“Hydroxymethylglutaryl-CoA reductase (NADPH)”的意思、由来-开放百科全书

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Hydroxymethylglutaryl-CoA reductase (NADPH)

释义

Nomenclature
Structural studies
References

{{enzyme
| Name = hydroxymethylglutaryl-CoA reductase (NADPH)
| EC_number = 1.1.1.34
| CAS_number = 9028-35-7
| IUBMB_EC_number = 1/1/1/34
| GO_code = 0004420
| image = 1dqa.jpg
| width = 270
| caption = HMG-CoA reductase tetramer, Human
}}

In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) ({{EC number|1.1.1.34}}) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NADP⁺ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H⁺

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP⁺, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.

Nomenclature

The systematic name of this enzyme class is (R)-mevalonate:NADP⁺ oxidoreductase (CoA-acylating). Other names in common use include:

hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide
adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase
β-hydroxy-β-methylglutaryl coenzyme A reductase
hydroxymethylglutaryl CoA reductase (NADPH)
S-3-hydroxy-3-methylglutaryl-CoA reductase
NADPH-hydroxymethylglutaryl-CoA reductase
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
hydroxymethylglutaryl-CoA reductase (NADPH₂).

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DQ8}}, {{PDB link|1DQ9}}, {{PDB link|1DQA}}, {{PDB link|1HW8}}, {{PDB link|1HW9}}, {{PDB link|1HWI}}, {{PDB link|1HWJ}}, {{PDB link|1HWK}}, {{PDB link|1HWL}}, {{PDB link|2Q1L}}, {{PDB link|2Q6B}}, and {{PDB link|2Q6C}}.

References

{{cite journal | vauthors = Bucher NL, Overath P, Lynen F | date = 1960 | title = β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver | journal = Biochim. Biophys. Acta | volume = 40 | pages = 491–501 | doi = 10.1016/0006-3002(60)91390-1 | pmid=13805544}}
{{cite journal | vauthors = Durr IF, Rudney H | date = 1960 | title = The reduction of β-hydroxy-β-methyl-glutaryl coenzyme A to mevalonic acid | journal = J. Biol. Chem. | volume = 235 | pages = 2572–8 | pmid = 13818862 }}
{{cite journal | vauthors = Kawachi T, Rudney H | date = 1970 | title = Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver | journal = Biochemistry | volume = 9 | pages = 1700–5 | pmid = 4985697 | doi = 10.1021/bi00810a008 | issue = 8 }}

{{refend}}{{Alcohol oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.1.1-enzyme-stub}}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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