| 释义 |
- Function
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2] Function This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3] Interactions HOXB7 has been shown to interact with PBX1[4] and CREB-binding protein.[5] See also References 1. ^{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = August 1990 | pmid = 1973146 | pmc = | doi = 10.1016/0888-7543(90)90186-X }}
2. ^{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = December 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}
3. ^{{cite web | title = Entrez Gene: HOXB7 homeobox B7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3217| accessdate = }}
4. ^{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–74 | date = March 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 }}
5. ^{{cite journal | vauthors = Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V | title = CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein | journal = Oncogene | volume = 18 | issue = 27 | pages = 4007–14 | date = July 1999 | pmid = 10435624 | doi = 10.1038/sj.onc.1202776 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Baier LJ, Hannibal MC, Hanley EW, Nabel GJ | title = Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain | journal = Blood | volume = 78 | issue = 4 | pages = 1047–55 | year = 1991 | pmid = 1678287 | doi = }}
- {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation | volume = 45 | issue = 1 | pages = 61–9 | year = 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
- {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation | volume = 40 | issue = 3 | pages = 191–7 | year = 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
- {{cite journal | vauthors = Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ | title = Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 21 | pages = 8536–40 | year = 1989 | pmid = 2573064 | pmc = 298317 | doi = 10.1073/pnas.86.21.8536 }}
- {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
- {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
- {{cite journal | vauthors = Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E | title = Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 14 | pages = 4914–8 | year = 1987 | pmid = 2885844 | pmc = 305217 | doi = 10.1073/pnas.84.14.4914 }}
- {{cite journal | vauthors = Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC | title = The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation | journal = Blood | volume = 85 | issue = 3 | pages = 692–7 | year = 1995 | pmid = 7530503 | doi = }}
- {{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–74 | year = 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 }}
- {{cite journal | vauthors = Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G | title = Nucleolar localisation of three Hox homeoproteins | journal = J. Cell Sci. | volume = 108 | issue = 1 | pages = 187–93 | year = 1995 | pmid = 7738096 | doi = }}
- {{cite journal | vauthors = Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H | title = Identification of homeobox genes expressed in human T-lymphocytes | journal = Biochem. Biophys. Res. Commun. | volume = 196 | issue = 1 | pages = 203–8 | year = 1993 | pmid = 8105782 | doi = 10.1006/bbrc.1993.2235 }}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM | title = Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 2 | pages = 900–5 | year = 1996 | pmid = 8570656 | pmc = 40155 | doi = 10.1073/pnas.93.2.900 }}
- {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1–2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
- {{cite journal | vauthors = Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP | title = HOXB7 constitutively activates basic fibroblast growth factor in melanomas | journal = Mol. Cell. Biol. | volume = 16 | issue = 9 | pages = 4842–51 | year = 1996 | pmid = 8756643 | pmc = 231486 | doi = 10.1128/mcb.16.9.4842}}
- {{cite journal | vauthors = LeBrun DP, Matthews BP, Feldman BJ, Cleary ML | title = The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains | journal = Oncogene | volume = 15 | issue = 17 | pages = 2059–67 | year = 1997 | pmid = 9366523 | doi = 10.1038/sj.onc.1201367 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C | title = HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development | journal = J. Invest. Dermatol. | volume = 110 | issue = 2 | pages = 110–5 | year = 1998 | pmid = 9457903 | doi = 10.1046/j.1523-1747.1998.00092.x }}
{{refend}} External links - {{MeshName|HOXB7+protein,+human}}
{{NLM content}}{{PDB Gallery|geneid=3217}}{{Transcription factors|g3}}{{gene-17-stub}} 1 : Transcription factors |