| 词条 | Halazepam | ||||||||||||
| 释义 |
| Watchedfields = changed | verifiedrevid = 461743655 | IUPAC_name = 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one | image = Halazepam.svg | width = 170 | image2 = Halazepam3d.png | width2 = 150 | tradename = | Drugs.com = {{drugs.com|CONS|halazepam}} | MedlinePlus = a684001 | pregnancy_category = ? | legal_CA = Schedule IV | legal_DE = Rx-only/Anlage III | legal_US = Schedule IV | routes_of_administration = Oral | bioavailability = | metabolism = Hepatic | elimination_half-life = 14 hours (halazepam), 50–100 hours (metabolites). | excretion = Renal | IUPHAR_ligand = 7195 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 23092-17-3 | ATC_prefix = N05 | ATC_suffix = BA13 | PubChem = 31640 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00801 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 29343 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 320YC168LF | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00338 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 970 | C=17 | H=12 | Cl=1 | F=3 | N=2 | O=1 | molecular_weight = 352.7 g/mol | smiles = FC(F)(CN1C(CN=C(C2=CC=CC=C2)C3=C1C=CC(Cl)=C3)=O)F | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H12ClF3N2O/c18-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)22-9-15(24)23(14)10-17(19,20)21/h1-8H,9-10H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WYCLKVQLVUQKNZ-UHFFFAOYSA-N | synonyms = 9-chloro-6-phenyl-2-(2,2,2-trifluoroethyl)-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one }}Halazepam is a benzodiazepine derivative that was marketed under the brand names Paxipam in the United States,[1] Alapryl in Spain,[1] and Pacinone in Portugal.[2] Medical usesHalazepam was used for the treatment of anxiety.[1] Adverse effectsAdverse effects include drowsiness, confusion, dizziness, and sedation. Gastrointestinal side effects have also been reported including dry mouth and nausea.[1] Pharmacokinetics and pharmacodynamicsPharmacokinetics and pharmacodynamics were listed in Current Psychotherapeutic Drugs published in June 15, 1998 as follows:[3]
Regulatory InformationHalazepam is classified as a schedule 4 controlled substance with a corresponding code 2762 by the Drug Enforcement Administration (DEA).[4] Commercial productionHalazepam was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.[5] See also
References1. ^{{cite web|title=Alapryl|url=https://www.drugs.com/international/alapryl.html|publisher=Drugs.com|accessdate=December 11, 2014}} 2. ^{{cite web|title=Pacinone|url=https://www.drugs.com/international/pacinone.html|publisher=Drugs.com|accessdate=December 11, 2014}} 3. ^{{cite book|last1=Quitkin|first1=Frederick M. ... |title=Current therapeutic drugs|date=1998|publisher=American Psychiatric Press|location=Washington|isbn=0880489944|page=166|edition=2nd}} 4. ^{{cite web|title=SCHEDULES OF CONTROLLED SUBSTANCES|url=http://www.gpo.gov/fdsys/pkg/CFR-2012-title21-vol9/xml/CFR-2012-title21-vol9-part1308.xml|publisher=Code of Federal Reguations|accessdate=December 12, 2014|pages=§ 1308.14 Schedule IV|date=2012-04-01}} 5. ^1 2 3 {{cite web|title=halazepam|url=https://www.drugs.com/mtm/halazepam.html|publisher=Drugs.com|accessdate=December 11, 2014}} External links
6 : Abandoned drugs|Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Lactams|Trifluoromethyl compounds |
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