“History of polio”的意思、由来-开放百科全书

The history of polio (poliomyelitis) infections extends into prehistory. Although major polio epidemics were unknown before the 20th century,^[1] the disease has caused paralysis and death for much of human history. Over millennia, polio survived quietly as an endemic pathogen until the 1900s when major epidemics began to occur in Europe;^[1] soon after, widespread epidemics appeared in the United States. By 1910, frequent epidemics became regular events throughout the developed world, primarily in cities during the summer months. At its peak in the 1940s and 1950s, polio would paralyze or kill over half a million people worldwide every year.^[2]

The fear and the collective response to these epidemics would give rise to extraordinary public reaction and mobilization; spurring the development of new methods to prevent and treat the disease, and revolutionizing medical philanthropy. Although the development of two polio vaccines has eliminated poliomyelitis in all but three countries (Afghanistan, Pakistan and Nigeria),^[3] the legacy of poliomyelitis remains, in the development of modern rehabilitation therapy, and in the rise of disability rights movements worldwide.

Early history

The symptoms of poliomyelitis have been described by many names. In the early nineteenth century the disease was known variously as: Dental Paralysis, Infantile Spinal Paralysis, Essential Paralysis of Children, Regressive Paralysis, Myelitis of the Anterior Horns, Tephromyelitis (from the Greek tephros, meaning "ash-gray") and Paralysis of the Morning.^[9] In 1789 the first clinical description of poliomyelitis was provided by the British physician Michael Underwood—he refers to polio as "a debility of the lower extremities".^[10] The first medical report on poliomyelitis was by Jakob Heine, in 1840; he called the disease Lähmungszustände der unteren Extremitäten ("Paralysis of the lower Extremities").^[11] Karl Oskar Medin was the first to empirically study a poliomyelitis epidemic in 1890.^[12] This work, and the prior classification by Heine, led to the disease being known as Heine-Medin disease.

Epidemics

Major polio epidemics were unknown before the 20th century; localized paralytic polio epidemics began to appear in Europe and the United States around 1900.^[1] The first report of multiple polio cases was published in 1843 and described an 1841 outbreak in Louisiana. A fifty-year gap occurs before the next U.S. report—a cluster of 26 cases in Boston in 1893.^[1] The first recognized U.S. polio epidemic occurred the following year in Vermont with 132 total cases (18 deaths), including several cases in adults.^[12] Numerous epidemics of varying magnitude began to appear throughout the country; by 1907 approximately 2,500 cases of poliomyelitis were reported in New York City.^[13]

On Saturday, June 17, 1916, an official announcement of the existence an epidemic polio infection was made in Brooklyn, New York. That year, there were over 27,000 cases and more than 6,000 deaths due to polio in the United States, with over 2,000 deaths in New York City alone.^[15] The names and addresses of individuals with confirmed polio cases were published daily in the press, their houses were identified with placards, and their families were quarantined.^[16] Dr. Hiram M. Hiller, Jr. was one of the physicians in several cities who realized what they were dealing with, but the nature of the disease remained largely a mystery. The 1916 epidemic caused widespread panic and thousands fled the city to nearby mountain resorts; movie theaters were closed, meetings were canceled, public gatherings were almost nonexistent, and children were warned not to drink from water fountains, and told to avoid amusement parks, swimming pools, and beaches.^[15] From 1916 onward, a polio epidemic appeared each summer in at least one part of the country, with the most serious occurring in the 1940s and 1950s.^[1] In the epidemic of 1949, 2,720 deaths from the disease occurred in the United States and 42,173 cases were reported and Canada and the United Kingdom were also affected.^[17]^[18]

Prior to the 20th century polio infections were rarely seen in infants before 6 months of age and most cases occurred in children 6 months to 4 years of age.^[19] Young children who contract polio generally suffer only mild symptoms, but as a result they become permanently immune to the disease.^[20] In developed countries during the late 19th and early 20th centuries, improvements were being made in community sanitation, including improved sewage disposal and clean water supplies. Better hygiene meant that infants and young children had fewer opportunities to encounter and develop immunity to polio. Exposure to poliovirus was therefore delayed until late childhood or adult life, when it was more likely to take the paralytic form.^[19]

In children, paralysis due to polio occurs in one in 1000 cases, while in adults, paralysis occurs in one in 75 cases.^[21] By 1950, the peak age incidence of paralytic poliomyelitis in the United States had shifted from infants to children aged 5 to 9 years; about one-third of the cases were reported in persons over 15 years of age.^[22] Accordingly, the rate of paralysis and death due to polio infection also increased during this time.^[1] In the United States, the 1952 polio epidemic was the worst outbreak in the nation's history, and is credited with heightening parents’ fears of the disease and focusing public awareness on the need for a vaccine.^[23] Of the 57,628 cases reported that year 3,145 died and 21,269 were left with mild to disabling paralysis.^[23]^[24]

Historical treatments

In the early 20th century—in the absence of proven treatments—a number of odd and potentially dangerous polio treatments were suggested. In John Haven Emerson's A Monograph on the Epidemic of Poliomyelitis (Infantile Paralysis) in New York City in 1916^[25] one suggested remedy reads:

Following the 1916 epidemics and having experienced little success in treating polio patients, researchers set out to find new and better treatments for the disease. Between 1917 and the early 1950s several therapies were explored in an effort to prevent deformities including hydrotherapy and electrotherapy.{{Citation needed|date=January 2017}}

In 1935 Claus Jungeblut reported that vitamin C treatment inactivates the polio virus in vitro, making it non-infectious when injected into monkeys.^[27] In 1937, Jungeblut injected polio into the brains of monkeys, and found that many more monkeys that also received vitamin C escaped paralysis than controls - the results seemed to indicate that low doses were more effective than high doses.^[28] A subsequent study by Jungeblut demonstrated that polio infected monkeys had lower vitamin C levels than others, and that the monkeys that escaped paralysis had the highest vitamin C levels.^[29] Jungeblut subsequently confirmed his findings in a larger study, finding that natural vitamin C was more effective than synthetic vitamin C, and as the disease progressed, larger and larger amounts of vitamin C were needed for therapeutic effect.^[30]

In 1939, Albert Sabin reported that an experiment, employing the technique of "forcefully expelling the total amount [of Polio] in the direction of the olfactory mucosa, immediately drawing it back into the pipette, and repeating the process 2 to 3 times",^[31] was unable to confirm the results of Jungeblut, but found that "monkeys on a scorbutic diet died of spontaneous acute infections, chiefly pneumonia and enterocolitis, while their mates receiving an adequate diet remained well."^[32] Following this, Jungeblut found that "with an infection of maximum severity, induced by flooding the nasal portal of entry with large amounts of virus, vitamin C administration fails to exert any demonstrable influence on the course of the disease, but with a less forceful method of droplet instillation, the picture of the disease in control animals becomes so variable that the results cannot be easily interpreted; but the available data suggest that vitamin C treatment may be a factor in converting abortive attacks into an altogether non-paralytic infection."^[33] In 1979, R.J. Salo and D.O. Cliver inactivated Poliovirus type 1 by sodium bisulfite and ascorbic acid in an experiment.^[34]

In 1949-1953 Fred R. Klenner published his own clinical experience with vitamin C in the treatment of polio,^[35]^[36]^[37]^[38] however his work was not well received{{Citation needed|date=January 2017}} and no large clinical trials were ever performed.

Surgical treatments such as nerve grafting, tendon lengthening, tendon transfers, and limb lengthening and shortening were used extensively during this time.^[39]^[40] Patients with residual paralysis were treated with braces and taught to compensate for lost function with the help of calipers, crutches and wheelchairs. The use of devices such as rigid braces and body casts, which tended to cause muscle atrophy due to the limited movement of the user, were also touted as effective treatments.^[41] Massage and passive motion exercises were also used to treat polio victims.^[40] Most of these treatments proved to be of little therapeutic value, however several effective supportive measures for the treatment of polio did emerge during these decades including the iron lung, an anti-polio antibody serum, and a treatment regimen developed by Sister Elizabeth Kenny.^[42]

Iron lung

The first iron lung used in the treatment of polio victims was invented by Philip Drinker, Louis Agassiz Shaw, and James Wilson at Harvard, and tested October 12, 1928, at Children's Hospital, Boston.^[43] The original Drinker iron lung was powered by an electric motor attached to two vacuum cleaners, and worked by changing the pressure inside the machine. When the pressure is lowered, the chest cavity expands, trying to fill this partial vacuum. When the pressure is raised the chest cavity contracts. This expansion and contraction mimics the physiology of normal breathing. The design of the iron lung was subsequently improved by using a bellows attached directly to the machine, and John Haven Emerson modified the design to make production less expensive.^[43] The Emerson Iron Lung was produced until 1970.^[44] Other respiratory aids were used such as the Bragg-Paul Pulsator, and the "rocking bed" for patients with less critical breathing difficulties.^[45]

During the polio epidemics, the iron lung saved many thousands of lives, but the machine was large, cumbersome and very expensive:^[46] in the 1930s, an iron lung cost about $1,500—about the same price as the average home.^[47] The cost of running the machine was also prohibitive, as patients were encased in the metal chambers for months, years and sometimes for life:^[44] even with an iron lung the fatality rate for patients with bulbar polio exceeded 90%.^[48]

These drawbacks led to the development of more modern positive-pressure ventilators and the use of positive-pressure ventilation by tracheostomy. Positive pressure ventilators reduced mortality in bulbar patients from 90% to 20%.^[49] In the Copenhagen epidemic of 1952, large numbers of patients were ventilated by hand ("bagged") by medical students and anyone else on hand, because of the large number of bulbar polio patients and the small number of ventilators available.^[50]

Passive immunotherapy

In 1950 William Hammon at the University of Pittsburgh isolated serum, containing antibodies against poliovirus, from the blood of polio survivors.^[42] The serum, Hammon believed, would prevent the spread of polio and to reduce the severity of disease in polio patients.^[51] Between September 1951 and July 1952 nearly 55,000 children were involved in a clinical trial of the anti-polio serum.^[52] The results of the trial were promising; the serum was shown to be about 80% effective in preventing the development of paralytic poliomyelitis, and protection was shown to last for 5 weeks if given under tightly controlled circumstances.^[53] The serum was also shown to reduce the severity of the disease in patients who developed polio.^[42]

The large-scale use of antibody serum to prevent and treat polio had a number of drawbacks, however, including the observation that the immunity provided by the serum did not last long, and the protection offered by the antibody was incomplete, that re-injection was required during each epidemic outbreak, and that the optimal time frame for administration was unknown.^[51] The antibody serum was widely administered, but obtaining the serum was an expensive and time-consuming process, and the focus of the medical community soon shifted to the development of a polio vaccine.^[54]

Kenny regimen

Early management practices for paralyzed muscles emphasized the need to rest the affected muscles and suggested that the application of splints would prevent tightening of muscle, tendons, ligaments, or skin that would prevent normal movement. Many paralyzed polio patients lay in plaster body casts for months at a time. This prolonged casting often resulted in atrophy of both affected and unaffected muscles.^[4]

In 1940, Sister Elizabeth Kenny, an Australian bush nurse from Queensland, arrived in North America and challenged this approach to treatment. In treating polio cases in rural Australia between 1928 and 1940, Kenny had developed a form of physical therapy that—instead of immobilizing afflicted limbs—aimed to relieve pain and spasms in polio patients through the use of hot, moist packs to relieve muscle spasm and early activity and exercise to maximize the strength of unaffected muscle fibers and promote the neuroplastic recruitment of remaining nerve cells that had not been killed by the virus.^[41] Sister Kenny later settled in Minnesota where she established the Sister Kenny Rehabilitation Institute, beginning a world-wide crusade to advocate her system of treatment. Slowly, Kenny's ideas won acceptance, and by the mid-20th century had become the hallmark for the treatment of paralytic polio.^[39] In combination with antispasmodic medications to reduce muscular contractions, Kenny's therapy is still used in the treatment of paralytic poliomyelitis.

In 2009 as part of the Q150 celebrations, the Kenny regimen for polio treatment was announced as one of the Q150 Icons of Queensland for its role as an iconic "innovation and invention".^[55]

Vaccine development

In 1935 Maurice Brodie, a research assistant at New York University, attempted to produce a polio vaccine, procured from virus in ground up monkey spinal cords, and killed by formaldehyde. Brodie first tested the vaccine on himself and several of his assistants. He then gave the vaccine to three thousand children. Many developed allergic reactions, but none of the children developed an immunity to polio.^[56] During the late 1940s and early 1950s, a research group, headed by John Enders at the Boston Children's Hospital, successfully cultivated the poliovirus in human tissue. This significant breakthrough ultimately allowed for the development of the polio vaccines. Enders and his colleagues, Thomas H. Weller and Frederick C. Robbins, were recognized for their labors with the Nobel Prize in 1954.^[57]

Two vaccines are used throughout the world to combat polio. The first was developed by Jonas Salk, first tested in 1952, and announced to the world by Salk on April 12, 1955.^[54] The Salk vaccine, or inactivated poliovirus vaccine (IPV), consists of an injected dose of killed poliovirus. In 1954, the vaccine was tested for its ability to prevent polio; the field trials involving the Salk vaccine would grow to be the largest medical experiment in history. Immediately following licensing, vaccination campaigns were launched, by 1957, following mass immunizations promoted by the March of Dimes the annual number of polio cases in the United States was reduced, from a peak of nearly 58,000 cases, to 5,600 cases.^[12]

Eight years after Salk's success, Albert Sabin developed an oral polio vaccine (OPV) using live but weakened (attenuated) virus.^[58] Human trials of Sabin's vaccine began in 1957 and it was licensed in 1962. Following the development of oral polio vaccine, a second wave of mass immunizations led to a further decline in the number of cases: by 1961, only 161 cases were recorded in the United States.^[59] The last cases of paralytic poliomyelitis caused by endemic transmission of poliovirus in the United States were in 1979, when an outbreak occurred among the Amish in several Midwestern states.^[60]

Legacy

Early in the twentieth century polio became the world's most feared disease.{{Cn|date=April 2018}} The disease hit without warning, tended to strike white, affluent individuals, required long quarantine periods during which parents were separated from children: it was impossible to tell who would get the disease and who would be spared.^[12] The consequences of the disease left polio victims marked for life, leaving behind vivid images of wheelchairs, crutches, leg braces, breathing devices, and deformed limbs. However, polio changed not only the lives of those who survived it, but also affected profound cultural changes: the emergence of grassroots fund-raising campaigns that would revolutionize medical philanthropy, the rise of rehabilitation therapy and, through campaigns for the social and civil rights of the disabled, polio survivors helped to spur the modern disability rights movement.

In addition, the occurrence of polio epidemics led to a number of public health innovations. One of the most widespread was the proliferation of "no spitting" ordinances in the United States and elsewhere.^[61]

Philanthropy

In 1921 Franklin D. Roosevelt became totally and permanently paralyzed from the waist down. Although the paralysis (whether from poliomyelitis, as diagnosed at the time, or from Guillain–Barré syndrome) had no cure at the time, Roosevelt, who had planned a life in politics, refused to accept the limitations of his disease. He tried a wide range of therapies, including hydrotherapy in Warm Springs, Georgia (see below). In 1938 Roosevelt helped to found the National Foundation for Infantile Paralysis (now known as the March of Dimes), that raised money for the rehabilitation of victims of paralytic polio, and was instrumental in funding the development of polio vaccines. The March of Dimes changed the way it approached fund-raising. Rather than soliciting large contributions from a few wealthy individuals, the March of Dimes sought small donations from millions of individuals. Its hugely successful fund-raising campaigns collected hundreds of millions of dollars—more than all of the U.S. charities at the time combined (with the exception of the Red Cross).^[62] By 1955 the March of Dimes had invested $25.5 million in research;^[63] funding both Jonas Salk's and Albert Sabin's vaccine development; the 1954–55 field trial of vaccine, and supplies of free vaccine for thousands of children.^[47]

In 1952, during the worst recorded epidemic, 3,145 people in the United States died from polio.^[64] That same year over 200,000 people (including 4,000 children) died of cancer and 20,000 (including 1,500 children) died of tuberculosis.^[64] According to David Oshinsky's book Polio: An American Story: "There is evidence that the March of Dimes over-hyped polio, and promoted an image of immediately curable polio victims, which was not true. The March of Dimes refused to partner with other charity organizations like the United Way."^[62]

Rehabilitation therapy

Prior to the polio scares of the twentieth century, most rehabilitation therapy was focused on treating injured soldiers returning from war. The crippling effects of polio led to heightened awareness and public support of physical rehabilitation, and in response a number of rehabilitation centers specifically aimed at treating polio patients were opened, with the task of restoring and building the remaining strength of polio victims and teaching new, compensatory skills to large numbers of newly paralyzed individuals.^[46]

In 1926, Franklin Roosevelt, convinced of the benefits of hydrotherapy, bought a resort at Warm Springs, Georgia, where he founded the first modern rehabilitation center for treatment of polio patients which still operates as the Roosevelt Warm Springs Institute for Rehabilitation.^[65]

The cost of polio rehabilitation was often more than the average family could afford, and more than 80% of the nation's polio patients would receive funding through the March of Dimes.^[62] Some families also received support through philanthropic organizations such as the Ancient Arabic Order of the Nobles of the Mystic Shrine fraternity, which established a network of pediatric hospitals in 1919, the Shriners Hospitals for Children, to provide care free of charge for children with polio.^[66]

Disability rights movement

As thousands of polio survivors with varying degrees of paralysis left the rehabilitation hospitals and went home, to school and to work, many were frustrated by a lack of accessibility and discrimination they experienced in their communities. In the early twentieth century the use of a wheelchair at home or out in public was a daunting prospect as no public transportation system accommodated wheelchairs and most public buildings including schools, were inaccessible to those with disabilities. Many children left disabled by polio were forced to attend separate institutions for "crippled children" or had to be carried up and down stairs.^[65]

As people who had been paralyzed by polio matured, they began to demand the right to participate in the mainstream of society. Polio survivors were often in the forefront of the disability rights movement that emerged in the United States during the 1970s, and pushed legislation such as the Rehabilitation Act of 1973 which protected qualified individuals from discrimination based on their disability, and the Americans with Disabilities Act of 1990.^[65]^[67] Other political movements led by polio survivors include the Independent Living and Universal design movements of the 1960s and 1970s.^[68]

Polio survivors are one of the largest disabled groups in the world. The World Health Organization estimates that there are 10 to 20 million polio survivors worldwide.^[69] In 1977, the National Health Interview Survey reported that there were 254,000 people living in the United States who had been paralyzed by polio.^[70] According to local polio support groups and doctors, some 40,000 polio survivors with varying degrees of paralysis live in Germany, 30,000 in Japan, 24,000 in France, 16,000 in Australia, 12,000 in Canada and 12,000 in the United Kingdom.^[69]

See also

Notes and references

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2. ^{{cite web|title=What is Polio |publisher=Canadian International Immunization Initiative |url=http://www.immunize.cpha.ca/english/consumer/consrese/pdf/Polio.pdf |page=3 |accessdate=2007-05-09 |deadurl=yes |archiveurl=https://web.archive.org/web/20070929090612/http://www.immunize.cpha.ca/english/consumer/consrese/pdf/Polio.pdf |archivedate=September 29, 2007 }}
3. ^{{Cite web|url=http://www.who.int/mediacentre/factsheets/fs114/en/|title=Poliomyelitis|website=World Health Organization|language=en-GB|access-date=2016-04-13|deadurl=no|archiveurl=https://web.archive.org/web/20170418105535/http://www.who.int/mediacentre/factsheets/fs114/en/|archivedate=2017-04-18|df=}}
4. ^¹{{cite book |veditors=Daniel TM, Robbins FC |title=Polio |publisher=University of Rochester Press |location=Rochester, N.Y., USA |year=1997 |pages=5–22 |chapter= A history of poliomyelitis|isbn=1-878822-90-X |oclc= |doi=}}
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12. ^¹²³{{cite book |veditors=Sass EJ, Gottfried G, Sorem A |title=Polio's legacy: an oral history |publisher=University Press of America |location=Washington, D.C |year=1996 |isbn=0-7618-0144-8 |url=http://www.cloudnet.com/~edrbsass/poliotimeline.htm |deadurl=no |archiveurl=https://web.archive.org/web/20070403210215/http://www.cloudnet.com/~edrbsass/poliotimeline.htm |archivedate=2007-04-03 |df= }}
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14. ^Richard Rhodes (1990). A Hole in the World. Simon and Schuster.
15. ^¹{{cite journal |author=Melnick J |title=Current status of poliovirus infections |url=http://cmr.asm.org/cgi/reprint/9/3/293 |journal=Clin Microbiol Rev |volume=9 |issue=3 |pages=293–300 |date=1 July 1996 |pmid=8809461 |pmc=172894 |deadurl=no |archiveurl=https://web.archive.org/web/20110928101428/http://cmr.asm.org/cgi/reprint/9/3/293 |archivedate=28 September 2011 |df= }}
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19. ^¹{{cite web | author = Robertson S | title = Module 6: Poliomyelitis | work = The Immunological Basis for Immunization Series. | publisher = World Health Organization. Geneva, Switzerland. | url = http://whqlibdoc.who.int/hq/1993/WHO_EPI_GEN_93.16_mod6.pdf | year = 1993 | accessdate = 2014-01-13 | deadurl = no | archiveurl = https://web.archive.org/web/20110524151308/http://whqlibdoc.who.int/hq/1993/WHO_EPI_GEN_93.16_mod6.pdf | archivedate = 2011-05-24 | df = }}
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21. ^{{cite journal | vauthors = Gawne AC, Halstead LS | title = Post-polio syndrome: pathophysiology and clinical management | journal = Critical Reviews in Physical Medicine and Rehabilitation | year = 1995 | volume = 7 | pages = 147–88 | url = http://www.ott.zynet.co.uk/polio/lincolnshire/library/gawne/ppspandcm-s00.html | deadurl = yes | archiveurl = https://web.archive.org/web/20070806073707/http://www.ott.zynet.co.uk/polio/lincolnshire/library/gawne/ppspandcm-s00.html | archivedate = 2007-08-06 | df = }}
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23. ^¹{{cite web| url=http://www.historyofvaccines.org/content/timelines/diseases-and-vaccines#EVT_100309| title=History of Vaccines Website - Polio cases Surge| date=3 November 2010| accessdate=3 November 2010| publisher=College of Physicians of Philadelphia| deadurl=no| archiveurl=https://web.archive.org/web/20140701081956/http://www.historyofvaccines.org/content/timelines/diseases-and-vaccines#EVT_100309| archivedate=1 July 2014| df=}}
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54. ^¹{{cite news |author=Spice B |title=Tireless polio research effort bears fruit and indignation |url=http://www.post-gazette.com/pg/05094/482468.stm |work=The Salk vaccine: 50 years later- second of two parts |publisher=Pittsburgh Post-Gazette |date=2005-04-04 |accessdate=2010-02-07 |deadurl=no |archiveurl=https://web.archive.org/web/20080905022100/http://www.post-gazette.com/pg/05094/482468.stm |archivedate=2008-09-05 |df= }}
55. ^{{Cite web|url=http://statements.qld.gov.au/statement/id/64301|title=PREMIER UNVEILS QUEENSLAND’S 150 ICONS|last=Bligh|first=Anna|authorlink=Anna Bligh|date=10 June 2009|website=|publisher=Queensland Government|archive-url=https://web.archive.org/web/20170524033717/http://statements.qld.gov.au/statement/id/64301|archive-date=24 May 2017|dead-url=|access-date=24 May 2017}}
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57. ^{{cite web | title=The Nobel Prize in Physiology or Medicine 1954 | publisher=The Nobel Foundation | url=http://nobelprize.org/nobel_prizes/medicine/laureates/1954/ | accessdate=2010-02-07 | deadurl=no | archiveurl=https://web.archive.org/web/20081219224515/http://nobelprize.org/nobel_prizes/medicine/laureates/1954/ | archivedate=2008-12-19 | df= }}
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60. ^{{cite journal |title=Follow-up on poliomyelitis--United States, Canada, Netherlands. 1979 |url=https://www.cdc.gov/mmwr/preview/mmwrhtml/00050435.htm |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=46 |issue=50 |pages=1195–9 |year=1997 |pmid=9414151 |author1=Centers for Disease Control and Prevention (CDC) |deadurl=no |archiveurl=https://web.archive.org/web/20170625180759/https://www.cdc.gov/mmwr/preview/mmwrhtml/00050435.htm |archivedate=2017-06-25 |df= }}
61. ^See David M. Oshinsky, Polio: an American Story. Oxford University Press, 2005.
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69. ^¹{{cite web | url = http://www.marchofdimes.org/news/after-effects-of-polio-can-harm-survivors-40-years-later.aspx | title = After Effects of Polio Can Harm Survivors 40 Years Later | year = 2001 | work = March of Dimes: News Desk | accessdate = 2014-11-14 | deadurl = no | archiveurl = https://web.archive.org/web/20141225210413/http://www.marchofdimes.org/news/after-effects-of-polio-can-harm-survivors-40-years-later.aspx | archivedate = 2014-12-25 | df = }}
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