HRX may refer to:

• Zinc finger protein HRX, or simply HRX, an enzyme
• Hypo Real Estate (stock ticker symbol: HRX) a German company

hrx is the ISO 639 language code of Riograndenser Hunsrückisch German.

• Northridge Hospital Medical Center
• Northridge Local School District
• Northridge Mall (Milwaukee)
• Northridge Prep
• Northridge Preparatory School
• Northridge station
• Northridge University
• North Ridgeville High School
• Northriding
• North Riding of Lindsey
• North Riding of Yorkshire Constabulary
• North Riding of Yorkshire (UK Parliament constituency)
• North Rigton
• North Rim
• North Ringwood
• North Ringwood, Victoria
• NorthRiver
• North River (Alabama)
• North River (Cacapon River tributary)
• North Riverdale
• North Riverdale, Bronx, New York
• North River (Darien River tributary)
• North River (Deerfield River tributary)
• North River (disambiguation)
• North River (eastern Massachusetts)