“HLA-DR5”的意思、由来-开放百科全书

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy (PGL)^[3] and Kaposi sarcoma in AIDS,^[4] juvenile rheumatoid arthritis,^[5]^[6] pernicious anemia, Hashimoto's thyroiditis,^[7]^[8] mycosis fungoides,^[9] polyglandular deficiency syndrome,^[10] systemic sclerosis,^[11]^[12] childhood epilepsy,^[13] early-onset alopecia areata,^[14] short-ragweed Ra6 allergy,^[15] primary antiphospholipid syndrome,^[16] and increased longevity in the Dutch^[17]

Genetic linkage

References

1. ^derived from IMGT/HLA
2. ^DR8 - 2%
3. ^{{cite journal | doi = 10.1111/j.1399-0039.1987.tb01550.x |vauthors=Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J | title = HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia. | journal = Tissue Antigens | volume = 29 | issue = 1 | pages = 60–2 | year = 1987 | pmid = 3495904}}
4. ^{{cite journal | doi = 10.1111/j.1399-0039.1983.tb00364.x |vauthors=Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B | title = Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. | journal = Tissue Antigens | volume = 21 | issue = 1 | pages = 1–8 | year = 1983 | pmid = 6601312}}
5. ^{{cite journal |vauthors=Førre O, Dobloug J, Høyeraal H, Thorsby E | title = HLA antigens in juvenile arthritis. Genetic basis for the different subtypes. | journal = Arthritis Rheum | volume = 26 | issue = 1 | pages = 35–8 | year = 1983 | pmid = 6401993 | doi=10.1002/art.1780260106}}
6. ^{{cite journal |vauthors=Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C | title = HLA-DR5 in juvenile rheumatoid arthritis confined to few joints. | journal = Lancet | volume = 2 | issue = 8184 | pages = 40 | year = 1980 | pmid = 6104257 | doi=10.1016/S0140-6736(80)92920-7}}
7. ^{{cite journal | doi = 10.1111/j.1399-0039.1981.tb00700.x |vauthors=Farid N, Sampson L, Moens H, Barnard J | title = The association of goitrous autoimmune thyroiditis with HLA-DR5. | journal = Tissue Antigens | volume = 17 | issue = 3 | pages = 265–8 | year = 1981 | pmid = 6947505}}
8. ^{{cite journal |vauthors=Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K | title = HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. | journal = J Clin Endocrinol Metab | volume = 56 | issue = 4 | pages = 781–5 | year = 1983 | pmid = 6131902 | doi = 10.1210/jcem-56-4-781}}
9. ^{{cite journal |vauthors=Safai B, Myskowski P, Dupont B, Pollack M | title = Association of HLA-DR5 with mycosis fungoides. | journal = J Invest Dermatol | volume = 80 | issue = 5 | pages = 395–7 | year = 1983 | pmid = 6601679 | doi = 10.1111/1523-1747.ep12553615}}
10. ^{{cite journal |vauthors=Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L | title = The polyglandular deficiency syndrome: a new variant in Persian Jews. | journal = J Endocrinol Invest | volume = 10 | issue = 1 | pages = 1–7 | year = 1987 | pmid = 3496374 | doi=10.1007/bf03347139}}
11. ^{{cite journal |vauthors=Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N | title = Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families. | journal = J Rheumatol | volume = 14 | issue = 4 | pages = 760–5 | year = 1987 | pmid = 3499513}}
12. ^{{cite journal |vauthors=Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E | title = Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles. | journal = Arch Dermatol | volume = 123 | issue = 9 | pages = 1188–91 | year = 1987 | pmid = 3498440 | doi = 10.1001/archderm.123.9.1188}}
13. ^{{cite journal |vauthors=Minev M, Martinova F, Belopitova L | title = On the association of the HLA system with epilepsy in children. | journal = Epilepsia | volume = 28 | issue = 1 | pages = 74–6 | year = 1987| pmid = 3098558 | doi = 10.1111/j.1528-1157.1987.tb03626.x}}
14. ^{{cite journal |vauthors=Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G | title = Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata. | journal = Dermatologica | volume = 175 | issue = 1 | pages = 10–4 | year = 1987 | pmid = 3497062 | doi = 10.1159/000248775}}
15. ^{{cite journal |vauthors=Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M | title = Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans. | journal = Immunogenetics | volume = 26 | issue = 4–5 | pages = 230–6 | year = 1987 | pmid = 3498688 | doi = 10.1007/BF00346517}}
16. ^{{cite journal |vauthors=Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D | title = Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients | journal = Arthritis Rheum | volume = 38 | issue = 9 | pages = 1340–1 | year = 1995 | pmid = 7575732 | doi = 10.1002/art.1780380925}}
17. ^{{cite journal |vauthors=Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W | title = Longevity and heredity in humans. Association with the human leucocyte antigen phenotype | journal = Ann N Y Acad Sci | volume = 621 | issue = | pages = 78–89 | year = 1991| pmid = 1859103 | doi=10.1111/j.1749-6632.1991.tb16970.x}}