| 词条 | Hepatitis C alternative reading frame stem-loop |
| 释义 |
| Name = Hepatitis C alternative reading frame stem-loop | image = RF00620.jpg | width = | caption = Predicted secondary structure and sequence conservation of HCV_ARF_SL | Symbol = HCV_ARF_SL | AltSymbols = | Rfam = RF00620 | miRBase = | miRBase_family = | RNA_type = Cis-reg | Tax_domain = Viruses | GO = | SO = {{SO|0000233}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome. The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures (IV and VII).[1] The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication.[1] The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression; these stem loops are located downstream of the Internal ribosome entry site (IRES) but their functional role is unknown.[1] See also
References1. ^1 2 {{cite journal |vauthors= McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD, Feinstone SM, Rice CM |title= Evidence for a functional RNA element in the hepatitis C virus coregene. |journal= Proc Natl Acad Sci USA |volume= 104 |issue= 8|pages= 2879–2884 |year= 2007 |pmid=17299041 |doi= 10.1073/pnas.0611267104 |pmc= 1815275|bibcode= 2007PNAS..104.2879M }} External links
2 : Cis-regulatory RNA elements|Hepatitis C virus |
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