“ICAM2”的意思、由来-开放百科全书

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.^[1]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.^[2]

Interactions

Further reading

{{cite journal | vauthors = Simmons DL | title = The role of ICAM expression in immunity and disease | journal = Cancer Surveys | volume = 24 | issue = | pages = 141–55 | year = 1995 | pmid = 7553659 | doi = }}

{{cite journal | vauthors = Hayflick JS, Kilgannon P, Gallatin WM | title = The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions | journal = Immunologic Research | volume = 17 | issue = 3 | pages = 313–27 | year = 1998 | pmid = 9638475 | doi = 10.1007/BF02786454 }}

{{cite journal | vauthors = Lalor PF, Shields P, Grant A, Adams DH | title = Recruitment of lymphocytes to the human liver | journal = Immunology and Cell Biology | volume = 80 | issue = 1 | pages = 52–64 | date = February 2002 | pmid = 11869363 | doi = 10.1046/j.1440-1711.2002.01062.x }}

{{cite journal | vauthors = Yonekawa K, Harlan JM | title = Targeting leukocyte integrins in human diseases | journal = Journal of Leukocyte Biology | volume = 77 | issue = 2 | pages = 129–40 | date = February 2005 | pmid = 15548573 | doi = 10.1189/jlb.0804460 }}

{{cite journal | vauthors = de Fougerolles AR, Stacker SA, Schwarting R, Springer TA | title = Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1 | journal = The Journal of Experimental Medicine | volume = 174 | issue = 1 | pages = 253–67 | date = July 1991 | pmid = 1676048 | pmc = 2118873 | doi = 10.1084/jem.174.1.253 }}

{{cite journal | vauthors = Sansom D, Borrow J, Solomon E, Trowsdale J | title = The human ICAM2 gene maps to 17q23-25 | journal = Genomics | volume = 11 | issue = 2 | pages = 462–4 | date = October 1991 | pmid = 1769660 | doi = 10.1016/0888-7543(91)90157-A }}

{{cite journal | vauthors = Staunton DE, Dustin ML, Springer TA | title = Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1 | journal = Nature | volume = 339 | issue = 6219 | pages = 61–4 | date = May 1989 | pmid = 2497351 | doi = 10.1038/339061a0 }}

{{cite journal | vauthors = Bujía J, Holly A, Kim C, Scanady N, Kastenbauer E | title = Expression of human intercellular adhesion molecules in middle ear cholesteatoma | journal = American Journal of Otolaryngology | volume = 15 | issue = 4 | pages = 271–5 | year = 1994 | pmid = 7526720 | doi = 10.1016/0196-0709(94)90094-9 }}

{{cite journal | vauthors = de Fougerolles AR, Qin X, Springer TA | title = Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses | journal = The Journal of Experimental Medicine | volume = 179 | issue = 2 | pages = 619–29 | date = February 1994 | pmid = 7905020 | pmc = 2191386 | doi = 10.1084/jem.179.2.619 }}

{{cite journal | vauthors = Butini L, De Fougerolles AR, Vaccarezza M, Graziosi C, Cohen DI, Montroni M, Springer TA, Pantaleo G, Fauci AS | title = Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation | journal = European Journal of Immunology | volume = 24 | issue = 9 | pages = 2191–5 | date = September 1994 | pmid = 7916296 | doi = 10.1002/eji.1830240939 }}

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S, Tsukita S | title = Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway | journal = The Journal of Cell Biology | volume = 135 | issue = 1 | pages = 37–51 | date = October 1996 | pmid = 8858161 | pmc = 2121020 | doi = 10.1083/jcb.135.1.37 }}

{{cite journal | vauthors = Bernstein CN, Sargent M, Gallatin WM, Wilkins J | title = Beta 2-integrin/intercellular adhesion molecule (ICAM) expression in the normal human intestine | journal = Clinical and Experimental Immunology | volume = 106 | issue = 1 | pages = 160–9 | date = October 1996 | pmid = 8870715 | doi = }}

{{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}

{{cite journal | vauthors = Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH | title = Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface | journal = Nature | volume = 387 | issue = 6630 | pages = 312–5 | date = May 1997 | pmid = 9153399 | doi = 10.1038/387312a0 }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Sainio M, Zhao F, Heiska L, Turunen O, den Bakker M, Zwarthoff E, Lutchman M, Rouleau GA, Jääskeläinen J, Vaheri A, Carpén O | title = Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton | journal = Journal of Cell Science | volume = 110 | issue = 18| pages = 2249–60 | date = September 1997 | pmid = 9378774 | doi = | series = 110 }}

{{cite journal | vauthors = Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S | title = Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2 | journal = The Journal of Cell Biology | volume = 140 | issue = 4 | pages = 885–95 | date = February 1998 | pmid = 9472040 | pmc = 2141743 | doi = 10.1083/jcb.140.4.885 }}

{{cite journal | vauthors = Bernstein CN, Sargent M, Gallatin WM | title = Beta2 integrin/ICAM expression in Crohn's disease | journal = Clinical Immunology and Immunopathology | volume = 86 | issue = 2 | pages = 147–60 | date = February 1998 | pmid = 9473377 | doi = 10.1006/clin.1997.4462 }}

Protein structure

Protein functions

Interactions

See also

References

Further reading

External links