| 词条 | Herpes simplex virus protein vmw65 |
| 释义 |
| Symbol = Alpha_TIF | Name = Alpha trans-inducing protein (Alpha-TIF) | image = PDB 16vp EBI.jpg | width = | caption = Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.[1] | Pfam = PF02232 | InterPro = IPR003174 | SMART = SM00814 | PROSITE = | SCOP = 16vp | TCDB = | OPM family = | OPM protein = | PDB = {{PDB2|16vp}} }}Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.[3][4] VP16 is a strong transactivator [5] and is often used in Y2H systems as the activation domain of the system.[6] References1. ^{{cite journal |vauthors=Liu Y, Gong W, Huang CC, Herr W, Cheng X |title=Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16 |journal=Genes Dev. |volume=13 |issue=13 |pages=1692–703 |date=July 1999 |pmid=10398682 |pmc=316849 |doi= 10.1101/gad.13.13.1692|url=}} {{Viral proteins}}{{DEFAULTSORT:Herpes Simplex Virus Protein Vmw65}}{{Virus-stub}}2. ^Entry for Vmw65 on Cure hunter 3. ^{{cite journal |vauthors=O'Reilly D, Hanscombe O, O'Hare P | title = A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II | journal = EMBO J. | volume = 16 | issue = 9 | pages = 2420–30 |date=May 1997 | pmid = 9171355 | pmc = 1169842 | doi = 10.1093/emboj/16.9.2420 | url = | issn = }} 4. ^{{cite journal |vauthors=Wysocka J, Herr W | title = The herpes simplex virus VP16-induced complex: the makings of a regulatory switch | journal = Trends Biochem. Sci. | volume = 28 | issue = 6 | pages = 294–304 |date=June 2003 | pmid = 12826401 | doi = 10.1016/S0968-0004(03)00088-4 | url = | issn = }} 5. ^{{cite journal |last1=Hirai |first1=Hiroyuki |last2=Tani |first2=Tetsuya |last3=Kikyo |first3=Nobuaki |title=Structure and functions of powerful transactivators: VP16, MyoD and FoxA |journal=The International Journal of Developmental Biology |date=2010 |volume=54 |issue=11–12 |pages=1589–1596 |doi=10.1387/ijdb.103194hh|pmid=21404180 |pmc=3419751 }} 6. ^{{cite journal |last1=Stynen |first1=B. |last2=Tournu |first2=H. |last3=Tavernier |first3=J. |last4=Van Dijck |first4=P. |title=Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System |journal=Microbiology and Molecular Biology Reviews |date=11 June 2012 |volume=76 |issue=2 |pages=331–382 |doi=10.1128/MMBR.05021-11|pmid=22688816 |pmc=3372256 }} 2 : Simplexviruses|Viral proteins |
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