“HLA-DR17”的意思、由来-开放百科全书

HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.

Serology

Disease associations

By serotype

DR17 is associated with non-chronic sarcoidosis,^[2]^[3] infantile spasm/epilepsy,^[4] rabies vaccine-induced autoimmune encephalomyelitis^[5] and cardiovascular hypertrophy in subjects with arterial hypertension^[6] People with DR17 show a tendency toward benzylpenicilloyl allergies.^[7]

By allele

DRB1*0301: diabetes mellitus type 1,^[8] myositis,^[9] early onset Graves disease,^[10] type 1 autoimmune hepatitis,^[11] inflammatory inclusion body myositis.^[12] In autoimmune hepatitis,

By haplotype

By phenotype

The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome^[20]

Genetic Linkage

are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.

This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"

References

1. ^derived from IMGT/HLA
2. ^{{cite journal |vauthors=Berlin M, Fogdell-Hahn A, Olerup O, Eklund A, Grunewald J | title = HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis. | journal = Am J Respir Crit Care Med | volume = 156 | issue = 5 | pages = 1601–5 | year = 1997 | pmid = 9372682 | doi=10.1164/ajrccm.156.5.9704069}}
3. ^{{cite journal |vauthors=Planck A, Katchar K, Eklund A, Gripenbäck S, Grunewald J | title = T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 20 | issue = 2 | pages = 110–7 | year = 2003 | pmid = 12870720}}
4. ^{{cite journal |vauthors=Suastegui R, De La Rosa G, Carranza J, Gonzalez-Astiazaran A, Gorodezky C | title = Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos. | journal = Epilepsia | volume = 42 | issue = 2 | pages = 210–5 | year = 2001 | pmid = 11240591 | doi = 10.1046/j.1528-1157.2001.22700.x}}
5. ^{{cite journal |vauthors=Piyasirisilp S, Schmeckpeper B, Chandanayingyong D, Hemachudha T, Griffin D | title = Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis. | journal = Ann Neurol | volume = 45 | issue = 5 | pages = 595–600 | year = 1999 | pmid = 10319881 | doi = 10.1002/1531-8249(199905)45:5<595::AID-ANA7>3.0.CO;2-M}}
6. ^{{cite journal |vauthors=Diamantopoulos E, Andreadis E, Vassilopoulos C, Vlachonikolis I, Tarassi K, Chatzis N, Giannakopoulos N, Papasteriades C | title = Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives. | journal = Am J Hypertens | volume = 14 | issue = 7 Pt 1 | pages = 632–6 | year = 2001 | pmid = 11465646 | doi = 10.1016/S0895-7061(01)01283-3}}
7. ^{{cite journal |vauthors=Yang J, Qiao HL, Zhang YW, Jia LJ, Tian X, Gao N | title = HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins | journal = Chin. Med. J. | volume = 119 | issue = 6 | pages = 458–66 | year = 2006 | pmid = 16584643 | doi = 10.1097/00029330-200603020-00005}}
8. ^{{cite journal |vauthors=Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M | title = HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients. | journal = Bratisl Lek Listy | volume = 107 | issue = 3 | pages = 76–9 | year = 2006 | pmid = 16796128}}
9. ^{{cite journal |vauthors=O'Hanlon T, Carrick D, Targoff I, Arnett F, Reveille J, Carrington M, Gao X, Oddis C, Morel P, Malley J, Malley K, Shamim E, Rider L, Chanock S, Foster C, Bunch T, Blackshear P, Plotz P, Love L, Miller F | title = Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. | journal = Medicine (Baltimore) | volume = 85 | issue = 2 | pages = 111–27 | year = 2006 | pmid = 16609350 | doi = 10.1097/01.md.0000217525.82287.eb}}
10. ^{{cite journal |vauthors=Lavard L, Madsen H, Perrild H, Jacobsen B, Svejgaard A | title = HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype. | journal = Tissue Antigens | volume = 50 | issue = 6 | pages = 639–41 | year = 1997 | pmid = 9458117 | doi = 10.1111/j.1399-0039.1997.tb02922.x}}
11. ^{{cite journal |vauthors=Czaja A, Strettell M, Thomson L, Santrach P, Moore S, Donaldson P, Williams R | title = Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis. | journal = Hepatology | volume = 25 | issue = 2 | pages = 317–23 | year = 1997 | pmid = 9021941 | doi = 10.1002/hep.510250211}}
12. ^{{cite journal |vauthors=Sivakumar K, Semino-Mora C, Dalakas M | title = An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families | journal = Brain | volume = 120 | issue = 4| pages = 653–61 | year = 1997| pmid = 9153127 | doi=10.1093/brain/120.4.653}}
13. ^{{cite journal |vauthors=Montano Loza AJ, Czaja AJ | title = Current therapy for autoimmune hepatitis | journal = Nature Clinical Practice Gastroenterology & Hepatology | volume = 4 | issue = 4 | pages = 202–14 | year = 2007 | pmid = 17404588 | doi = 10.1038/ncpgasthep0768}}
14. ^{{cite journal |vauthors=Deja G, Jarosz-Chobot P, Polańska J, Siekiera U, Małecka-Tendera E | title = Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? | journal = Mediators Inflamm | volume = 2006 | issue = 4 | pages = 1–7 | year = 2006 | pmid = 17047287 | doi = 10.1155/MI/2006/19724 | pmc = 1618952}}
15. ^{{cite journal |vauthors=Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K | title = HLA-class II haplotype associations with ovarian cancer | journal = Int J Cancer | volume = 119 | issue = 12 | pages = 2980–5 | year = 2006 | pmid = 17016821 | doi = 10.1002/ijc.22266}}
16. ^{{cite journal |vauthors=Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, Izbicki J | title = Correlation of thymic pathology with HLA in myasthenia gravis | journal = Clin Immunol | volume = 91 | issue = 3 | pages = 296–301 | year = 1999 | pmid = 10370374 | doi = 10.1006/clim.1999.4710}}
17. ^{{cite journal |vauthors=Shamim E, Rider L, Miller F | title = Update on the genetics of the idiopathic inflammatory myopathies | journal = Curr Opin Rheumatol | volume = 12 | issue = 6 | pages = 482–91 | year = 2000 | pmid = 11092196 | doi = 10.1097/00002281-200011000-00002}}
18. ^{{cite journal |vauthors=Parsons K, Kwok W, Gaur L, Nepom G | title = Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer | journal = Hum Immunol | volume = 61 | issue = 8 | pages = 828–33 | year = 2000 | pmid = 10980394 | doi = 10.1016/S0198-8859(00)00135-X}}
19. ^{{cite journal |vauthors=Grubić R, Žunec T, Peroš-Golubičić J, etal | title = HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1*0201 haplotype in clinical variations of the disease | journal = Tissue Antigens | volume = 70 | issue = 4 | pages = 301–6 | year = 2007 | doi = 10.1111/j.1399-0039.2007.00904.x | pmid = 17767551}}
20. ^{{cite journal |vauthors=Jean S, Quelvennec E, Alizadeh M, Guggenbuhl P, Birebent B, Perdriger A, Grosbois B, Pawlotsky P, Semana G | title = DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility | journal = Clin Exp Rheumatol | volume = 16 | issue = 6 | pages = 725–8 | year = 1998| pmid = 9844767}}