释义 |
- References
- Further reading
{{Infobox_gene}}Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene.[1][2][3]References1. ^{{cite journal |vauthors=Kiefer MC, Ioh RS, Bauer DM, Zapf J | title = Molecular cloning of a new human insulin-like growth factor binding protein | journal = Biochem Biophys Res Commun | volume = 176 | issue = 1 | pages = 219–25 |date=May 1991 | pmid = 1850258 | pmc = | doi =10.1016/0006-291X(91)90912-Q }} 2. ^{{cite journal |vauthors=Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H | title = Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene | journal = Mamm Genome | volume = 10 | issue = 4 | pages = 376–80 |date=May 1999 | pmid = 10087296 | pmc = | doi =10.1007/s003359901005 }} 3. ^{{cite web | title = Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3489| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Wood AW, Duan C, Bern HA |title=Insulin-like growth factor signaling in fish |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 215–85 |year= 2005 |pmid= 15797461 |doi= 10.1016/S0074-7696(05)43004-1 | series=International Review of Cytology | isbn=9780123646477 }}
- {{cite journal |vauthors=Zapf J, Kiefer M, Merryweather J, etal |title=Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 14892–8 |year= 1990 |pmid= 1697583 |doi= }}
- {{cite journal |vauthors=Kiefer MC, Masiarz FR, Bauer DM, Zapf J |title=Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum |journal=J. Biol. Chem. |volume=266 |issue= 14 |pages= 9043–9 |year= 1991 |pmid= 1709161 |doi= }}
- {{cite journal |vauthors=Shimasaki S, Gao L, Shimonaka M, Ling N |title=Isolation and molecular cloning of insulin-like growth factor-binding protein-6 |journal=Mol. Endocrinol. |volume=5 |issue= 7 |pages= 938–48 |year= 1991 |pmid= 1719383 |doi=10.1210/mend-5-7-938 }}
- {{cite journal |vauthors=Andress DL, Birnbaum RS |title=A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 1 |pages= 213–8 |year= 1991 |pmid= 1850257 |doi=10.1016/0006-291X(91)90911-P }}
- {{cite journal |vauthors=Martin JL, Willetts KE, Baxter RC |title=Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts |journal=J. Biol. Chem. |volume=265 |issue= 7 |pages= 4124–30 |year= 1990 |pmid= 2154495 |doi= }}
- {{cite journal |vauthors=Roghani M, Hossenlopp P, Lepage P, etal |title=Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II |journal=FEBS Lett. |volume=255 |issue= 2 |pages= 253–8 |year= 1989 |pmid= 2551732 |doi=10.1016/0014-5793(89)81101-9 }}
- {{cite journal |vauthors=Ilvesmäki V, Blum WF, Voutilainen R |title=Insulin-like growth factor binding proteins in the human adrenal gland |journal=Mol. Cell. Endocrinol. |volume=97 |issue= 1–2 |pages= 71–9 |year= 1994 |pmid= 7511544 |doi=10.1016/0303-7207(93)90212-3 }}
- {{cite journal |vauthors=Kato M, Ishizaki A, Hellman U, etal |title=A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12373–9 |year= 1995 |pmid= 7539002 |doi=10.1074/jbc.270.21.12373 }}
- {{cite journal |vauthors=Delhanty PJ, Hill DJ, Shimasaki S, Han VK |title=Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation? |journal=Growth Regul. |volume=3 |issue= 1 |pages= 8–11 |year= 1993 |pmid= 7683540 |doi= }}
- {{cite journal |vauthors=Bach LA, Hsieh S, Sakano K, etal |title=Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 |journal=J. Biol. Chem. |volume=268 |issue= 13 |pages= 9246–54 |year= 1993 |pmid= 7683646 |doi= }}
- {{cite journal |vauthors=Wegmann BR, Schöneberger HJ, Kiefer PE, etal |title=Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours |journal=Eur. J. Cancer |volume=29A |issue= 11 |pages= 1578–84 |year= 1993 |pmid= 7692907 |doi=10.1016/0959-8049(93)90298-T }}
- {{cite journal |vauthors=Neumann GM, Marinaro JA, Bach LA |title=Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6 |journal=Biochemistry |volume=37 |issue= 18 |pages= 6572–85 |year= 1998 |pmid= 9572875 |doi= 10.1021/bi972894e }}
- {{cite journal |vauthors=Neumann GM, Bach LA |title=The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14587–94 |year= 1999 |pmid= 10329650 |doi=10.1074/jbc.274.21.14587 }}
- {{cite journal |vauthors=Wong MS, Fong CC, Yang M |title=Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins |journal=Biochim. Biophys. Acta |volume=1432 |issue= 2 |pages= 293–301 |year= 1999 |pmid= 10407151 |doi=10.1016/S0167-4838(99)00106-5 }}
- {{cite journal |vauthors=Yu H, Mistry J, Nicar MJ, etal |title=Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation |journal=J. Clin. Lab. Anal. |volume=13 |issue= 4 |pages= 166–72 |year= 1999 |pmid= 10414596 |doi=10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X }}
- {{cite journal |vauthors=Dailly YP, Zhou Y, Linkhart TA, etal |title=Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1–2 |pages= 145–51 |year= 2001 |pmid= 11267670 |doi=10.1016/S0167-4781(01)00192-0 }}
- {{cite journal |vauthors=Weinzimer SA, Gibson TB, Collett-Solberg PF, etal |title=Transferrin is an insulin-like growth factor-binding protein-3 binding protein |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 4 |pages= 1806–13 |year= 2001 |pmid= 11297622 |doi=10.1210/jcem.86.4.7380 }}
{{refend}}{{PDB Gallery|geneid=3489}}{{Carrier proteins}}{{Growth factor receptor modulators}}{{gene-12-stub}} |