“HLA-DR13”的意思、由来-开放百科全书

词条

HLA-DR13

释义

Alleles
Disease associations
Extended linkage
Genetic Linkage
References


major histocompatibility complex, class II, DR13
Haplotypes groups	DQA01:DRB11301 to DQA01:DRB11309 DQA01:DRB11310 DQA01:DRB11312 ....
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1301 to 1308 *1310
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1301
EBI-HLA	DRB1*1302
EBI-HLA	DRB1*1304
EBI-HLA	DRB1*1306
EBI-HLA	DRB1*1307
EBI-HLA	DRB1*1310
Shared data
Locus	chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

Alleles

DR13, DR6 and other serotype recognition of some DRB1*13 alleles^[1]
DRB1*	DR13	DR6	DR14	Sample
allele	%	%	%	size (N)
1301	81	14	1	3788
1302	74	17	2	3081
1303	69	10	2	948^[2]
1304	87	127
1305	54	12	305^[3]
1306	78	9
1307	>50	1
1308	45	55	9
1310	>75	5

Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379

DRB1*13 allele group

81 Alleles: 74 proteins
DR13 (weak or no DR6) Serotype: 1301, 1302, 1304, 1306, 1307, 1310, 1312 to 1314
DR6 (weak DR13) Serotype: 1308
DR13&Other serotypes: 1303, 1305, 1311,
Serotype unknown: 1309, 1315 to 1374

Disease associations

DRB1*1302 is linked to early childhood myastenia gravis.^[4] Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

Extended linkage

DRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis^[4]

Genetic Linkage

DR13 Haplotypes
	DRA	DRB1	DRB3
DR13(6)-DR52	*0101	*1301	*0101
	*0101	*1301	*0201
	*0101	*1302	*0301
	DQA1	DQB1	DRB1
DR13(6)-DQ6(6.3, 1)	*0103	*0603	*1301
DR13(6)-DQ6(6.4, 1)	*0102	*0604	*1302
DR13(6)-DQ6(6.5, 1)	*0102	*0605	*1302
DR13(6)-DQ6(6.9, 1)	*0102	*0609	*1302
	HLA-A	HLA-B	DRB1
A2-Cw5-B44(16)-DR13	*02	*4402	*1301

HLA-DR13 is genetically linked to DR52^[5] and HLA-DQ6 (HLA-DQ1) serotypes.

References

1. ^derived from IMGT/HLA
2. ^DR12 - 3%, DR11 - 3% DR5-2%
3. ^DR12 - 6%, DR11 - 7% DR5-4%
4. ^¹{{cite journal |vauthors=Shinomiya N, Nomura Y, Segawa M | title = A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. | journal = Clin Immunol | volume = 110 | issue = 2 | pages = 154–8 | year = 2004 | pmid = 15003812 | doi = 10.1016/j.clim.2003.10.004}}
5. ^{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}}

1 : HLA-DR haplotypes

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