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词条 Ground substance
释义

  1. See also

  2. References

  3. External links

Ground substance is an amorphous gel-like substance in the extracellular space that contains all components of the extracellular matrix (ECM) except for fibrous materials such as collagen and elastin.[1] Ground substance is active in the development, movement, and proliferation of tissues, as well as their metabolism. Additionally, cells use it for support, water storage, binding, and a medium for intercellular exchange (especially between blood cells and other types of cells). Ground substance provides lubrication for collagen fibers.[2]

The components of the ground substance vary depending on the tissue. Ground substance is primarily composed of water, glycosaminoglycans (GAGs) such as hyaluronic acid, heparan sulfate, dermatan sulfate, and chondroitin sulfate, proteoglycans which GAGs are bound to, and glycoproteins. Components of the ground substance are secreted by fibroblasts. Usually it is not visible on slides, because it is lost during staining in the preparation process.[3]

Link proteins such as vinculin, spectrin and actomyosin stabilize the proteoglycans and organize elastic fibers in the ECM.[2] Changes in the density of ground substance can allow collagen fibers to form aberrant cross-links.[2] Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense connective tissue has a smaller amount of ground substance compared to the fibrous material.[2]

The meaning of the term has evolved over time.[4]

See also

  • Milieu intérieur

References

1. ^{{cite web | first = Michelle | last = Peckham | name-list-format = vanc | title = Extracellular Matrix - 'Ground substance' | url = https://www.histology.leeds.ac.uk/tissue_types/connective/connective_groundS.php | publisher = University of Leeds }}
2. ^1 2 3 {{cite book |last1=Stecco |first1=Carla |last2=Hammer |first2=Warren |last3=Vleeming |first3=Andry |last4=De Caro |first4=Raffaele | name-list-format = vanc |chapter=Connective Tissues |title=Functional Atlas of the Human Fascial System |pages=1–20 |year=2015 | publisher = Churchill Livingstone Elsevier | doi = 10.1016/B978-0-7020-4430-4.00001-4 | isbn=978-0-7020-4430-4 }}
3. ^{{cite web|url=http://www.courseweb.uottawa.ca/medicine-histology/English/SS_BasicTissues/Connective_Tissue.htm | title=Connective Tissue | work = Self Study Unit of the Basic Tissues | publisher = University of Ottawa |access-date=2008-11-27 |deadurl=yes |archive-url=https://web.archive.org/web/20081107231710/http://www.courseweb.uottawa.ca/medicine-histology/English/SS_BasicTissues/Connective_Tissue.htm |archive-date=2008-11-07 }}
4. ^{{cite journal | vauthors = Wheatley DN | title = Diffusion, perfusion and the exclusion principles in the structural and functional organization of the living cell: reappraisal of the properties of the 'ground substance' | journal = The Journal of Experimental Biology | volume = 206 | issue = Pt 12 | pages = 1955–61 | date = June 2003 | pmid = 12756276 | doi = 10.1242/jeb.00238 }}

External links

  • {{cite book | first = Donald L. | last = Rubbelke | name-list-format = vanc | chapter = Connective Tissue Proper | title = Tissues of the Human Body: An Introduction. | chapter-url = http://www.mhhe.com/biosci/ap/histology_mh/ctprop.html | publisher = McGraw-Hill Companies | year = 1999 }}
{{Connective tissue}}{{biology-stub}}

2 : Biochemistry|Histology
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