| 词条 | HLA-DR18 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia. Serology
DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3. Disease associationsDR18 seropositivity is associated with rheumatoid polyarthritis[2] DRB1*0302 is positively associated with juvenile diabetes,[3] nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.[4]Genetic Linkage
HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. References1. ^derived from IMGT/HLA {{DR serotypes}}{{DEFAULTSORT:Hla-Dr18}}2. ^{{cite journal |vauthors=Dieye A, Diallo S, Diatta M, Thiam A, Ndiaye R, Bao O, Sarthou J | title = [Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal] | journal = Dakar Med | volume = 42 | issue = 2 | pages = 111–3 | year = 1997 | pmid = 9827131}} 3. ^{{cite journal |vauthors=Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M | title = HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients | journal = Bratislavské lekárske listy | volume = 107 | issue = 3 | pages = 76–9 | year = 2006 | pmid = 16796128 | doi = }} 4. ^{{cite journal |vauthors=Sivakumar K, Semino-Mora C, Dalakas MC | title = An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families | journal = Brain | volume = 120 ( Pt 4) | issue = 4| pages = 653–661 | year = 1997 | pmid = 9153127 | doi =10.1093/brain/120.4.653 }} 1 : HLA-DR haplotypes |
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