| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.[1] Function This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Multiple alternatively spliced transcript variants have been described for this gene but only three variants have been fully described.[2] Interactions HNRPK has been shown to interact with: - CSK,[3]
- DDX1,[4]
- HNRNPL,[5]
- KHDRBS1,[5]
- PCBP2,[6]
- PRMT1,[7][8] and
- PTBP1.[6]
References 1. ^{{cite journal | vauthors = Dejgaard K, Leffers H, Rasmussen HH, Madsen P, Kruse TA, Gesser B, Nielsen H, Celis JE | title = Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing | journal = J Mol Biol | volume = 236 | issue = 1 | pages = 33–48 | date = March 1994 | pmid = 8107114 | pmc = | doi = 10.1006/jmbi.1994.1116 }}
2. ^{{cite web | title = Entrez Gene: HNRPK heterogeneous nuclear ribonucleoprotein K| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3190| accessdate = }}
3. ^{{cite journal | vauthors = Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW | title = c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs | journal = Mol. Cell. Biol. | volume = 22 | issue = 13 | pages = 4535–43 | date = July 2002 | pmid = 12052863 | pmc = 133888 | doi = 10.1128/mcb.22.13.4535-4543.2002}}
4. ^{{cite journal | vauthors = Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ | title = An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40403–9 | date = October 2002 | pmid = 12183465 | doi = 10.1074/jbc.M206981200 }}
5. ^{{cite journal | vauthors = Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F | title = Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K | journal = Oncogene | volume = 21 | issue = 47 | pages = 7187–94 | date = October 2002 | pmid = 12370808 | doi = 10.1038/sj.onc.1205759 }}
6. ^1 2 {{cite journal | vauthors = Kim JH, Hahm B, Kim YK, Choi M, Jang SK | title = Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm | journal = J. Mol. Biol. | volume = 298 | issue = 3 | pages = 395–405 | date = May 2000 | pmid = 10772858 | doi = 10.1006/jmbi.2000.3687 }}
7. ^{{cite journal | vauthors = Côté J, Boisvert FM, Boulanger MC, Bedford MT, Richard S | title = Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1 | journal = Mol. Biol. Cell | volume = 14 | issue = 1 | pages = 274–87 | date = January 2003 | pmid = 12529443 | pmc = 140244 | doi = 10.1091/mbc.E02-08-0484 }}
8. ^{{cite journal | vauthors = Wada K, Inoue K, Hagiwara M | title = Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy | journal = Biochim. Biophys. Acta | volume = 1591 | issue = 1-3 | pages = 1–10 | date = August 2002 | pmid = 12183049 | doi = 10.1016/s0167-4889(02)00202-1}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Bomsztyk K, Denisenko O, Ostrowski J | title = hnRNP K: one protein multiple processes | journal = BioEssays | volume = 26 | issue = 6 | pages = 629–38 | year = 2004 | pmid = 15170860 | doi = 10.1002/bies.20048 }}
- {{cite journal | vauthors = Matunis MJ, Michael WM, Dreyfuss G | title = Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein | journal = Mol. Cell. Biol. | volume = 12 | issue = 1 | pages = 164–71 | year = 1992 | pmid = 1729596 | pmc = 364080 | doi = }}
- {{cite journal | vauthors = Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS | title = Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains | journal = Mol. Cell. Biol. | volume = 14 | issue = 7 | pages = 4509–21 | year = 1994 | pmid = 7516469 | pmc = 358823 | doi = }}
- {{cite journal | vauthors = Bustelo XR, Suen KL, Michael WM, Dreyfuss G, Barbacid M | title = Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 3 | pages = 1324–32 | year = 1995 | pmid = 7862126 | pmc = 230356 | doi = }}
- {{cite journal | vauthors = Hobert O, Jallal B, Schlessinger J, Ullrich A | title = Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction | journal = J. Biol. Chem. | volume = 269 | issue = 32 | pages = 20225–8 | year = 1994 | pmid = 8051112 | doi = }}
- {{cite journal | vauthors = Aasheim HC, Loukianova T, Deggerdal A, Smeland EB | title = Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding oligo(dC) protein related to the pre-mRNA binding protein K | journal = Nucleic Acids Res. | volume = 22 | issue = 6 | pages = 959–64 | year = 1994 | pmid = 8152927 | pmc = 307915 | doi = 10.1093/nar/22.6.959 }}
- {{cite journal | vauthors = Buckanovich RJ, Posner JB, Darnell RB | title = Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system | journal = Neuron | volume = 11 | issue = 4 | pages = 657–72 | year = 1993 | pmid = 8398153 | doi = 10.1016/0896-6273(93)90077-5 }}
- {{cite journal | vauthors = Michelotti EF, Michelotti GA, Aronsohn AI, Levens D | title = Heterogeneous nuclear ribonucleoprotein K is a transcription factor | journal = Mol. Cell. Biol. | volume = 16 | issue = 5 | pages = 2350–60 | year = 1996 | pmid = 8628302 | pmc = 231223 | doi = }}
- {{cite journal | vauthors = Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ | title = Identification of Itk/Tsk Src homology 3 domain ligands | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25646–56 | year = 1996 | pmid = 8810341 | doi = 10.1074/jbc.271.41.25646 }}
- {{cite journal | vauthors = Tommerup N, Leffers H | title = Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A | journal = Genomics | volume = 32 | issue = 2 | pages = 297–8 | year = 1997 | pmid = 8833161 | doi = 10.1006/geno.1996.0121 }}
- {{cite journal | vauthors = Kai N, Mishina M, Yagi T | title = Molecular cloning of Fyn-associated molecules in the mouse central nervous system | journal = J. Neurosci. Res. | volume = 48 | issue = 5 | pages = 407–24 | year = 1997 | pmid = 9185665 | doi = 10.1002/(SICI)1097-4547(19970601)48:5<407::AID-JNR3>3.0.CO;2-I }}
- {{cite journal | vauthors = Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC | title = Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation | journal = J. Biol. Chem. | volume = 273 | issue = 17 | pages = 10784–91 | year = 1998 | pmid = 9553145 | doi = 10.1074/jbc.273.17.10784 }}
- {{cite journal | vauthors = Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM | title = Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17651–9 | year = 1998 | pmid = 9651361 | doi = 10.1074/jbc.273.28.17651 }}
- {{cite journal | vauthors = Schullery DS, Ostrowski J, Denisenko ON, Stempka L, Shnyreva M, Suzuki H, Gschwendt M, Bomsztyk K | title = Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein | journal = J. Biol. Chem. | volume = 274 | issue = 21 | pages = 15101–9 | year = 1999 | pmid = 10329716 | doi = 10.1074/jbc.274.21.15101 }}
- {{cite journal | vauthors = Baber JL, Libutti D, Levens D, Tjandra N | title = High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor | journal = J. Mol. Biol. | volume = 289 | issue = 4 | pages = 949–62 | year = 1999 | pmid = 10369774 | doi = 10.1006/jmbi.1999.2818 }}
- {{cite journal | vauthors = Wadd S, Bryant H, Filhol O, Scott JE, Hsieh TY, Everett RD, Clements JB | title = The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2 | journal = J. Biol. Chem. | volume = 274 | issue = 41 | pages = 28991–8 | year = 1999 | pmid = 10506147 | doi = 10.1074/jbc.274.41.28991 }}
- {{cite journal | vauthors = Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC | title = RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing | journal = Hum. Mol. Genet. | volume = 9 | issue = 5 | pages = 685–94 | year = 2000 | pmid = 10749975 | doi = 10.1093/hmg/9.5.685 }}
- {{cite journal | vauthors = Kim JH, Hahm B, Kim YK, Choi M, Jang SK | title = Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm | journal = J. Mol. Biol. | volume = 298 | issue = 3 | pages = 395–405 | year = 2000 | pmid = 10772858 | doi = 10.1006/jmbi.2000.3687 }}
- {{cite journal | vauthors = Shnyreva M, Schullery DS, Suzuki H, Higaki Y, Bomsztyk K | title = Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15498–503 | year = 2000 | pmid = 10809782 | doi = 10.1074/jbc.275.20.15498 }}
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