“HLA-DR16”的意思、由来-开放百科全书

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

Alleles

Disease associations

DR16 is associated with Chaga's cardiomyopathy,^[2] rheumatic heart disease,^[3] coronary artery ectasia,^[4] and chronic discoid lupus erythematosus.^[5]

Extended linkage

Genetic Linkage

References

1. ^derived from IMGT/HLA
2. ^{{cite journal |vauthors=Cruz-Robles D, Reyes P, Monteón-Padilla V, Ortiz-Muñiz A, Vargas-Alarcón G | title = MHC class I and class II genes in Mexican patients with Chagas disease. | journal = Hum Immunol | volume = 65 | issue = 1 | pages = 60–5 | year = 2004 | pmid = 14700597 | doi = 10.1016/j.humimm.2003.10.008}}
3. ^¹²{{cite journal |vauthors=Hernández-Pacheco G, Aguilar-García J, Flores-Domínguez C, Rodríguez-Pérez J, Pérez-Hernández N, Alvarez-Leon E, Reyes P, Vargas-Alarcón G | title = MHC class II alleles in Mexican patients with rheumatic heart disease. | journal = Int J Cardiol | volume = 92 | issue = 1 | pages = 49–54 | year = 2003 | pmid = 14602216 | doi = 10.1016/S0167-5273(03)00040-8}}
4. ^{{cite journal |vauthors=Akdemir R, Ozhan H, Gunduz H, Erbilen E, Yazici M, Duran S, Orkunoglu F, Albayrak S, Imirzalioglu N, Uyan C | title = HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia. | journal = Acta Cardiol | volume = 59 | issue = 5 | pages = 499–502 | year = 2004 | pmid = 15529553 | doi = 10.2143/AC.59.5.2005222}}
5. ^{{cite journal |vauthors=López-Tello A, Rodríguez-Carreón AA, Jurado F, etal | title = Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients | journal = Clin. Exp. Dermatol. | volume = 32 | issue = 4 | pages = 435–8 | year = 2007 | pmid = 17376212 | doi = 10.1111/j.1365-2230.2007.02391.x}}
6. ^¹{{cite journal |vauthors=Dubaniewicz A, Moszkowska G, Szczerkowska Z | title = Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report. | journal = Tuberculosis (Edinb) | volume = 85 | issue = 4 | pages = 259–67 | year = 2005 | pmid = 15958261 | doi = 10.1016/j.tube.2004.12.003}}
7. ^{{cite journal |vauthors=Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D | title = HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. | journal = Hum Immunol | volume = 65 | issue = 4 | pages = 359–65 | year = 2004 | pmid = 15120191 | doi = 10.1016/j.humimm.2004.01.016}}
8. ^{{cite journal |vauthors=Salazar M, Varela A, Ramirez L, Uribe O, Vasquez G, Egea E, Yunis E, Iglesias-Gamarra A | title = Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry. | journal = Int J Cardiol | volume = 75 Suppl 1 | issue = | pages = S113–6 | year = 2000| pmid = 10980348}}
9. ^{{cite journal |vauthors=Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T | title = Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. | journal = Arthritis Rheum | volume = 42 | issue = 3 | pages = 465–74 | year = 1999 | pmid = 10088769 | doi = 10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y}}
10. ^¹{{cite journal |vauthors=Tan F, Stivers D, Arnett F, Chakraborty R, Howard R, Reveille J | title = HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis). | journal = Tissue Antigens | volume = 53 | issue = 1 | pages = 74–80 | year = 1999 | pmid = 10082433 | doi = 10.1034/j.1399-0039.1999.530108.x}}
11. ^{{cite journal |vauthors=Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S | title = HLA-DR and -DQ associations with melioidosis. | journal = Hum Immunol | volume = 59 | issue = 9 | pages = 580–6 | year = 1998 | pmid = 9757914 | doi = 10.1016/S0198-8859(98)00052-4}}
12. ^{{cite journal |vauthors=Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N | title = The association between HLA class II haplotype with Graves' disease in Thai population. | journal = Tissue Antigens | volume = 67 | issue = 1 | pages = 79–83 | year = 2006 | pmid = 16451208 | doi = 10.1111/j.1399-0039.2005.00498.x}}
13. ^{{cite journal |vauthors=Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B | title = Association of HLA-DR and -DQ genes with Graves disease in Koreans. | journal = Hum Immunol | volume = 66 | issue = 6 | pages = 741–7 | year = 2005 | pmid = 15993720 | doi = 10.1016/j.humimm.2005.03.001}}
14. ^{{cite journal |vauthors=Cervantes J, Lema C, Valentina Hurtado L, Andrade R, Hurtado Gomez L, Torrico L, Zegarra L, Quiroga G, Asturizaga D, Dulon A, Prada R, Panoso W, Yashiki S, Fujiyoshi T, Sonoda S | title = HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women. | journal = Hum Immunol | volume = 64 | issue = 9 | pages = 890–5 | year = 2003 | pmid = 12941545 | doi = 10.1016/S0198-8859(03)00163-0}}
15. ^{{cite journal | vauthors = Arnett F, Howard R, Tan F, Moulds J, Bias W, Durban E, Cameron H, Paxton G, Hodge T, Weathers P, Reveille J | title = Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. | journal = Arthritis Rheum | volume = 39 | issue = 8 | pages = 1362–70 | year = 1996 | pmid = 8702445 | doi = 10.1002/art.1780390814}}