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词条 CNQX
释义

  1. See also

  2. References

  3. External links

{{chembox
| verifiedrevid = 443492699
| ImageFile=CNQX.svg
| ImageSize=240px
| IUPACName=7-nitro-2,3-dioxo-1,4-

dihydroquinoxaline-6-carbonitrile


| OtherNames=
|Section1={{Chembox Identifiers
| IUPHAR_ligand = 5475
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2951930
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C13668
| InChI = 1/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
| InChIKey = RPXVIAFEQBNEAX-UHFFFAOYAV
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 222418
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RPXVIAFEQBNEAX-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=115066-14-3
| PubChem=3721046
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6OTE87SCCW
| SMILES = [O-][N+](=O)c1c(C#N)cc2c(c1)NC(=O)C(=O)N2
}}
|Section2={{Chembox Properties
| Formula=C9H4N4O4
| MolarMass=232.15 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}CNQX or cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainate receptor antagonist. Its chemical formula is C9H4N4O4. CNQX is often used in the retina to block the responses of OFF-bipolar cells for electrophysiology recordings.[1]

See also

  • Quinoxalinedione

References

1. ^{{Cite journal|title = l-Glutamate-induced responses in OFF-type bipolar cells of the cat retina|url = http://www.sciencedirect.com/science/article/pii/004269899500176X|journal = Vision Research|date = 1996-03-01|pages = 787–795|volume = 36|issue = 6|doi = 10.1016/0042-6989(95)00176-X|first = Tsugihisa|last = Sasaki|first2 = Akimichi|last2 = Kaneko}}

External links

  • Imamachi et al. : The Non-NMDA Glutamate Receptor Antagonist CNQX Augments Lidocaine Antinociception Through a Spinal Action in Rats
  • Chemical structure
{{Ionotropic glutamate receptor modulators}}{{biochem-stub}}

7 : AMPA receptor antagonists|Kainate receptor antagonists|Nitriles|Nitro compounds|NMDA receptor antagonists|Quinoxalines|Lactams

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