“Histidine—tRNA ligase”的意思、由来-开放百科全书

词条

Histidine—tRNA ligase

释义

Nomenclature
See also
References

{{enzyme
| Name = histidine-tRNA ligase
| AltNames = histidyl tRNA synthetase, Jo-1
| EC_number = 6.1.1.21
| CAS_number = 9068-78-4
| IUBMB_EC_number = 6/1/1/21
| GO_code = 0004821
| image =
| width =
| caption =
}}

In enzymology, a histidine-tRNA ligase ({{EC number|6.1.1.21}}) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + tRNAHis AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Nomenclature

Histidine-tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.

References

{{cite journal | vauthors = von Tigerstrom M, Tener GM | year = 1967 | title = Histidyl transfer ribonucleic acid synthetase from bakers' yeast | journal = Can. J. Biochem. | volume = 45 | pages = 1067–74 | pmid = 6035970 | issue = 7 | doi=10.1139/o67-123}}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Histidine-tRNA ligase}}{{ligase-stub}}

2 : EC 6.1.1|Enzymes of known structure

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Nomenclature

See also

References