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词条 HIST4H4
释义

  1. References

  2. Further reading

{{Infobox_gene}}Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.[2]

References

1. ^{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc = | doi =10.1016/S0888-7543(02)96850-3 }}
2. ^{{cite web | title = Entrez Gene: HIST4H4 histone cluster 4, H4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=121504| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Pauli U, Chrysogelos S, Stein G, etal |title=Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. |journal=Science |volume=236 |issue= 4806 |pages= 1308–11 |year= 1987 |pmid= 3035717 |doi=10.1126/science.3035717 }}
  • {{cite journal |vauthors=Borowski P, Heiland M, Oehlmann K, etal |title=Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase. |journal=Eur. J. Biochem. |volume=237 |issue= 3 |pages= 611–8 |year= 1996 |pmid= 8647104 |doi=10.1111/j.1432-1033.1996.0611p.x }}
  • {{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
  • {{cite journal |vauthors=Zhang Y, Sun ZW, Iratni R, etal |title=SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex |journal=Mol. Cell |volume=1 |issue= 7 |pages= 1021–31 |year= 1998 |pmid= 9651585 |doi=10.1016/S1097-2765(00)80102-1 }}
  • {{cite journal |vauthors=Carrier F, Georgel PT, Pourquier P, etal |title=Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673–85 |year= 1999 |pmid= 10022855 |doi= | pmc=83961 }}
  • {{cite journal |vauthors=Buggy JJ, Sideris ML, Mak P, etal |title=Cloning and characterization of a novel human histone deacetylase, HDAC8 |journal=Biochem. J. |volume=350 Pt 1 |issue= Pt 1|pages= 199–205 |year= 2001 |pmid= 10926844 |doi= 10.1042/0264-6021:3500199| pmc=1221242 }}
  • {{cite journal |vauthors=Deng L, de la Fuente C, Fu P, etal |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
  • {{cite journal |vauthors=Chadwick BP, Willard HF |title=A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 375–84 |year= 2001 |pmid= 11266453 |doi=10.1083/jcb.152.2.375 | pmc=2199617 }}
  • {{cite journal |vauthors=Kovalsky O, Lung FD, Roller PP, Fornace AJ |title=Oligomerization of human Gadd45a protein |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39330–9 |year= 2001 |pmid= 11498536 |doi= 10.1074/jbc.M105115200 }}
  • {{cite journal |vauthors=Deng L, Wang D, de la Fuente C, etal |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
  • {{cite journal |vauthors=Lahn BT, Tang ZL, Zhou J, etal |title=Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8707–12 |year= 2002 |pmid= 12072557 |doi= 10.1073/pnas.082248899 | pmc=124363 }}
  • {{cite journal |vauthors=Ono S, Oue N, Kuniyasu H, etal |title=Acetylated histone H4 is reduced in human gastric adenomas and carcinomas |journal=J. Exp. Clin. Cancer Res. |volume=21 |issue= 3 |pages= 377–82 |year= 2003 |pmid= 12385581 |doi= }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Kzhyshkowska J, Rusch A, Wolf H, Dobner T |title=Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 385–93 |year= 2003 |pmid= 12489984 |doi= 10.1042/BJ20021281 | pmc=1223277 }}
  • {{cite journal |vauthors=Fujita K, Shimazaki N, Ohta Y, etal |title=Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone |journal=Genes Cells |volume=8 |issue= 6 |pages= 559–71 |year= 2004 |pmid= 12786946 |doi=10.1046/j.1365-2443.2003.00656.x }}
  • {{cite journal |vauthors=Shiio Y, Eisenman RN |title=Histone sumoylation is associated with transcriptional repression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 23 |pages= 13225–30 |year= 2004 |pmid= 14578449 |doi= 10.1073/pnas.1735528100 | pmc=263760 }}
  • {{cite journal |vauthors=Coleman MA, Miller KA, Beernink PT, etal |title=Identification of chromatin-related protein interactions using protein microarrays |journal=Proteomics |volume=3 |issue= 11 |pages= 2101–7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
  • {{cite journal |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 | pmc=291826 }}
  • {{cite journal |vauthors=Kanno T, Kanno Y, Siegel RM, etal |title=Selective recognition of acetylated histones by bromodomain proteins visualized in living cells |journal=Mol. Cell |volume=13 |issue= 1 |pages= 33–43 |year= 2004 |pmid= 14731392 |doi=10.1016/S1097-2765(03)00482-9 }}
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