273.7.3986 }}
39. ^{{cite journal | vauthors = Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B | title = CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2 | journal = Oncogene | volume = 14 | issue = 19 | pages = 2331–8 | date = May 1997 | pmid = 9178909 | doi = 10.1038/sj.onc.1201074 }}
40. ^{{cite journal | vauthors = Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H | title = Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl | journal = Blood | volume = 89 | issue = 8 | pages = 2745–56 | date = Apr 1997 | pmid = 9108392 | doi = }}
41. ^{{cite journal | vauthors = Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J | title = Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates | journal = The EMBO Journal | volume = 27 | issue = 5 | pages = 804–16 | date = Mar 2008 | pmid = 18273061 | pmc = 2265755 | doi = 10.1038/emboj.2008.18 }}
42. ^{{cite journal | vauthors = Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T | title = Identification of a second Grb2 binding site in the v-Fms tyrosine kinase | journal = Oncogene | volume = 15 | issue = 13 | pages = 1565–72 | date = Sep 1997 | pmid = 9380408 | doi = 10.1038/sj.onc.1201518 }}
43. ^{{cite journal | vauthors = Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB | title = Identification of a novel 135-kDa Grb2-binding protein in osteoclasts | journal = The Journal of Biological Chemistry | volume = 271 | issue = 51 | pages = 33141–7 | date = Dec 1996 | pmid = 8955163 | doi = 10.1074/jbc.271.51.33141 }}
44. ^{{cite journal | vauthors = Miki H, Miura K, Matuoka K, Nakata T, Hirokawa N, Orita S, Kaibuchi K, Takai Y, Takenawa T | title = Association of Ash/Grb-2 with dynamin through the Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 269 | issue = 8 | pages = 5489–92 | date = Feb 1994 | pmid = 8119878 | doi = }}
45. ^{{cite journal | vauthors = Sastry L, Cao T, King CR | title = Multiple Grb2-protein complexes in human cancer cells | journal = International Journal of Cancer | volume = 70 | issue = 2 | pages = 208–13 | date = Jan 1997 | pmid = 9009162 | doi = 10.1002/(sici)1097-0215(19970117)70:2<208::aid-ijc12>3.0.co;2-e }}
46. ^{{cite journal | vauthors = Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD | title = Differential regulation of cell motility and invasion by FAK | journal = The Journal of Cell Biology | volume = 160 | issue = 5 | pages = 753–67 | date = Mar 2003 | pmid = 12615911 | pmc = 2173366 | doi = 10.1083/jcb.200212114 }}
47. ^{{cite journal | vauthors = Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M | title = DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane | journal = Molecular and Cellular Biology | volume = 16 | issue = 4 | pages = 1770–6 | date = Apr 1996 | pmid = 8657152 | pmc = 231163 | doi = }}
48. ^{{cite journal | vauthors = Yang B, Jung D, Motto D, Meyer J, Koretzky G, Campbell KP | title = SH3 domain-mediated interaction of dystroglycan and Grb2 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 20 | pages = 11711–4 | date = May 1995 | pmid = 7744812 | doi = 10.1074/jbc.270.20.11711 }}
49. ^{{cite journal | vauthors = Pratt RL, Kinch MS | title = Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade | journal = Oncogene | volume = 21 | issue = 50 | pages = 7690–9 | date = Oct 2002 | pmid = 12400011 | doi = 10.1038/sj.onc.1205758 }}
50. ^{{cite journal | vauthors = Wong L, Deb TB, Thompson SA, Wells A, Johnson GR | title = A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8900–9 | date = Mar 1999 | pmid = 10085134 | doi = 10.1074/jbc.274.13.8900 }}
51. ^{{cite journal | vauthors = Okutani T, Okabayashi Y, Kido Y, Sugimoto Y, Sakaguchi K, Matuoka K, Takenawa T, Kasuga M | title = Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells | journal = The Journal of Biological Chemistry | volume = 269 | issue = 49 | pages = 31310–4 | date = Dec 1994 | pmid = 7527043 | doi = }}
52. ^{{cite journal | vauthors = Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F | title = The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor | journal = Oncogene | volume = 14 | issue = 8 | pages = 923–8 | date = Feb 1997 | pmid = 9050991 | doi = 10.1038/sj.onc.1200906 }}
53. ^{{cite journal | vauthors = Daly RJ, Sanderson GM, Janes PW, Sutherland RL | title = Cloning and characterization of GRB14, a novel member of the GRB7 gene family | journal = The Journal of Biological Chemistry | volume = 271 | issue = 21 | pages = 12502–10 | date = May 1996 | pmid = 8647858 | doi = 10.1074/jbc.271.21.12502 }}
54. ^{{cite journal | vauthors = Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J | title = A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells | journal = The Journal of Biological Chemistry | volume = 269 | issue = 12 | pages = 9019–23 | date = Mar 1994 | pmid = 7510700 | doi = }}
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125. ^{{cite journal | vauthors = Charest A, Wagner J, Kwan M, Tremblay ML | title = Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2 | journal = Oncogene | volume = 14 | issue = 14 | pages = 1643–51 | date = Apr 1997 | pmid = 9135065 | doi = 10.1038/sj.onc.1201008 }}
126. ^{{cite journal | vauthors = Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M | title = Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 6 | pages = 4283–9 | date = Feb 2000 | pmid = 10660596 | doi = 10.1074/jbc.275.6.4283 }}
127. ^{{cite journal | vauthors = Liu F, Hill DE, Chernoff J | title = Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas) | journal = The Journal of Biological Chemistry | volume = 271 | issue = 49 | pages = 31290–5 | date = Dec 1996 | pmid = 8940134 | doi = 10.1074/jbc.271.49.31290 }}
128. ^{{cite journal | vauthors = Kon-Kozlowski M, Pani G, Pawson T, Siminovitch KA | title = The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 7 | pages = 3856–62 | date = Feb 1996 | pmid = 8632004 | doi = 10.1074/jbc.271.7.3856 }}
129. ^{{cite journal | vauthors = den Hertog J, Hunter T | title = Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains | journal = The EMBO Journal | volume = 15 | issue = 12 | pages = 3016–27 | date = Jun 1996 | pmid = 8670803 | pmc = 450243 | doi = }}
130. ^{{cite journal | vauthors = den Hertog J, Tracy S, Hunter T | title = Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo | journal = The EMBO Journal | volume = 13 | issue = 13 | pages = 3020–32 | date = Jul 1994 | pmid = 7518772 | pmc = 395191 | doi = }}
131. ^{{cite journal | vauthors = Zheng XM, Resnick RJ, Shalloway D | title = Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21922–9 | date = Jun 2002 | pmid = 11923305 | doi = 10.1074/jbc.M201394200 }}
132. ^{{cite journal | vauthors = Smit L, van der Horst G, Borst J | title = Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 15 | pages = 8564–9 | date = Apr 1996 | pmid = 8621483 | doi = 10.1074/jbc.271.15.8564 }}
133. ^{{cite journal | vauthors = Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K | title = C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 8 | pages = 3443–7 | date = Apr 1994 | pmid = 7512734 | pmc = 43593 | doi = 10.1073/pnas.91.8.3443 }}
134. ^{{cite journal | vauthors = Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA | title = The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins | journal = Oncogene | volume = 9 | issue = 6 | pages = 1661–8 | date = Jun 1994 | pmid = 8183561 | doi = }}
135. ^{{cite journal | vauthors = Pandey A, Duan H, Di Fiore PP, Dixit VM | title = The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 37 | pages = 21461–3 | date = Sep 1995 | pmid = 7665556 | doi = 10.1074/jbc.270.37.21461 }}
136. ^{{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = Nov 1998 | pmid = 9856458 | doi = 10.1016/s0896-6273(00)80620-0 }}
137. ^{{cite journal | vauthors = Kotani K, Wilden P, Pillay TS | title = SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase | journal = The Biochemical Journal | volume = 335 | issue = 1| pages = 103–9 | date = Oct 1998 | pmid = 9742218 | pmc = 1219757 | doi = 10.1042/bj3350103}}
138. ^{{cite journal | vauthors = Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL | title = Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 4015–25 | date = Aug 2000 | pmid = 10921882 | pmc = 306608 | doi = 10.1093/emboj/19.15.4015 }}
139. ^{{cite journal | vauthors = Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O | title = SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins | journal = Cellular Signalling | volume = 12 | issue = 11-12 | pages = 769–79 | date = Dec 2000 | pmid = 11152963 | doi = 10.1016/s0898-6568(00)00129-7 }}
140. ^{{cite journal | vauthors = Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T | title = Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway | journal = The EMBO Journal | volume = 13 | issue = 4 | pages = 764–73 | date = Feb 1994 | pmid = 8112292 | pmc = 394874 | doi = }}
141. ^{{cite journal | vauthors = Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL | title = High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase | journal = Journal of Immunology | volume = 163 | issue = 11 | pages = 6023–34 | date = Dec 1999 | pmid = 10570290 | doi = }}
142. ^{{cite journal | vauthors = Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF | title = The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling | journal = The EMBO Journal | volume = 12 | issue = 5 | pages = 1929–36 | date = May 1993 | pmid = 8491186 | pmc = 413414 | doi = }}
143. ^{{cite journal | vauthors = Zhang S, Mantel C, Broxmeyer HE | title = Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 372–80 | date = Mar 1999 | pmid = 10080542 | doi = }}
144. ^{{cite journal | vauthors = Satoh T, Kato J, Nishida K, Kaziro Y | title = Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation | journal = FEBS Letters | volume = 386 | issue = 2-3 | pages = 230–4 | date = May 1996 | pmid = 8647288 | doi = 10.1016/0014-5793(96)00449-8 }}
145. ^{{cite journal | vauthors = Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M | title = Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 13116–22 | date = May 1996 | pmid = 8662733 | doi = 10.1074/jbc.271.22.13116 }}
146. ^{{cite journal | vauthors = Ishihara H, Sasaoka T, Ishiki M, Takata Y, Imamura T, Usui I, Langlois WJ, Sawa T, Kobayashi M | title = Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors | journal = The Journal of Biological Chemistry | volume = 272 | issue = 14 | pages = 9581–6 | date = Apr 1997 | pmid = 9083103 | doi = 10.1074/jbc.272.14.9581 }}
147. ^{{cite journal | vauthors = Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP | title = Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling | journal = Oncogene | volume = 18 | issue = 2 | pages = 507–14 | date = Jan 1999 | pmid = 9927207 | doi = 10.1038/sj.onc.1202315 }}
148. ^{{cite journal | vauthors = Ravichandran KS, Burakoff SJ | title = The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation | journal = The Journal of Biological Chemistry | volume = 269 | issue = 3 | pages = 1599–602 | date = Jan 1994 | pmid = 8294403 | doi = }}
149. ^{{cite journal | vauthors = Lamprecht R, Farb CR, LeDoux JE | title = Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex | journal = Neuron | volume = 36 | issue = 4 | pages = 727–38 | date = Nov 2002 | pmid = 12441060 | doi = 10.1016/s0896-6273(02)01047-4 }}
150. ^{{cite journal | vauthors = Park RK, Izadi KD, Deo YM, Durden DL | title = Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling | journal = Blood | volume = 94 | issue = 6 | pages = 2112–20 | date = Sep 1999 | pmid = 10477741 | doi = }}
151. ^{{cite journal | vauthors = Sakaguchi K, Okabayashi Y, Kasuga M | title = Shc mediates ligand-induced internalization of epidermal growth factor receptors | journal = Biochemical and Biophysical Research Communications | volume = 282 | issue = 5 | pages = 1154–60 | date = Apr 2001 | pmid = 11302736 | doi = 10.1006/bbrc.2001.4680 }}
152. ^{{cite journal | vauthors = Hallak H, Seiler AE, Green JS, Henderson A, Ross BN, Rubin R | title = Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells | journal = Alcoholism: Clinical and Experimental Research | volume = 25 | issue = 7 | pages = 1058–64 | date = Jul 2001 | pmid = 11505033 | doi = 10.1111/j.1530-0277.2001.tb02317.x }}
153. ^{{cite journal | vauthors = Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin CH, Claesson-Welsh L | title = Direct interaction between Shc and the platelet-derived growth factor beta-receptor | journal = The Journal of Biological Chemistry | volume = 269 | issue = 21 | pages = 15337–43 | date = May 1994 | pmid = 8195171 | doi = }}
154. ^{{cite journal | vauthors = Lazar DF, Knez JJ, Medof ME, Cuatrecasas P, Saltiel AR | title = Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 21 | pages = 9665–9 | date = Oct 1994 | pmid = 7524086 | pmc = 44877 | doi = 10.1073/pnas.91.21.9665 }}
155. ^{{cite journal | vauthors = VanderKuur J, Allevato G, Billestrup N, Norstedt G, Carter-Su C | title = Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 13 | pages = 7587–93 | date = Mar 1995 | pmid = 7535773 | doi = 10.1074/jbc.270.13.7587 }}
156. ^{{cite journal | vauthors = Kanai M, Göke M, Tsunekawa S, Podolsky DK | title = Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6621–8 | date = Mar 1997 | pmid = 9045692 | doi = 10.1074/jbc.272.10.6621 }}
157. ^{{cite journal | vauthors = Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I | title = Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells | journal = The Journal of Biological Chemistry | volume = 269 | issue = 20 | pages = 14419–23 | date = May 1994 | pmid = 7514169 | doi = }}
158. ^{{cite journal | vauthors = Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G | title = Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase | journal = Journal of Immunology | volume = 158 | issue = 9 | pages = 4097–103 | date = May 1997 | pmid = 9126968 | doi = }}
159. ^{{cite journal | vauthors = Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J | title = Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | journal = Nature | volume = 363 | issue = 6424 | pages = 85–8 | date = May 1993 | pmid = 8479541 | doi = 10.1038/363085a0 }}
160. ^{{cite journal | vauthors = Reif K, Buday L, Downward J, Cantrell DA | title = SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 269 | issue = 19 | pages = 14081–7 | date = May 1994 | pmid = 8188688 | doi = }}
161. ^{{cite journal | vauthors = D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI | title = 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells | journal = Molecular Endocrinology | volume = 13 | issue = 5 | pages = 692–704 | date = May 1999 | pmid = 10319320 | doi = 10.1210/mend.13.5.0280 }}
162. ^{{cite journal | vauthors = Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS | title = The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain | journal = The EMBO Journal | volume = 19 | issue = 6 | pages = 1263–71 | date = Mar 2000 | pmid = 10716926 | pmc = 305667 | doi = 10.1093/emboj/19.6.1263 }}
163. ^{{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 412–7 | date = Oct 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}
164. ^{{cite journal | vauthors = Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C | title = Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement | journal = The Biochemical Journal | volume = 363 | issue = Pt 3 | pages = 717–25 | date = May 2002 | pmid = 11964172 | pmc = 1222524 | doi = 10.1042/0264-6021:3630717 }}
165. ^{{cite journal | vauthors = Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ | title = The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 18658–63 | date = May 2003 | pmid = 12624098 | doi = 10.1074/jbc.M212103200 }}
166. ^{{cite journal | vauthors = Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T | title = Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner | journal = Biochemical and Biophysical Research Communications | volume = 284 | issue = 2 | pages = 470–7 | date = Jun 2001 | pmid = 11394904 | doi = 10.1006/bbrc.2001.5004 }}
167. ^{{cite journal | vauthors = Song C, Perides G, Liu YF | title = Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6703–7 | date = Feb 2002 | pmid = 11733534 | doi = 10.1074/jbc.M110338200 }}
168. ^{{cite journal | vauthors = MacDonald JI, Gryz EA, Kubu CJ, Verdi JM, Meakin SO | title = Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18225–33 | date = Jun 2000 | pmid = 10748052 | doi = 10.1074/jbc.M001862200 }}
169. ^{{cite journal | vauthors = Lee IS, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T | title = Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6 | journal = FEBS Letters | volume = 401 | issue = 2-3 | pages = 133–7 | date = Jan 1997 | pmid = 9013873 | doi = 10.1016/s0014-5793(96)01456-1 }}
170. ^{{cite journal | vauthors = Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N | title = hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3798–807 | date = May 1999 | pmid = 10207103 | pmc = 84217 | doi = }}
171. ^{{cite journal | vauthors = Song JS, Gomez J, Stancato LF, Rivera J | title = Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex | journal = The Journal of Biological Chemistry | volume = 271 | issue = 43 | pages = 26962–70 | date = Oct 1996 | pmid = 8900182 | doi = 10.1074/jbc.271.43.26962 }}
172. ^{{cite journal | vauthors = Ye ZS, Baltimore D | title = Binding of Vav to Grb2 through dimerization of Src homology 3 domains | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 26 | pages = 12629–33 | date = Dec 1994 | pmid = 7809090 | pmc = 45492 | doi = 10.1073/pnas.91.26.12629 }}
173. ^{{cite journal | vauthors = Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M | title = A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling | journal = Nature Biotechnology | volume = 21 | issue = 3 | pages = 315–8 | date = Mar 2003 | pmid = 12577067 | doi = 10.1038/nbt790 }}
174. ^{{cite journal | vauthors = Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC | title = Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth | journal = The Journal of Biological Chemistry | volume = 276 | issue = 52 | pages = 48679–92 | date = Dec 2001 | pmid = 11606575 | doi = 10.1074/jbc.M106759200 }}
175. ^{{cite journal | vauthors = Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH | title = Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation | journal = Molecular and Cellular Biology | volume = 20 | issue = 24 | pages = 9212–24 | date = Dec 2000 | pmid = 11094073 | pmc = 102179 | doi = 10.1128/mcb.20.24.9212-9224.2000 }}
176. ^{{cite journal | vauthors = Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I | title = Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases | journal = Current Biology | volume = 6 | issue = 8 | pages = 981–8 | date = Aug 1996 | pmid = 8805332 | doi = 10.1016/s0960-9822(02)00642-5 }}
177. ^{{cite journal | vauthors = She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M, Margolis B, Li W | title = Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells | journal = Molecular Biology of the Cell | volume = 8 | issue = 9 | pages = 1709–21 | date = Sep 1997 | pmid = 9307968 | pmc = 305731 | doi = 10.1091/mbc.8.9.1709 }}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors = Colledge M, Froehner SC | title = Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction | journal = Annals of the New York Academy of Sciences | volume = 841 | issue = | pages = 17–27 | date = May 1998 | pmid = 9668219 | doi = 10.1111/j.1749-6632.1998.tb10907.x }}
  • {{cite journal | vauthors = Ramesh N, Antón IM, Martínez-Quiles N, Geha RS | title = Waltzing with WASP | journal = Trends in Cell Biology | volume = 9 | issue = 1 | pages = 15–9 | date = Jan 1999 | pmid = 10087612 | doi = 10.1016/S0962-8924(98)01411-1 }}
  • {{cite journal | vauthors = O'Sullivan E, Kinnon C, Brickell P | title = Wiskott-Aldrich syndrome protein, WASP | journal = The International Journal of Biochemistry & Cell Biology | volume = 31 | issue = 3-4 | pages = 383–7 | year = 1999 | pmid = 10224664 | doi = 10.1016/S1357-2725(98)00118-6 }}
  • {{cite journal | vauthors = Schlaepfer DD, Hauck CR, Sieg DJ | title = Signaling through focal adhesion kinase | journal = Progress in Biophysics and Molecular Biology | volume = 71 | issue = 3-4 | pages = 435–78 | year = 1999 | pmid = 10354709 | doi = 10.1016/S0079-6107(98)00052-2 }}
  • {{cite journal | vauthors = Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C | title = [Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2] | journal = Journal De La Société De Biologie | volume = 198 | issue = 2 | pages = 133–7 | year = 2004 | pmid = 15368963 | doi = }}
{{refend}}

External links

  • {{MeshName|GRB2+Adaptor+Protein}}
  • The Grb2 protein page on The SH2 Website
  • [https://www.genecards.org/cgi-bin/carddisp.pl?gene=GRB2&search=grb2 GeneCards entry for Grb2]
  • Human Protein Resource Database entry for Grb2
  • Grb2 information on iHOP (Information Hyperlinked over Proteins)
  • GRB2 Info with links in the Cell Migration Gateway
{{PDB Gallery|geneid=2885}}{{Adaptor proteins}}{{Cell signaling}}

3 : Proteins|Cell signaling|Signal transduction

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