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词条 HLA-DR15
释义

  1. Serology

  2. Alleles

  3. Disease associations

     Extended linkage 

  4. Genetic Linkage

  5. References

major histocompatibility complex, class II, DR15
Haplotypes groupsDRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s)HLA-DRA
EBI-HLADRA*0101
Identifiers
beta 1 *1501 to *1505 *1507
Symbol(s)HLA-DRB1
EBI-HLADRB1*1501
EBI-HLADRB1*1502
EBI-HLADRB1*1503
EBI-HLADRB1*1504
EBI-HLADRB1*1505
EBI-HLADRB1*1507
Shared data
Locuschr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1*DR15DR2DR16Sample
allele % % % size (N)
1501 76 23 6428
1502 77 16 676
1503 81 13 286
1504 >50 1
1505 >25 2
1507 >50 1
{{clear|left}}

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522.

DRB1*1517N is a null.

Alleles

{{Empty section|date=July 2010}}

Disease associations

DR15 is positively associated Goodpasture syndrome,[2] early age onset multiple sclerosis,[3] pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7]

and a predisposition for postmenopausal osteoporosis.[8]

DRB1*1501 is positively associated with Goodpasture syndrome,[9][10] juvenile rheumatoid arthritis,[11] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] systemic lupus erythematosus,[14] cervical cancer (human papillomavirus infection),[15] Sjogren's syndrome associated with systemic lupus erythematosus,[16] and intermediate uveitis.[17]DRB1*1502 is associated with systemic lupus erythematosus,[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.[19]DRB1*1503 is associated with Chaga's cardiomyopathy,[20] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] cervical cancer (human papillomavirus infection).[23]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[21]DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[18]

Genetic Linkage

DR15 Haplotypes
SerotypesDRADRB1DRB5
DR15(2)-DR51*0101*1501*0101
*0101*1502*0101
*0101*1503*0101
*0101*1504*0101
*0101*1505*0101
*0101*1507*0101
DQA1DQB1DRB1
DR15(2)-DQ6(6.2, 1)*0102*0602*1501
DR15(2)-DQ6(6.1, 1)*0103*0601*1502
HLA-AHLA-BDRB1
A3-Cw7-B7-DR15(2)*0301*0702*1501
A1-B51-DR15(2)*0101*5101*1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

1. ^derived from IMGT/HLA
2. ^{{cite journal |vauthors=Phelps R, Jones V, Turner A, Rees A | title = Properties of HLA class II molecules divergently associated with Goodpasture's disease. | journal = Int Immunol | volume = 12 | issue = 8 | pages = 1135–43 | year = 2000 | pmid = 10917888 | doi = 10.1093/intimm/12.8.1135}}
3. ^{{cite journal |vauthors=Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J | title = HLA-DR15 is associated with lower age at onset in multiple sclerosis. | journal = Annals of Neurology | volume = 48 | issue = 2 | pages = 211–9 | year = 2000 | pmid = 10939572 | doi = 10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R}}
4. ^{{cite journal |vauthors=Ungar B, Mathews J, Tait B, Cowling D | title = HLA-DR patterns in pernicious anaemia | journal = Br Med J (Clin Res Ed) | volume = 282 | issue = 6266 | pages = 768–70 | year = 1981 | pmid = 6783164 | doi = 10.1136/bmj.282.6266.768 | pmc = 1504598}}
5. ^{{cite journal | author = Bilir M | title = Analysis of HLA antigens in Turkish sarcoidosis patients | journal = South. Med. J. | volume = 100 | issue = 4 | pages = 356–9 | year = 2007 | pmid = 17458393 | doi =10.1097/SMJ.0b013e31802f3763 |name-list-format=vanc| author2 = Sipahi S | author3 = Yilmaz E | display-authors = 3 | last4 = Midilli | first4 = K | last5 = Yanardag | first5 = H | last6 = Cagatay | first6 = T | last7 = Demirci | first7 = S | last8 = Karayel | first8 = T | last9 = Erdogan | first9 = E }}
6. ^{{cite journal |author=Hong SC |title=DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans |journal=Hum. Immunol. |volume=68 |issue=1 |pages=59–68 |date=January 2007 |pmid=17207713 |doi=10.1016/j.humimm.2006.10.006 |url= |name-list-format=vanc|author2=Lin L |author3=Lo B |display-authors=3 |last4=Jeong |first4=Jong-Hyun |last5=Shin |first5=Yoon-Kyung |last6=Kim |first6=Su-Yeon |last7=Kweon |first7=Yongsil |last8=Zhang |first8=Jing |last9=Einen |first9=Mali}}
7. ^{{cite journal |vauthors=Peled N, Amar A, Peled E, Brautbar C, Pillar G | title = DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients | journal = Sleep Med. | volume = 3 | issue = 3 | pages = 267–70 | year = 2002 | pmid = 14592217 | doi =10.1016/S1389-9457(01)00155-1 }}
8. ^{{cite journal | author = Douroudis K | title = HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population | journal = Tissue Antigens | volume = 69 | issue = 6 | pages = 592–6 | year = 2007 | pmid = 17498269 | doi = 10.1111/j.1399-0039.2007.00833.x |name-list-format=vanc| author2 = Tarassi K | author3 = Athanassiades T | display-authors = 3 | last4 = Giannakopoulos | first4 = F. | last5 = Kominakis | first5 = A. | last6 = Thalassinos | first6 = N. | last7 = Papasteriades | first7 = Ch.}}
9. ^{{cite journal |vauthors=Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y | title = Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis | journal = Kidney Int | volume = 68 | issue = 3 | pages = 1061–70 | year = 2005 | pmid = 16105036 | doi = 10.1111/j.1523-1755.2005.00498.x}}
10. ^{{cite journal |vauthors=Phelps R, Rees A | title = The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity | journal = Kidney Int | volume = 56 | issue = 5 | pages = 1638–53 | year = 1999 | pmid = 10571772 | doi = 10.1046/j.1523-1755.1999.00720.x}}
11. ^{{cite journal |vauthors=Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D | title = HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos | journal = Hum Immunol | volume = 65 | issue = 4 | pages = 359–65 | year = 2004 | pmid = 15120191 | doi = 10.1016/j.humimm.2004.01.016}}
12. ^1 {{cite journal |vauthors=Slavin R, Hutcheson P, Chauhan B, Bellone C | title = An overview of allergic bronchopulmonary aspergillosis with some new insights | journal = Allergy Asthma Proc | volume = 25 | issue = 6 | pages = 395–9 | year = 2004| pmid = 15709450}}
13. ^1 {{cite journal |vauthors=Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G | title = Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome | journal = Tissue Antigens | volume = 61 | issue = 2 | pages = 166–71 | year = 2003 | pmid = 12694585 | doi = 10.1046/j.0001-2815.2002.00008.x}}
14. ^{{cite journal |vauthors=Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K | title = Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients | journal = Int J Immunogenet | volume = 32 | issue = 3 | pages = 173–8 | year = 2005 | pmid = 15932622 | doi = 10.1111/j.1744-313X.2005.00504.x}}
15. ^{{cite journal |vauthors=Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C | title = HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity | journal = Nat Genet | volume = 6 | issue = 2 | pages = 157–62 | year = 1994 | pmid = 8162070 | doi = 10.1038/ng0294-157}}
16. ^{{cite journal |vauthors=Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H | title = Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome | journal = Arthritis Rheum | volume = 50 | issue = 3 | pages = 882–91 | year = 2004 | pmid = 15022331 | doi = 10.1002/art.20093}}
17. ^{{Cite journal|last=Petrushkin|first=Harry|last2=Thomas|first2=Dhanes|last3=Vaughan|first3=Robert|last4=Kondeatis|first4=Elli|last5=Stanford|first5=Miles R.|last6=Edelsten|first6=Clive|last7=Wallace|first7=Graham R.|date=2015-04-01|title=Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis|url=http://jamanetwork.com/journals/jamaophthalmology/fullarticle/2091789|journal=JAMA Ophthalmology|volume=133|issue=4|pages=482–483|doi=10.1001/jamaophthalmol.2014.5868|issn=2168-6165}}
18. ^1 {{cite journal |vauthors=Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K | title = Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais | journal = Tissue Antigens | volume = 59 | issue = 2 | pages = 113–7 | year = 2002 | pmid = 12028537 | doi = 10.1034/j.1399-0039.2002.590206.x}}
19. ^{{cite journal |vauthors=Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T | title = Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody | journal = Arthritis Rheum | volume = 42 | issue = 3 | pages = 465–74 | year = 1999 | pmid = 10088769 | doi = 10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y}}
20. ^{{cite journal |vauthors=García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A | title = HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection | journal = Ann Clin Biochem | volume = 43 | issue = Pt 3 | pages = 214–6 | year = 2006 | pmid = 16704757 | doi = 10.1258/000456306776865205}}
21. ^1 {{cite journal |vauthors=Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M | title = Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women | journal = Cancer Epidemiol Biomarkers Prev | volume = 9 | issue = 11 | pages = 1183–91 | year = 2000 | pmid = 11097225}}
{{DR serotypes}}{{DEFAULTSORT:Hla-Dr15}}

1 : HLA-DR haplotypes
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