| 词条 | Ifood |
| 释义 |
Mechanism of protective effectOne of the most pernicious and irreparable types of oxidative damage inflicted by reactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction). Intriguingly, the biomolecules most damageable by this type of damage belong to the group of essential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); all polyunsaturated fatty acids). In theory, replacing hydrogen with deuterium "reinforces" the bond due to the kinetic isotope effect, and such reinforced biomolecules taken up by the body will be more resistant to ROS.[6] Deuterated omega-6 fatty acids for humans with degenerative diseasesThe company Retrotope pioneered the development a source of deuterated omega-6 fatty acid di-deuterated linoleic acid ethyl ester as a food additive for potential treatment of neurodegenerative diseases such as Friedreich’s ataxia and infantile neuroaxonal dystrophy. FDA has granted it an orphan drug designation and it passed the Phase I/II clinical trials (as of 2018).[7] Different from treatment with heavy waterAfter publication in scientific literature, the concept of isotopic food moved on to popular science publications[8] and even became a hot topic in mass media where the anti-ageing properties were often mistakenly attributed to heavy water.[9] See also
References1. ^https://www.newscientist.com/article/mg20827844.000-heavy-hydrogen-keeps-yeast-looking-good.html {{full|date=April 2018}} 2. ^{{cite journal |doi=10.1016/j.atherosclerosis.2017.07.018 |pmid=28756876 |title=Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first |journal=Atherosclerosis |volume=264 |pages=79–82 |year=2017 |last1=Tsikas |first1=Dimitrios }} 3. ^{{cite journal |doi=10.1007/s00726-017-2386-5 |pmid=28161800 |title=A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine |journal=Amino Acids |volume=49 |issue=5 |pages=887–894 |year=2017 |last1=Korneenko |first1=Tatyana V |last2=Pestov |first2=Nikolay B |last3=Hurski |first3=Alaksiej L |last4=Fedarkevich |first4=Artsiom M |last5=Shmanai |first5=Vadim V |last6=Brenna |first6=J. Thomas |last7=Shchepinov |first7=Mikhail S }} 4. ^{{cite journal |doi=10.1002/cbic.201600393 |pmid=27595234 |title=Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine |journal=ChemBioChem |volume=17 |issue=21 |pages=2018–2021 |year=2016 |last1=Woodcock |first1=Clayton B |last2=Ulashchik |first2=Egor A |last3=Poopeiko |first3=Nikolai E |last4=Shmanai |first4=Vadim V |last5=Reich |first5=Norbert O |last6=Shchepinov |first6=Mikhail S }} 5. ^{{cite journal |doi=10.1038/npjamd.2016.4 |pmid=28721263 |pmc=5515009 |title=Yeast longevity promoted by reversing aging-associated decline in heavy isotope content |journal=Npj Aging and Mechanisms of Disease |volume=2 |pages=16004 |year=2016 |last1=Li |first1=Xiyan |last2=Snyder |first2=Michael P }} 6. ^{{cite journal |doi=10.1089/rej.2006.0506 |pmid=17378752 |title=Reactive Oxygen Species, Isotope Effect, Essential Nutrients, and Enhanced Longevity |journal=Rejuvenation Research |volume=10 |issue=1 |pages=47–59 |year=2007 |last1=Shchepinov |first1=Mikhail S }} 7. ^{{cite journal |doi=10.1038/nbt0617-493 |pmid=28591114 |title=First deuterated drug approved |journal=Nature Biotechnology |volume=35 |issue=6 |pages=493–494 |year=2017 |last1=Schmidt |first1=Charles }} 8. ^Eat isotopes to live longer Gross M. 22 March 2007. Chemistry World. 9. ^http://news.softpedia.com/news/Anti-Aging-Elixir-Possibly-Discovered-98877.shtml {{full|date=April 2018}} External links
3 : Life extension|Nutrients|Hypotheses |
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