“Hydroxymandelonitrile lyase”的意思、由来-开放百科全书

词条

Hydroxymandelonitrile lyase

释义

Structural studies
References

{{enzyme
| Name = hydroxymandelonitrile lyase
| EC_number = 4.1.2.11
| CAS_number = 9075-38-1
| IUBMB_EC_number = 4/1/2/11
| GO_code = 0050419
| image =
| width =
| caption =
}}

In enzymology, a hydroxymandelonitrile lyase ({{EC number|4.1.2.11}}) is an enzyme that catalyzes the chemical reaction

(S)-4-hydroxymandelonitrile cyanide + 4-hydroxybenzaldehyde

Hence, this enzyme has one substrate, (S)-4-hydroxymandelonitrile, and two products, cyanide and 4-hydroxybenzaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1GXS}}.

References

{{cite journal | author = AJ | date = 2006 | title = Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases | journal = Antimicrob. Agents Chemother. | volume = 50 | pages = 935–42 | pmid = 16495254 | doi = 10.1128/AAC.50.3.935-942.2006 | last2 = Shaw | first2 = PJ | last3 = Nath | first3 = CE | last4 = Yadav | first4 = SP | last5 = Stephen | first5 = KR | last6 = Earl | first6 = JW | last7 = McLachlan | first7 = AJ | issue = 3 | pmc = 1426421 }}
{{cite journal |vauthors=Seely MK, Criddle RS, Conn EE |author-link3=Eric Conn | date = 1966 | title = The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin | journal = J. Biol. Chem. | volume = 241 | pages = 4457–62 | pmid = 5922969 | issue = 19 }}

2 : EC 4.1.2|Enzymes of known structure

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