| 词条 | Hans Freeman |
| 释义 |
| name = Hans Freeman | birth_name = Hans Charles Freeman | honorific_suffix = AM, FAA | image = | image_size = | alt = | caption = | birth_date = {{birth date|df=yes|1929|05|26}} | birth_place = {{flagicon|GER}} Breslau, Germany (now Wrocław, Poland)[1] | death_date = {{Death date and age|df=yes|2008|11|09|1929|05|26}} | death_place = {{flagicon|AUS}} Sydney, Australia | body_discovered = | death_cause = | resting_place = | resting_place_coordinates = | monuments = | residence = | nationality = {{flagicon|AUS}} Australian | ethnicity = | citizenship = | other_names = | known_for = Protein crystallography | alma_mater = University of Sydney {{Plainlist|
| workplaces = University of Sydney (1954–2008) {{Plainlist|
| fields = Inorganic chemistry, Biochemistry | notable_students = Peter Colman[1] | boards = Director of K. H. Freeman Pty Ltd | spouse = Edith Freeman (née Siou), married 1966 | children = {{Plainlist|
| parents = Karl and Lotte Freeman | relations = Eva Freeman (sister) | awards = {{Plainlist|
| website = | footnotes = | box_width = }}Hans Charles Freeman AM, FAA (26 May 1929 – 9 November 2008) was a German-born Australian bioinorganic chemist, protein crystallographer, and Professor of Inorganic Chemistry who spent most of his academic career at the University of Sydney.[2] His best known contributions to chemistry were his work explaining the unusual structural, electrochemical, and spectroscopic properties of blue copper proteins, particularly plastocyanin.[4] He also introduced protein crystallography to Australia[5] and was a strong advocate for programs to ensure Australian scientists have good access to "big science" facilities.[6] Freeman has received numerous honours, including being elected a Fellow of the Australian Academy of Science (FAA)[7] and appointed a Member of the Order of Australia (AM)[8] by the Australian Government. He was a charismatic lecturer who voluntarily continued teaching well into his formal retirement and imbued his students with a love of science.[2] BiographyEarly years and educationHans Charles Freeman was the first and only son of Karl and Lotte Freeman and was born in Breslau in Germany in 1929[5] (now Wrocław, Poland).[3] In 1938, following a tip-off from a Nazi party member, Karl decided to relocate his Jewish family to Australia. Karl brought his knowledge of detergents (a novelty in Australia at the time) to his new homeland, applying it to the problem of cleaning blood-stained blankets that would otherwise be wasted.[6] After the war, he founded K. H. Freeman Pty Ltd, a detergent and soap manufacturing company; Hans spent many weekends working in the factory, gaining a practical insight into chemistry.[5] Hans adapted well to his new environment, quickly mastering his new language and demonstrating his outstanding scholastic ability. He was dux of his primary school, dux of Sydney Boys High in 1945,[4] and took his Bachelor's degree with the university medal in chemistry in 1949.[5] He was one of the ten chemistry students in his class at Sydney Boys High to go on to become Professors of Chemistry.[6] After receiving his MSc in 1952 under the supervision of Raymond Le Fèvre FRS, Freeman attended Caltech on a Rotary Foundation Fellowship where, at the urging of Linus Pauling, he learned the fundamentals of crystallography.[6] He received a PhD in 1957 for his work on the structure of biuret hydrate,[7][8] where he completed most of the calculations for the crystal structure by hand.[6] Personal lifeFreeman came to Australia with his parents and his sister, Eva. Following the death of his father in 1958, he became a Director of K. H. Freeman Pty Ltd, which continues to operate today. He met Edith Siou in 1964 and they married in 1966. They have two children, Maeva and Philip.[5] CareerFreeman was appointed to the faculty of the University of Sydney in 1954 as a Lecturer, working his way up until he was made the inaugural Professor of Inorganic Chemistry in 1971.[6] Freeman pioneered the use of computers in crystallography in Australia, working on SILLIAC (the Australian cousin of the University of Illinois' ILLIAC machine and Australia's second computer) after its installation in 1956. His research group extended its interests beyond purely organic compounds and on to metal complexes (such as copper biuret, one of the first bioinorganic substances to be structurally determined[6]) and went on to determine the structures of numerous metal complexes of amino acids and peptides.[10] In 1970, the focus of Freeman's research became protein crystallography and he turned his attention to the blue copper proteins (cupredoxins) and particularly the electron transport protein plastocyanin. The intensely blue colour of plastocyanin and its unusual redox properties had frustrated all attempts to synthesise a small molecule mimic.[10] It was not until 1977 that his group finally determined the structure of plastocyanin crystallised from the poplar tree[11][12] (see diagram at right); this was the first protein crystal structure determined in the southern hemisphere.[29] Together with subsequent work in collaboration with Ed Solomon,[13] this work led to understanding of the unusual geometry of the copper metal site (see diagram at left) as well as the spectroscopic and electrochemical properties characteristic of blue copper proteins.[6] Later in his career, Freeman developed an interest in the applications of EXAFS spectroscopy to metalloprotein structure, collaborating with both James Penner-Hahn[14][15] and Keith Hodgson.[6] Working together, the Freeman and Hodgson groups were, in 1988, the first to determine a new crystal structure of a protein using the multiple wavelength anomalous dispersion (MAD) method.[16] Throughout his career, Freeman was concerned about the influence of the tyranny of distance[17] on the development of Australian science. For this reason, in 1972 Freeman and Alexander Boden AO, FAA, founded the Foundation for Inorganic Chemistry at the university to bring international scholars to the department to deliver a course for graduate students and give seminars for faculty.[2] The inaugural Foundation scholar was nobel laureate Linus Pauling[18] and the Foundation has brought many other eminent research chemists to Australia. The Foundation has thus functioned to increase Australian awareness of state of the art international research, increased international recognition of Australian research, and allowed graduate students to interact with leading chemists based in institutions far from Australia.[6] Many of the students have gone on to post-graduate or post-doctoral positions with a Foundation scholar.[10] Freeman also provided advice to the Australian Government on the problem of access to "big science" facilities. This included making major contributions to the report Small Country - Big Science[19] in his work for the Australian Science and Technology Council.[6] The report emphasised the need for Australian researchers to have access to facilities such as synchrotron X-ray and high intensity neutron sources, and led directly to the formation of the Australian Synchrotron Research Programme (ASRP) to fund access to such facilities. Freeman served as a board member of the ASRP until its functions were subsumed under the newly commissioned Australian Synchrotron in 2008.[10] The Australian expertise developed as a consequence of ASRP-supported research led to the Australian Synchrotron being built a decade sooner than would have otherwise been the case.[6] Freeman retired from his Chair in 1997, and was succeeded by Len Lindoy FAA. Nevertheless, he continued working in research and became Emeritus Professor of Chemistry and Emeritus Professor of Molecular and Microbial Biosciences. He also voluntarily continued teaching at first-year level.[5] His lecturing was described as "charismatic" and "teaching was a love and a privilege and never an obligation" for him.[2] LegacyFreeman was principally responsible for the establishment of structural biology as a discipline in Australia.[8] He founded the first protein crystallography laboratory in Australia; today, there are more than 15 active research groups carrying out protein crystallography in Australia and New Zealand.[10] Many former members of the Freeman research group have moved on to join one of these other groups.[6] The groups interact through the Society of Crystallographers of Australia and New Zealand (SCANZ); Freeman was the Foundation President of then Society of Crystallographers of Australia, an organisation he was instrumental in forming in 1976.[2] Working as a crystallographer, Freeman's major legacies are the understanding of plastocyanin and other blue copper proteins, and development of the MAD method as an extension of EXAFS spectroscopy. Freeman's work in ensuring Australian scientists have access to "big science" facilities will continue to assist researchers into the future. His teaching also leaves a legacy of "generations of students imbued with a love of science".[2] Honours and awardsFreeman was recognised for his professional achievements with Fellowships in the Royal Australian Chemical Institute (RACI) in 1968, the Royal Society of Chemistry in 1984,[20] and the Australian Academy of Science in 1984.[21] Freeman's contributions were also recognised by the Australian Government with a Centenary Medal in 2001 for "service to Australian society and science in chemistry"[22] and with his appointment as a Member of the Order of Australia in June 2005 for "service to science and scientific research in the field of bio-inorganic chemistry, particularly through the establishment and development of the discipline of crystallography in Australia".[23] Freeman received numerous awards over his long career. In 1980, Freeman received the Burrows Award, the premier award of the Inorganic Chemistry Division of the RACI.[24] He was also awarded the 1999 Leighton Memorial Medal[25] which is "the RACI's most prestigious medal and is awarded in recognition of eminent services to chemistry in Australia in the broadest sense."[26] In 2007, he received both the Australian Academy of Science's Craig Medal[27] and an RACI Distinguished Fellowship.[28][29] Most cited publicationsThe number of citations indicated for each of the following papers are from Web of Science data as at 22 June 2013:
References1. ^1 {{Cite journal | doi = 10.1038/272319a0 | title = X-ray crystal structure analysis of plastocyanin at 2.7 Å resolution | journal = Nature | volume = 272 | issue = 5651 | pages = 319–324 | year = 1978 | last1 = Colman | first1 = P. M. | authorlink1 = Peter Colman | last2 = Freeman | first2 = H. C. | last3 = Guss | first3 = J. M. | last4 = Murata | first4 = M. | last5 = Norris | first5 = V. A. | last6 = Ramshaw | first6 = J. A. M. | last7 = Venkatappa | first7 = M. P. | bibcode = 1978Natur.272..319C}} {{Good article}}{{authority control}}{{DEFAULTSORT:Freeman, Hans Charles}}2. ^1 2 3 4 5 {{cite journal |title= Obituary: Hans C. Freeman (1929–2008)|first1= M.|last1= Guss|journal= International Union of Crystallography Newsletter|volume= 17|issue= 2|year= 2009|url= http://www.iucr.org/news/newsletter/volume-17/number-2/hans-c.-freeman}} 3. ^1 {{cite book|chapter = A Note on Names|pages = xi-xii|title = Uprooted: How Breslau Became Wroclaw during the Century of Expulsions|first = Gregor|last = Thum|authorlink = Gregor Thum|publisher = Princeton University Press|year = 2011|isbn = 9781400839964|url = https://books.google.com/books?id=D3IDT1RmI38C&pg=PR11|quote = [W]hen German Breslau was ceded to Poland [in 1945] ... the city name became a politically sensitive issue. ... This changed in 1990, however. With the definitive recognition of Poland's western border by a reunified Germany and the ensuing German-Polish reconciliation, Wroclaw's city name soon ceased to be a political issue. While people no longer question that "Wroclaw" is the only official name today, the use of "Breslau" within the German language is fully accepted.}} 4. ^http://www.shsobu.org.au/wp-content/uploads/professors.pdf 5. ^1 2 3 4 5 {{Cite news|last = Stephens|first = T.|title = From riches to rags to protein pioneer|newspaper = Sydney Morning Herald|location = Sydney|date = 5 December 2008|url = http://www.smh.com.au/news/obituaries/from-riches-to-rags-to-protein-pioneer/2008/12/04/1228257223616.html|accessdate = 30 July 2010}} 6. ^1 2 3 4 {{cite journal|year=2009|title=Hans Freeman 1929–2008|last1=Hambley|first1=T.|journal=J. Biol. Inorg. Chem.|volume=14|issue=3|pages=327–328|doi=10.1007/s00775-009-0484-x}} 7. ^{{cite journal|doi=10.1038/184707a0|year=1959|title=Crystallographic Studies of the Biuret Reaction|last1=Freeman|first1=H. C.|last2=Smith|first2=J. E. W. L.|last3=Taylor|first3=J. C.|journal=Nature|volume=184|issue=4687|pages=707–710|pmid=13824733|bibcode = 1959Natur.184..707F }} 8. ^{{cite journal|doi=10.1107/S0365110X61001194|year=1961|title=The Crystal Structure of Biuret Hydrate|last1=Hughes|first1=E. W.|last2=Yakel|first2=H. L.|last3=Freeman|first3=H. C.|journal=Acta Crystallogr.|volume=14|issue=4|pages=345–352}} 9. ^{{cite journal |last1= Guss|first1= J. M.|last2= Bartunik|first2= H. D.|last3= Freeman|first3= H. C.|title= Accuracy and Precision in Protein Structure Analysis: Restrained Least-Squares Refinement of the Structure of Poplar Plastocyanin at 1.33 Å Resolution|journal= Acta Crystallogr. B |volume= 48|issue= 6|pages= 790–811|year=1992 |doi= 10.1107/S0108768192004270 |pmid=1492962}} 10. ^1 2 3 4 {{cite journal|year=2009|title=Hans C. Freeman (1929–2009) Obituary|last1=Guss|first1=J. M.|journal=Acta Crystallogr. D|volume=65|issue=1|pages=93–95|doi=10.1107/S0907444908041565}} 11. ^{{cite journal|last1= Chapman|first1= G. V.|last2= Colman|first2= P. M.|authorlink2= Peter Colman|last3= Freeman|first3= H. C.|last4= Guss|first4= J. M.|last5= Murata|first5= M.|last6= Norris|first6= V. A.|last7= Ramshaw|first7= J. A. M.|last8= Venkatappa|first8= M. P.|title= Preliminary Crystallographic Data for a Copper-Containing Protein, Plastocyanin|journal= J. Mol. Biol.|volume= 110|issue= 1|pages= 187–189|year= 1977|doi= 10.1016/S0022-2836(77)80106-X|pmid= 845945}} 12. ^{{cite journal|last1= Colman|first1= P. M.|authorlink1= Peter Colman|last2= Freeman|first2= H. C.|last3= Guss|first3= J. M.|last4= Murata|first4= M.|last5= Norris|first5= V. A.|last6= Ramshaw|first6= J. A. M.|last7= Venkatappa|first7= M. P.|title= X-Ray Crystal Structure Analysis of Plastocyanin at 2.7 Å Resolution|journal= Nature |volume= 272|issue= 5651|pages= 319–324|year= 1978|doi= 10.1038/272319a0|bibcode = 1978Natur.272..319C }} 13. ^{{cite journal|last1= Penfield|first1= K. W.|last2= Gay|first2= R. R.|last3= Himmelwright|first3= R. S.|last4= Eickman|first4= N. C.|last5= Norris|first5= V. A.|last6= Freeman|first6= H. C.|last7= Solomon|first7= E. I.|authorlink7= Edward I. Solomon|title= Spectroscopic Studies on Plastocyanin Single-Crystals: A Detailed Electronic-Structure Determination of the Blue Copper Active-Site|journal= J. Am. Chem. Soc. |volume= 103|issue= 15|pages= 4382–4388|year= 1981|doi= 10.1021/ja00405a016}} 14. ^{{cite journal|last1= Scott|first1= R. A.|last2= Hahn|first2= J. E.|authorlink2= James Penner-Hahn|last3= Doniach|first3= S.|last4= Freeman|first4= H. C.|last5= Hodgson|first5= K. O.|authorlink5= Keith Hodgson|title= Polarized X-Ray Absorption Spectra of Oriented Plastocyanin Single Crystals. Investigation of Methionine-Copper Coordination|journal= J. Am. Chem. Soc.|volume= 104|issue= 20|pages= 5364–5369|year= 1982|doi= 10.1021/ja00384a020}} 15. ^{{cite journal|last1= Penner-Hahn|first1= J. E.|authorlink1= James Penner-Hahn|last2= Murata|first2= M.|last3= Hodgson|first3= K. O.|last4= Freeman|first4= H. C.|authorlink3= Keith Hodgson|title= Low-Temperature X-Ray Absorption Spectroscopy of Plastocyanin: Evidence for Copper-Site Photoreduction at Cryogenic Temperatures|journal= Inorg. Chem.|volume= 28|issue= 10|pages= 1826–1832|year= 1989|doi= 10.1021/ic00309a015}} 16. ^{{cite journal|last1= Guss|first1= J. M.|last2= Merritt|first2= E. A.|last3= Phizackerley|first3= R. P.|last4= Hedman|first4= B.|last5= Murata|first5= M.|last6= Hodgson|first6= K. O.|authorlink6= Keith Hodgson|last7= Freeman|first7= H. C.|title= Phase Determination by Multiple-Wavelength X-ray Diffraction: Crystal Structure of a Basic "Blue" Copper Protein from Cucumbers|journal= Science|volume= 241|issue= 4867|pages= 806–811|year= 1988|doi= 10.1126/science.3406739|pmid= 3406739|bibcode= 1988Sci...241..806G|jstor= 1702012}} {{subscription}} 17. ^The phrase "the tyranny of distance" comes from the 1966 book How Distance Shaped Australia's History by Geoffrey Blainey 18. ^{{cite web|url= http://www.science.org.au/fellows/memoirs/boden.html|title= Biographical Memoirs: Alexander Boden 1913–1993|work= science.org.au|accessdate= 8 August 2010|deadurl= yes|archiveurl= https://web.archive.org/web/20100502194648/http://www.science.org.au/fellows/memoirs/boden.html|archivedate= 2 May 2010|df= dmy-all}} 19. ^{{cite book |author= Australian Science and Technology Council|authorlink= Australian Science, Technology and Engineering Council|title= Small Country - Big Science: A Report to the Prime Minister on Australian Participation in Major International Accelerator and Beam Facilities |url= http://catalogue.nla.gov.au/Record/1831716|year= 1990|publisher= Australian Government Publishing Service|isbn= 0-644-11982-9}} 20. ^1 2 3 4 5 6 7 8 9 {{cite journal|year=1995|title=Hans C. Freeman|last1=Hambley|first1=T.|journal=Aust. J. Chem.|volume=48|issue=4|pages=697–699|doi=10.1071/CH9950697}} 21. ^1 {{cite web|url=http://www.science.org.au/fellows/deceased.html#f|title=Australian Academy of Science - Deceased Fellows and Memiors|work=science.org.au|accessdate= 6 August 2010}} 22. ^{{cite web|url=http://www.itsanhonour.gov.au/honours/honour_roll/search.cfm?aus_award_id=1127327&search_type=quick&showInd=true|title=FREEMAN, Hans Charles: Centenary Medal|work=itsanhonour.gov.au|accessdate= 30 July 2010}} 23. ^1 2 {{cite web|url=http://www.itsanhonour.gov.au/honours/honour_roll/search.cfm?aus_award_id=1135946&search_type=simple&showInd=true|title=FREEMAN, Hans Charles: Member of the Order of Australia|work=itsanhonour.gov.au|accessdate= 6 October 2010}} 24. ^{{cite web|url=http://www.raci.org.au/page/Divisions/Inorganic-Chemistry/Inorganic-Chemistry-Awards.htm|title=Inorganic Chemistry Awards|publisher=Royal Australian Chemical Institute|website=raci.org.au|accessdate= 30 July 2010|archiveurl=https://web.archive.org/web/20100804060334/http://www.raci.org.au/page/Divisions/Inorganic-Chemistry/Inorganic-Chemistry-Awards.htm |archivedate=4 August 2010}} 25. ^{{cite web|url=http://www.raci.org.au/page/Awards/Past-Award-Winners.htm#leighton|title=Past Award Winners - Leighton Memorial Medal|publisher=Royal Australian Chemical Institute|website=raci.org.au|accessdate= 30 July 2010|archiveurl=https://web.archive.org/web/20100715004607/http://www.raci.org.au/page/Awards/Past-Award-Winners.htm |archivedate=15 July 2010}} 26. ^{{cite web|url=http://www.raci.org.au/site/1/common/Leighton2009%20Medal.pdf|title=Leighton Medal|publisher=Royal Australian Chemical Institute|website=raci.org.au|accessdate=30 July 2010}}{{dead link|date=October 2017 |bot=InternetArchiveBot |fix-attempted=yes }} 27. ^1 {{cite web|url=http://www.science.org.au/awards/awardees/2007awards.html|title=2007 Awards|work=science.org.au|accessdate=30 July 2010|deadurl=yes|archiveurl=https://web.archive.org/web/20100427071057/http://www.science.org.au/awards/awardees/2007awards.html|archivedate=27 April 2010|df=dmy-all}} 28. ^{{cite web|url=http://www.raci.org.au/site/1/common/Distinguished2009%20Fellowship.pdf|title=Distinguished Fellowship|publisher=Royal Australian Chemical Institute|website=raci.org.au|accessdate=30 July 2010}}{{dead link|date=October 2017 |bot=InternetArchiveBot |fix-attempted=yes }} 29. ^{{cite web|url=http://www.raci.org.au/page/Awards/Past-Award-Winners.htm#distinguishedfellowship|title=Past Award Winners - Distinguished Fellowship|publisher=Royal Australian Chemical Institute|website=raci.org.au|accessdate= 30 July 2010|archiveurl=https://web.archive.org/web/20100715004607/http://www.raci.org.au/page/Awards/Past-Award-Winners.htm |archivedate=15 July 2010}} 13 : Australian chemists|German chemists|1929 births|People from Wrocław|2008 deaths|Fellows of the Australian Academy of Science|Members of the Order of Australia|Recipients of the Centenary Medal|University of Sydney alumni|University of Sydney faculty|People educated at Sydney Boys High School|20th-century chemists|20th-century German scientists |
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