| 词条 | Haloxazolam |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | IUPAC_name = 10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one | image = Haloxazolam structure.svg | width = 150 | image2 = Haloxazolam3d.png | tradename = Somelin (JP) | Drugs.com = {{drugs.com|international|haloxazolam}} | pregnancy_category = | legal_CA = Schedule IV | legal_DE = Anlage III | legal_US = Schedule IV | routes_of_administration = Oral | bioavailability = | metabolism = Hepatic | elimination_half-life = | excretion = Renal | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 59128-97-1 | ATC_prefix = none | PubChem = 3563 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01476 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 3442 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2104461 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = M448L2V8XP verifiedrevid = 461766568 | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D01758 | C=17 | H=14 | Br=1 | F=1 | N=2 | O=2 | molecular_weight = 377.208 g/mol | smiles = Fc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Br)cc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XDKCGKQHVBOOHC-UHFFFAOYSA-N }}Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment insomnia.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[5] See also
References1. ^{{cite journal |pmid=8832439 |year=1996 |last1=Tanaka |first1=E |last2=Terada |last3=Misawa |last4=Wakasugi |title=Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel |volume=682 |issue=1 |pages=173–8 |journal=Journal of Chromatography B |doi=10.1016/0378-4347(96)00121-1 |first2=M |first3=S |first4=C }} {{Benzodiazepines}}{{Hypnotics and sedatives}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{cite web| url=http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html| title=Benzodiazepine Names| accessdate=2009-04-05| publisher=non-benzodiazepines.org.uk| deadurl=yes| archiveurl=https://web.archive.org/web/20081208054743/http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html| archivedate=2008-12-08| df=}} 3. ^{{cite journal |pmid=10022210 |year=1999 |last1=Guan |first1=F |last2=Seno |last3=Ishii |last4=Watanabe |last5=Kumazawa |last6=Hattori |last7=Suzuki |title=Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine |volume=23 |issue=1 |pages=54–61 |journal=Journal of Analytical Toxicology |first2=H |first3=A |first4=K |first5=T |first6=H |first7=O |doi=10.1093/jat/23.1.54}} 4. ^{{cite journal |pmid=12519461 |year=2003 |last1=Tan |first1=X |last2=Uchida |last3=Matsuura |last4=Nishihara |last5=Kojima |title=Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra |volume=57 |issue=1 |pages=97–104 |journal=Psychiatry and Clinical Neurosciences |doi=10.1046/j.1440-1819.2003.01085.x |first2=S |first3=M |first4=K |first5=T }} 5. ^{{cite journal |pmid=6139494 |year=1983 |last1=Sakai |first1=Y |title=Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems. |volume=33 |issue=5 |pages=1017–25 |journal=Japanese Journal of Pharmacology |doi=10.1254/jjp.33.1017 }} 5 : GABAA receptor positive allosteric modulators|Lactams|Organobromides|Fluoroarenes|Oxazolobenzodiazepines |
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