“Hydroxypyruvate reductase”的意思、由来-开放百科全书

词条

Hydroxypyruvate reductase

释义

References

{{enzyme
| Name = hydroxypyruvate reductase
| EC_number = 1.1.1.81
| CAS_number = 9059-44-3
| IUBMB_EC_number = 1/1/1/81
| GO_code = 0016618
| image =
| width =
| caption =
}}

In enzymology, a hydroxypyruvate reductase ({{EC number|1.1.1.81}}) is an enzyme that catalyzes the chemical reaction

D-glycerate + NAD(P)+ hydroxypyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-glycerate, NAD⁺, and NADP⁺, whereas its 4 products are hydroxypyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glycerate:NADP⁺ 2-oxidoreductase. Other names in common use include beta-hydroxypyruvate reductase, NADH:hydroxypyruvate reductase, and D-glycerate dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.

References

{{cite journal |author1 = Kleczkowski LA |author2 =Edwards GE | date = 1989 | title = Identification of hydroxypyruvate and glyoxylate reductases in maize leaves | journal = Plant Physiol. | volume = 91 | pages = 278–286 | doi = 10.1104/pp.91.1.278 | pmc = 1061987 }}
{{cite journal | vauthors = Kleczkowski LA, Randall DD | date = 1988 | title = Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases | journal = Biochem. J. | volume = 250 | pages = 145–52 | pmid = 3281657 | issue = 1 | pmc = 1148826 }}
{{cite journal | vauthors = Kohn LD, Jakoby WB | date = 1968 | title = Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase) | journal = J. Biol. Chem. | volume = 243 | pages = 2494–9 | pmid = 4385077 | issue = 10 }}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of known structure

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