| 词条 | HLA-DR4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world. Serology
The serological identification of DR4 is good. The serology of DRB1*04:17 to *04:60 is unknown. Disease associationsBy serotypeDR4 is associated with extraarticular[2] rheumatoid arthritis,[3] hydralazine-induced female systemic lupus erythematosus,[4] pemphigoid gestationis,[5] pemphigus foliaceus,[6] obstructive hypertrophic cardiomyopathy,[7] IgA nephropathy,[8] 'shared syndrome'-systemic sclerosis/rheumatoid arthritis[9] and polymyalgia rheumatica.[10] By alleleDRB1*04 is associated with increased risk for alopecia areata.[11] DRB1*04:01 is associated with multiple sclerosis,[12] rheumatoid arthritis,[13] type 1 diabetes,[14][15] lyme disease induced arthritis.[16]DRB1*04:02: drug-triggered[17]/idiopathic pemphigus vulgaris,[18][19] type 1 diabetes,[15] SLE associated anti-cardiolipin and anti-β2 glycoprotein I.[20]DRB1*04:03: polycystic ovary syndrome,[21] SLE associated anti-cardiolipin and anti-β2 glycoprotein I.[22]DRB1*04:04: anti-citrullinated fibrinogen[23] in rheumatoid arthritis,[13] autoimmune hepatitis.[24]DRB1*04:05: rheumatoid arthritis,[25] Autoimmune hepatitis,[26] type 1 diabetes.[14][15]DRB1*04:06: caspase-8 autoantibodies silicosis-systemic sclerosis (SSc)-systemic lupus erythematosus (SLE).[27]DRB1*04:09: T. cruzi infection with cardiomyopathy.[28]By haplotypeDR4-DQ8 is a risk factor for papillary thyroid carcinoma,[29] juvenile diabetes, coeliac disease and rheumatoid arthritis.[30]DRB1*04:DQA1*03:03-DQB1*04:01 haplotype: type III autoimmune polyglandular syndrome,[31] autoimmune hepatitis,[32] autoimmune pancreatitis.[33]DRB1*04:DQA1*03-DQB1*03:02 haplotype: Type 1 diabetes[34][35] with DRB1*04:01, *04:05, *04:02 increasing risk when DQ8 is present.[36]By genotypeDRB1*01:01/*04:04 and *01:01/*04:01 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking.[37] these same genotypes are associated with rheumatoid vasculitis.[38]Genetic linkage
References1. ^derived from IMGT/HLA {{DR serotypes}}{{DEFAULTSORT:Hla-Dr4}}2. ^{{cite journal | author = Roudier J | title = HLA-DRB1 genes and extraarticular rheumatoid arthritis | journal = Arthritis Research & Therapy | volume = 8 | issue = 1 | pages = 103 | year = 2006 | pmid = 16542468 | doi = 10.1186/ar1886 | pmc = 1526581}} 3. ^{{cite journal | author = Winchester R | title = Genetic aspects of rheumatoid arthritis | journal = Springer Semin Immunopathol | volume = 4 | issue = 2 | pages = 89–102 | year = 1981 | pmid = 6459655 | doi = 10.1007/BF01857089}} 4. ^{{cite journal |vauthors=Batchelor J, Welsh K, Tinoco R, Dollery C, Hughes G, Bernstein R, Ryan P, Naish P, Aber G, Bing R, Russell G | title = Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility | journal = Lancet | volume = 1 | issue = 8178 | pages = 1107–9 | year = 1980 | pmid = 6103441 | doi = 10.1016/S0140-6736(80)91554-8}} 5. ^{{cite journal |vauthors=Shornick J, Jenkins R, 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Erlich H, Brautbar C, Sanilevitch A, Landau M, Brenner S, Friedmann A | title = Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris | journal = Acta Derm Venereol | volume = 75 | issue = 1 | pages = 12–4 | year = 1995 | pmid = 7747528}} 18. ^{{cite journal |vauthors=Sáenz-Cantele AM, Fernández-Mestre M, Montagnani S, Calebotta A, Balbas O, Layrisse Z | title = HLA-DRB1*0402 haplotypes without DQB1*0302 in Venezuelan patients with pemphigus vulgaris | journal = Tissue Antigens | volume = 69 | issue = 4 | pages = 318–325 | year = 2007 | pmid = 17389015 | doi = 10.1111/j.1399-0039.2007.00826.x}} 19. ^{{cite journal |vauthors=Lee E, Lendas K, Chow S, Pirani Y, Gordon D, Dionisio R, Nguyen D, Spizuoco A, Fotino M, Zhang Y, Sinha A | title = Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris | journal = Hum Immunol | volume = 67 | issue = 1–2 | pages = 125–39 | year = 2006| pmid = 16698434 | doi = 10.1016/j.humimm.2005.09.003}} 20. ^{{cite journal |vauthors=Galeazzi M, Sebastiani G, Tincani A, Piette J, Allegri F, Morozzi G, Bellisai F, Scorza R, Ferrara G, Carcassi C, Font J, Passiu G, Smolen J, Papasteriades C, Houssiau F, Nebro A, Ramon Garrido E, Jedryka-Goral A, Marcolongo R | title = HLA class II alleles associations of anticardiolipin antibodies | journal = Lupus | volume = 9 | issue = 1 | pages = 47–55 | year = 2000 | pmid = 10715100 | doi=10.1177/096120330000900109 }} 21. ^{{cite journal |vauthors=Kaibe M, Takakuwa K, Murakawa H, Ishii K, Tamura M, Tanaka K | title = Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population--possible susceptibility of HLA-A11 and -DRB1*0403 to patient population with polycystic ovary syndrome | journal = Am J Reprod Immunol | volume = 55 | issue = 4 | pages = 301–6 | year = 2006 | pmid = 16533342 | doi = 10.1111/j.1600-0897.2006.00369.x}} 22. ^{{cite journal |vauthors=Galeazzi M, Sebastiani G, Tincani A, Piette J, Allegri F, Morozzi G, Bellisai F, Scorza R, Ferrara G, Carcassi C, Font J, Passiu G, Smolen J, Papasteriades C, Houssiau F, Nebro A, Ramon Garrido E, Jedryka-Goral A, Marcolongo R | title = HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus | journal = Lupus | volume = 9 | issue = 1 | pages = 47–55 | year = 2000 | pmid = 10715100 | doi = 10.1177/096120330000900109}} 23. ^{{cite journal |vauthors=Auger I, Sebbag M, Vincent C, Balandraud N, Guis S, Nogueira L, Svensson B, Cantagrel A, Serre G, Roudier J | title = Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrinogen | journal = Arthritis Rheum | volume = 52 | issue = 11 | pages = 3424–32 | year = 2005 | pmid = 16255019 | doi = 10.1002/art.21391}} 24. ^{{cite journal |vauthors=Vázquez-García M, Aláez 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pmid = 1350267 | doi = 10.1007/BF00209292}} 27. ^{{cite journal |vauthors=Ueki A, Isozaki Y, Kusaka M | title = Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles | journal = J Occup Health | volume = 47 | issue = 1 | pages = 61–7 | year = 2005 | pmid = 15703453 | doi = 10.1539/joh.47.61}} 28. ^{{cite journal |vauthors=García Borrás S, Diez C, Cotorruelo C, etal | title = HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection | journal = Ann. Clin. Biochem. | volume = 43 | issue = Pt 3 | pages = 214–6 | year = 2006 | pmid = 16704757 | doi = 10.1258/000456306776865205}} 29. ^{{cite journal |vauthors=Porto T, Coelho I, Boavida J, etal | title = Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas | journal = Clin. Endocrinol. | volume = 64 | issue = 2 | pages = 179–83 | year = 2006 | pmid = 16430717 | doi = 10.1111/j.1365-2265.2006.02445.x}} 30. ^{{cite journal |vauthors=Singal D, Green D, Reid B, Gladman D, Buchanan W | title = HLA-D region genes and rheumatoid arthritis (RA): importance of DR and DQ genes in conferring susceptibility to RA | journal = Ann Rheum Dis | volume = 51 | issue = 1 | pages = 23–8 | year = 1992 | pmid = 1371662 | doi = 10.1136/ard.51.1.23 | pmc = 1004612}} 31. ^{{cite journal |vauthors=Hashimoto K, Maruyama H, Nishiyama M, Asaba K, Ikeda Y, Takao T, Iwasaki Y, Kumon Y, Suehiro T, Tanimoto N, Mizobuchi M, Nakamura T | title = Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population | journal = Horm Res | volume = 64 | issue = 5 | pages = 253–60 | year = 2005 | pmid = 16254435 | doi = 10.1159/000089293}} 32. ^{{cite journal |vauthors=Yoshizawa K, Ota M, Katsuyama Y, Ichijo T, Matsumoto A, Tanaka E, Kiyosawa K | title = Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis | journal = J Hepatol | volume = 42 | issue = 4 | pages = 578–84 | year = 2005 | pmid = 15763345 | doi = 10.1016/j.jhep.2004.12.019}} 33. ^{{cite journal |vauthors=Kawa S, Ota M, Yoshizawa K, Horiuchi A, Hamano H, Ochi Y, Nakayama K, Tokutake Y, Katsuyama Y, Saito S, Hasebe O, Kiyosawa K | title = HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population | journal = Gastroenterology | volume = 122 | issue = 5 | pages = 1264–9 | year = 2002 | pmid = 11984513 | doi = 10.1053/gast.2002.33022}} 34. ^{{cite journal |vauthors=Park Y, Tait B, Kawasaki E, Rowley M, Mackay I | title = Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients | journal = Ann N Y Acad Sci | volume = 1037 | issue = | pages = 104–9 | year = 2004| pmid = 15699500 | doi = 10.1196/annals.1337.015}} 35. ^{{cite journal |vauthors=Hermann R, Turpeinen H, Laine A, Veijola R, Knip M, Simell O, Sipilä I, Akerblom H, Ilonen J | title = HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families | journal = Tissue Antigens | volume = 62 | issue = 2 | pages = 162–9 | year = 2003 | pmid = 12889996 | doi = 10.1034/j.1399-0039.2003.00071.x}} 36. ^{{cite journal |vauthors=Thomson G, Valdes AM, Noble JA, etal | title = Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis | journal = Tissue Antigens | volume = 70 | issue = 2 | pages = 110–27 | year = 2007 | pmid = 17610416 | doi = 10.1111/j.1399-0039.2007.00867.x}} 37. ^{{cite journal |vauthors=Mattey DL, Thomson W, Ollier WE, etal |title=Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study |journal=Arthritis Rheum. |volume=56 |issue=5 |pages=1408–16 |year=2007 |pmid=17469097 |doi=10.1002/art.22527}} 38. ^{{cite journal |vauthors=Gorman JD, David-Vaudey E, Pai M, Lum RF, Criswell LA |title=Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis |journal=Arthritis Rheum. |volume=50 |issue=11 |pages=3476–84 |year=2004 |pmid=15529352 |doi=10.1002/art.20588}} 1 : HLA-DR haplotypes |
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