| 词条 | Human placental lactogen |
| 释义 |
| Name = chorionic somatomammotropin hormone 1 (human placental lactogen) | caption = Crystal Structure of Human Placental Lactogen.[1] | image = 1Z7C.pdb.png | HGNCid = 2440 | Symbol = CSH1 | AltSymbols = | EntrezGene = 1442 | OMIM = 150200 | RefSeq = NM_001317 | UniProt = Q6PF11 | PDB = | ECnumber = | Chromosome = 17 | Arm = q | Band = 22 | LocusSupplementaryData = -q24 }}{{infobox protein | Name = chorionic somatomammotropin hormone 2 | caption = | image = | width = | HGNCid = 2441 | Symbol = CSH2 | AltSymbols = | EntrezGene = 1443 | OMIM = 118820 | RefSeq = NM_020991 | UniProt = P01243 | PDB = 1Z7C | ECnumber = | Chromosome = 17 | Arm = q | Band = 22 | LocusSupplementaryData = -q24 }}Human placental lactogen (hPL), also called human chorionic somatomammotropin (HCS), is a polypeptide placental hormone, the human form of placental lactogen (chorionic somatomammotropin). Its structure and function are similar to those of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. hPL has anti-insulin properties. hPL is a hormone secreted by the syncytiotrophoblast during pregnancy. Like human growth hormone, hPL is encoded by genes on chromosome 17q22-24. It was identified in 1963.[2] StructurehPL molecular mass is 22,125 and contains single chain consisting of 191 amino acid residues that are linked by two disulfide bonds and the structure contains 8 helices. A crystal structure of hPL was determined by X-ray diffraction to a resolution of 2.0 Å.[1] LevelshPL is present only during pregnancy, with maternal serum levels rising in relation to the growth of the fetus and placenta. Maximum levels are reached near term, typically to 5–7 mg/L (5-7 micrograms/ml)[3]. Higher levels are noted in patients with multiple gestation. Little hPL enters the fetal circulation. Its biological half-life is 15 minutes. Physiologic functionhPL affects the metabolic system of the maternal organism in the following manners:
These functions help support fetal nutrition even in the case of maternal malnutrition. hPL is a potent agonist of the prolactin receptor and a weak agonist of the growth hormone receptor.[4] Prolactin-like activityhPL has been found to bind to the prolactin receptor with equal affinity to that of prolactin in rabbit milk fat globule membrane, and hPL and prolactin have been found to possess very similar lactogenic activity in vitro in mouse and rat mammary gland explants.[5] In addition, hPL has been found to stimulate DNA synthesis in human mammary fibroadenoma cells transplanted into mice, which suggests that hPL promotes the growth of the human mammary gland similarly to prolactin.[5] As hPL circulates at concentrations that are 100-fold higher than those of prolactin during pregnancy, these findings suggest that hPL may play an important role in human mammogenesis during this time.[5] However, the relative affinities of hPL and prolactin for the human prolactin receptor have yet to be published and the effects of hPL on normal human mammary epithelial tissue have not yet been investigated, and so a definitive role of hPL in human mammary gland development during pregnancy has not been established at present.[5] Growth hormone-like activityhPL has weak actions similar to those of growth hormone, causing the formation of protein tissues in the same way that growth hormone, but 100 times more hPL than growth hormone is required to promote growth.[6] However, hPL has a blood level of more than 50 times that of hGH[7], hence its effects must not be ignored. An enhancer for the human placental lactogen gene is found 2 kb downstream of the gene and participates in the cell-specific control gene expression. Clinical measurementWhile hPL has been used as an indicator of fetal well-being and growth, other fetal testing methods have been found to be more reliable.{{citation needed|date=September 2012}} Also, normal pregnancies have been reported with undetectable maternal levels of hPL. See also
References1. ^1 {{PDB|1Z7C}}; {{cite journal |vauthors=Walsh ST, Kossiakoff AA | title = Crystal structure and site 1 binding energetics of human placental lactogen | journal = J. Mol. Biol. | volume = 358 | issue = 3 | pages = 773–84 |date=May 2006 | pmid = 16546209 | doi = 10.1016/j.jmb.2006.02.038 | url = | issn = }} 2. ^{{cite journal |vauthors=Josimovich JB, Atwood BL, Goss DA | title = Luteotrophic, Immunologic and Electrophoretic Properties of Human Placental Lactogen | journal = Endocrinology | volume = 73 | issue = | pages = 410–20 |date=October 1963 | pmid = 14068826 | doi = 10.1210/endo-73-4-410 }} 3. ^{{Cite web|url=https://www.medscape.com/viewarticle/408910_2|title=Medscape Log In|website=www.medscape.com|access-date=2018-03-23}} 4. ^{{cite book|author1=J. Larry Jameson|author2=Leslie J. De Groot|title=Endocrinology: Adult and Pediatric E-Book|url=https://books.google.com/books?id=xmLeBgAAQBAJ&pg=PA2490|date=25 February 2015|publisher=Elsevier Health Sciences|isbn=978-0-323-32195-2|pages=2490–}} 5. ^1 2 3 {{cite book|author=Margaret Neville|title=Lactation: Physiology, Nutrition, and Breast-Feeding|url=https://books.google.com/books?id=hNvTBwAAQBAJ&pg=PA150|date=11 November 2013|publisher=Springer Science & Business Media|isbn=978-1-4613-3688-4|pages=150–}} 6. ^{{cite book |author= Guyton and Hall |title=Textbook of Medical Physiology |edition=11 |publisher=Saunders |location=Philadelphia |year=2005 |origyear= |pages= 1033 |quote= This hormone has weak actions similar to those of growth hormone, causing the formation of protein tissues in the same way that growth hormone. |isbn=81-8147-920-3 |oclc= |doi= |url= |accessdate=}} 7. ^{{Cite journal|date=2016-06-01|title=Growth Hormone: Reference Range, Interpretation, Collection and Panels|url=https://emedicine.medscape.com/article/2089136-overview#a1}}
Further reading
External links
4 : Peptide hormones|Hormones of the placenta|Hormones of the pregnant female|Human female endocrine system |
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