| 词条 | Hormone response element |
| 释义 |
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signalled by the steroid hormone. A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2] HRE are used in transgenic animal cells as inducers of gene expression. Examples of HREs include estrogen response elements (EREs) and androgen response elements (AREs). References1. ^{{Cite web|url=http://www.biology-pages.info/S/SteroidREs.html|title=Steroid Hormone Receptors and their Response Elements|accessdate=2006-11-09}} {{genetics-stub}}2. ^{{cite book |author1=Monty Krieger |author2=Matthew P Scott |author3=Matsudaira, Paul T. |author4=Lodish, Harvey F. |author5=Darnell, James E. |author6=Lawrence Zipursky |author7=Kaiser, Chris |author8=Arnold Berk | title = Molecular Cell Biology, Fifth Edition | publisher = W. H. Freeman | location = San Francisco | year = 2003 | isbn = 0-7167-4366-3 | oclc = | doi = | page = 973 pages }} 1 : Gene expression |
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