| 释义 |
- Function
- Interactions
- References
- Further reading
{{For|the ice hockey team|HC Keski-Uusimaa}}{{Infobox_gene}}Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.[1] Function The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types, and belongs to the Src family of tyrosine kinases. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.[2] Interactions HCK has been shown to interact with: {{div col|colwidth=20em}}- ADAM15[3]
- BCR gene,[4][5]
- Cbl gene,[6][7]
- ELMO1,[8]
- Granulocyte colony-stimulating factor receptor,[9]
- RAPGEF1,[10]
- RAS p21 protein activator 1,[11] and
- RASA3.[11]
{{Div col end}} References 1. ^{{cite journal | vauthors = Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD | title = Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells | journal = Mol Cell Biol | volume = 7 | issue = 6 | pages = 2267–75 | date = August 1987 | pmid = 3496523 | pmc = 365351 | doi = }}
2. ^{{cite web | title = Entrez Gene: HCK hemopoietic cell kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3055| accessdate = }}
3. ^{{cite journal | vauthors = Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR | title = Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 4999–5007 | date = Feb 2002 | pmid = 11741929 | doi = 10.1074/jbc.M107430200 }}
4. ^{{cite journal | vauthors = Stanglmaier M, Warmuth M, Kleinlein I, Reis S, Hallek M | title = The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains | journal = Leukemia | volume = 17 | issue = 2 | pages = 283–9 | date = Feb 2003 | pmid = 12592324 | doi = 10.1038/sj.leu.2402778 }}
5. ^{{cite journal | vauthors = Lionberger JM, Wilson MB, Smithgall TE | title = Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18581–5 | date = Jun 2000 | pmid = 10849448 | doi = 10.1074/jbc.C000126200 }}
6. ^{{cite journal | vauthors = Howlett CJ, Robbins SM | title = Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation | journal = Oncogene | volume = 21 | issue = 11 | pages = 1707–16 | date = Mar 2002 | pmid = 11896602 | doi = 10.1038/sj.onc.1205228 }}
7. ^{{cite journal | vauthors = Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM | title = The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase | journal = Biochemical and Biophysical Research Communications | volume = 257 | issue = 1 | pages = 129–38 | date = Apr 1999 | pmid = 10092522 | doi = 10.1006/bbrc.1999.0427 }}
8. ^{{cite journal | vauthors = Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT | title = Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 28238–46 | date = Aug 2002 | pmid = 12029088 | doi = 10.1074/jbc.M202783200 }}
9. ^{{cite journal | vauthors = Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA | title = The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor | journal = Biochemical and Biophysical Research Communications | volume = 251 | issue = 1 | pages = 117–23 | date = Oct 1998 | pmid = 9790917 | doi = 10.1006/bbrc.1998.9441 }}
10. ^{{cite journal | vauthors = Shivakrupa R, Radha V, Sudhakar C, Swarup G | title = Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 52 | pages = 52188–94 | date = Dec 2003 | pmid = 14551197 | doi = 10.1074/jbc.M310656200 }}
11. ^1 {{cite journal | vauthors = Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE | title = The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck | journal = The Journal of Biological Chemistry | volume = 270 | issue = 24 | pages = 14718–24 | date = Jun 1995 | pmid = 7782336 | doi = 10.1074/jbc.270.24.14718}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Geyer M, Fackler OT, Peterlin BM | title = Structure--function relationships in HIV-1 Nef. | journal = EMBO Rep. | volume = 2 | issue = 7 | pages = 580–5 | year = 2001 | pmid = 11463741 | pmc = 1083955 | doi = 10.1093/embo-reports/kve141 }}
- {{cite journal | vauthors = Lake JA, Carr J, Feng F, Mundy L, Burrell C, Li P | title = The role of Vif during HIV-1 infection: interaction with novel host cellular factors. | journal = J. Clin. Virol. | volume = 26 | issue = 2 | pages = 143–52 | year = 2003 | pmid = 12600646 | doi = 10.1016/S1386-6532(02)00113-0 }}
- {{cite journal | vauthors = Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M | title = HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. | journal = J. Biosci. | volume = 28 | issue = 3 | pages = 323–35 | year = 2004 | pmid = 12734410 | doi = 10.1007/BF02970151 }}
- {{cite journal | vauthors = Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M | title = HIV/SIV escape from immune surveillance: focus on Nef. | journal = Curr. HIV Res. | volume = 2 | issue = 2 | pages = 141–51 | year = 2004 | pmid = 15078178 | doi = 10.2174/1570162043484924 }}
- {{cite journal | vauthors = Joseph AM, Kumar M, Mitra D | title = Nef: "necessary and enforcing factor" in HIV infection. | journal = Curr. HIV Res. | volume = 3 | issue = 1 | pages = 87–94 | year = 2005 | pmid = 15638726 | doi = 10.2174/1570162052773013 }}
- {{cite journal | vauthors = Stove V, Verhasselt B | title = Modelling thymic HIV-1 Nef effects. | journal = Curr. HIV Res. | volume = 4 | issue = 1 | pages = 57–64 | year = 2006 | pmid = 16454711 | doi = 10.2174/157016206775197583 }}
- {{cite journal | vauthors = Lichtenberg U, Quintrell N, Bishop JM | title = Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region. | journal = Oncogene | volume = 7 | issue = 5 | pages = 849–58 | year = 1992 | pmid = 1373873 | doi = }}
- {{cite journal | vauthors = Hradetzky D, Strebhardt K, Rübsamen-Waigmann H | title = The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family. | journal = Gene | volume = 113 | issue = 2 | pages = 275–80 | year = 1992 | pmid = 1572549 | doi = 10.1016/0378-1119(92)90407-G }}
- {{cite journal | vauthors = Kim JW, Sim SS, Kim UH, Nishibe S, Wahl MI, Carpenter G, Rhee SG | title = Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. | journal = J. Biol. Chem. | volume = 265 | issue = 7 | pages = 3940–3 | year = 1990 | pmid = 1689310 | doi = }}
- {{cite journal | vauthors = Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H | title = Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 23 | pages = 10411–5 | year = 1992 | pmid = 1720539 | pmc = 52938 | doi = 10.1073/pnas.88.23.10411 }}
- {{cite journal | vauthors = Lock P, Ralph S, Stanley E, Boulet I, Ramsay R, Dunn AR | title = Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. | journal = Mol. Cell. Biol. | volume = 11 | issue = 9 | pages = 4363–70 | year = 1991 | pmid = 1875927 | pmc = 361298 | doi = }}
- {{cite journal | vauthors = Ziegler SF, Marth JD, Lewis DB, Perlmutter RM | title = Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. | journal = Mol. Cell. Biol. | volume = 7 | issue = 6 | pages = 2276–85 | year = 1987 | pmid = 3453117 | pmc = 365352 | doi = }}
- {{cite journal | vauthors = Lee CH, Leung B, Lemmon MA, Zheng J, Cowburn D, Kuriyan J, Saksela K | title = A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. | journal = EMBO J. | volume = 14 | issue = 20 | pages = 5006–15 | year = 1995 | pmid = 7588629 | pmc = 394604 | doi = }}
- {{cite journal | vauthors = Liao F, Shin HS, Rhee SG | title = In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases. | journal = Biochem. Biophys. Res. Commun. | volume = 191 | issue = 3 | pages = 1028–33 | year = 1993 | pmid = 7682059 | doi = 10.1006/bbrc.1993.1320 | url = https://zenodo.org/record/1229412 | type = Submitted manuscript }}
- {{cite journal | vauthors = Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE | title = The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. | journal = J. Biol. Chem. | volume = 270 | issue = 24 | pages = 14718–24 | year = 1995 | pmid = 7782336 | doi = 10.1074/jbc.270.24.14718 }}
- {{cite journal | vauthors = Robbins SM, Quintrell NA, Bishop JM | title = Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. | journal = Mol. Cell. Biol. | volume = 15 | issue = 7 | pages = 3507–15 | year = 1995 | pmid = 7791757 | pmc = 230587 | doi = }}
- {{cite journal | vauthors = Saksela K, Cheng G, Baltimore D | title = Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. | journal = EMBO J. | volume = 14 | issue = 3 | pages = 484–91 | year = 1995 | pmid = 7859737 | pmc = 398106 | doi = }}
- {{cite journal | vauthors = Cheng G, Ye ZS, Baltimore D | title = Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 17 | pages = 8152–5 | year = 1994 | pmid = 8058772 | pmc = 44563 | doi = 10.1073/pnas.91.17.8152 }}
- {{cite journal | vauthors = Wang AV, Scholl PR, Geha RS | title = Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. | journal = J. Exp. Med. | volume = 180 | issue = 3 | pages = 1165–70 | year = 1994 | pmid = 8064233 | pmc = 2191633 | doi = 10.1084/jem.180.3.1165 }}
{{refend}}{{PDB Gallery|geneid=3055}}{{Tyrosine kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}} 1 : Tyrosine kinases |