Holy shit may refer to:

• Holy Shit (band), a 2000s indie rock band formed by Matt Fishbeck and Ariel Pink
  • Holy Shit, 2003 self-titled EP
• Holy Shit (album), a 2011 album by Living with Lions
• "Holy Shit", a song by Father John Misty, appearing his 2015 album I Love You, Honeybear
• "Holy Shit!", a song by Against Me!, appearing on its 2005 album Searching for a Former Clarity
• "Holy shit", a jocular translation by art historian Cecila Klein of the divine excrement offered in the rites of Aztec goddess Tlazolteotl

• IFT80 (gene)
• IFT81 (gene)
• IFT88 (gene)
• Iftaari
• Ifta.ie
• Iftakar Chowdhury
• Iftari
• Ifta (river)
• IFTAS
• IFTAs
• I.F.T. (Breaking Bad)
• If Teardrops Were Silver
• Iftekhar Khan
• If That Isn't Love
• If That's the Way You Want It
• If That's What It Takes (Michael McDonald album)
• If the Cap Fits
• If the Fall Don't Get You
• If the Good Lord's Willing
• If the Good Lord's Willing and the Creek Don't Rise
• If The Good Lord's Willing and The Creek Don't Rise
• If The Good Lord's Willing and The Creek Don't Rise.
• If the Huns Came to Melbourne
• If the Lord Wasn't Walking by My Side
• If The Lord Wasn't Walking By My Side