| 词条 | Hippuristanol |
| 释义 |
| Watchedfields = changed | verifiedrevid = 407836689 | ImageFile=Hippuristanol.png | ImageSize=200px | IUPACName= | OtherNames= |Section1={{Chembox Identifiers | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1098427 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HPHXKNOXVBFETI-SHCCRYCOSA-N | SMILES1 = OC(C(=O)NNCNC(=O)c1ccccc1)(c2ccccc2)c3ccccc3 | InChI = 1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | InChIKey1 = HPHXKNOXVBFETI-SHCCRYCOSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=80442-78-0 | PubChem=5205637 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID=21105576 | SMILES=[H][C@@]23CC[C@@]1([H])C[C@H](O)CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@@](C[C@@]5([H])[C@@]([H])4[C@](O)(C)[C@]6(C[C@H](C)C(C)(C)O6)O5)3[H] |Section2={{Chembox Properties | C=28 | H=46 | O=5 | MolarMass=462.66 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Hippuristanol is a small molecule found in the coral Isis hippuris[1] which was discovered by Jerry Pelletier and others of McGill University in Montreal, Quebec, Canada.[2] It appears to have anti-viral activity and may hold promise as a cancer therapy.[3] Binds to and inhibits the eukaryotic translation initiation factor protein eIF4A.[4] See also
References1. ^{{cite journal | doi = 10.1038/nchembio776 | volume=2 | title=Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A | year=2006 | journal=Nature Chemical Biology | pages=213–220 | last1 = Bordeleau | first1 = Marie-Eve | last2 = Mori | first2 = Ayaka | last3 = Oberer | first3 = Monika | last4 = Lindqvist | first4 = Lisa | last5 = Chard | first5 = Louisa S | last6 = Higa | first6 = Tatsuo | last7 = Belsham | first7 = Graham J | last8 = Wagner | first8 = Gerhard | last9 = Tanaka | first9 = Junichi | last10 = Pelletier | first10 = Jerry}} 2. ^Killer Coral Compound, sciencebase 12 March 2006 3. ^Compound from Coral Could Combat Cancer Scientific American March 13, 2006 4. ^{{cite journal | last=Cencic | first=Regina | last2=Pelletier | first2=Jerry | title=Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A | journal=Translation | publisher=Informa UK Limited | volume=4 | issue=1 | date=2016-01-02 | issn=2169-0731 | doi=10.1080/21690731.2015.1137381 | page=e1137381| pmc=4909409 }} 1 : Steroids |
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