词条 | Hy's law |
释义 |
Hy's Law cases have three components:[2]
In Zimmerman's analysis of 116 patients with hepatocellular injury and jaundice due to drug exposure, 76% went on to either require a liver transplant or died.[6] Other studies have reported a lower but still significant mortality of 10%.[7][8] References1. ^1 {{Cite web|url=http://www.fda.gov/downloads/drugs/scienceresearch/researchareas/ucm076783.pdf|title=Hy's Law Explained|last=Reuben|first=Adrian|date=March 26, 2008|website=fda.gov|publisher=|access-date=December 7, 2016}} {{treatment-stub}}2. ^1 United States Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER): Guidance for Industry Drug-Induced Liver Injury: Premarketing Clinical Evaluation, Final, July 2009 3. ^{{citation| journal= Gastroenterology |pages= 109–118 | date= July 2014 | title= Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury| pmid=24704526 | doi=10.1053/j.gastro.2014.03.050 | volume=147 |issue= 1 |vauthors=Robles-Diaz M, Lucena MI, Kaplowitz N, Stephens C, Medina-Cáliz I, González-Jimenez A, Ulzurrun E, Gonzalez AF, Fernandez MC, Romero-Gómez M, Jimenez-Perez M, Bruguera M, Prieto M, Bessone F, Hernandez N, Arrese M, Andrade RJ }} 4. ^{{citation| journal= Gastroenterology |pages= 452| date= Aug 2015 | title= Use of Hy's Law, R criteria, and nR criteria to predict acute liver failure or transplantation in patients with drug-induced liver injury.| pmid=25532807 | doi=10.1053/j.gastro.2014.11.046 | volume= 148|issue= 2|vauthors=Tansel A, Kanwal F, Hollinger FB }} 5. ^{{citation| journal= Pharmacoepidemiology and Drug Safety |pages= 235–239 | date= 22 March 2006| title= How can 'Hy's law' help the clinician?| doi=10.1002/pds.1210|pmid= 16552792 | volume=15|issue= 4 |last1= Senior |first1= John R. }} 6. ^{{Cite book|title=Hepatotoxicity|last=Zimmerman|first=Hyman|publisher=|year=1999|isbn=978-0781719520|location=|pages=|quote=|via=}} 7. ^{{Cite journal|last=Andrade|first=Raúl J.|last2=Lucena|first2=M. Isabel|last3=Fernández|first3=M. Carmen|last4=Pelaez|first4=Gloria|last5=Pachkoria|first5=Ketevan|last6=García-Ruiz|first6=Elena|last7=García-Muñoz|first7=Beatriz|last8=González-Grande|first8=Rocio|last9=Pizarro|first9=Angeles|date=2005-08-01|title=Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period|journal=Gastroenterology|volume=129|issue=2|pages=512–521|doi=10.1016/j.gastro.2005.05.006|issn=0016-5085|pmid=16083708}} 8. ^{{Cite journal|last=Björnsson|first=Einar|last2=Olsson|first2=Rolf|date=2005-08-01|title=Outcome and prognostic markers in severe drug-induced liver disease|journal=Hepatology|volume=42|issue=2|pages=481–489|doi=10.1002/hep.20800|issn=0270-9139|pmid=16025496}} 3 : Diseases of liver|Hepatology|Rules of thumb |
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