“Interleukin 29”的意思、由来-开放百科全书

IL-29 is a member of the helical cytokine family and is a type III interferon.^[3] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.

References

1. ^{{cite web | title = Entrez Gene: interleukin 29 (interferon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=282618| accessdate = }}
2. ^{{cite journal | vauthors = Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM | title = IL-28, IL-29 and their class II cytokine receptor IL-28R | journal = Nature Immunology | volume = 4 | issue = 1 | pages = 63–8 | date = January 2003 | pmid = 12469119 | doi = 10.1038/ni873 }}
3. ^{{cite journal | vauthors = Vilcek J | title = Novel interferons | journal = Nature Immunology | volume = 4 | issue = 1 | pages = 8–9 | date = January 2003 | pmid = 12496969 | doi = 10.1038/ni0103-8 }}

Further reading

{{cite journal | vauthors = Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD | title = Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit hepatitis C virus replication | journal = The Journal of Biological Chemistry | volume = 283 | issue = 44 | pages = 30079–89 | date = October 2008 | pmid = 18757365 | pmc = 2662072 | doi = 10.1074/jbc.M804296200 }}

{{cite journal | vauthors = Li MC, Wang HY, Wang HY, Li T, He SH | title = Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells | journal = Acta Pharmacologica Sinica | volume = 27 | issue = 4 | pages = 453–9 | date = April 2006 | pmid = 16539846 | doi = 10.1111/j.1745-7254.2006.00292.x }}

{{cite journal | vauthors = Megjugorac NJ, Gallagher GE, Gallagher G | title = Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29) | journal = Journal of Leukocyte Biology | volume = 86 | issue = 6 | pages = 1359–63 | date = December 2009 | pmid = 19759281 | doi = 10.1189/jlb.0509347 }}

{{cite journal | vauthors = Uzé G, Monneron D | title = IL-28 and IL-29: newcomers to the interferon family | journal = Biochimie | volume = 89 | issue = 6–7 | pages = 729–34 | year = 2007 | pmid = 17367910 | doi = 10.1016/j.biochi.2007.01.008 }}

{{cite journal | vauthors = Hou W, Wang X, Ye L, Zhou L, Yang ZQ, Riedel E, Ho WZ | title = Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages | journal = Journal of Virology | volume = 83 | issue = 8 | pages = 3834–42 | date = April 2009 | pmid = 19193806 | pmc = 2663280 | doi = 10.1128/JVI.01773-08 }}

{{cite journal | vauthors = Magracheva E, Pletnev S, Kotenko S, Li W, Wlodawer A, Zdanov A | title = Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor | journal = Acta Crystallographica Section F | volume = 66 | issue = Pt 1 | pages = 61–3 | date = January 2010 | pmid = 20057073 | pmc = 2805539 | doi = 10.1107/S1744309109048817 }}

{{cite journal | vauthors = Stoltz M, Klingström J | title = Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection | journal = Journal of Virology | volume = 84 | issue = 18 | pages = 9140–8 | date = September 2010 | pmid = 20592090 | pmc = 2937636 | doi = 10.1128/JVI.00717-10 }}

{{cite journal | vauthors = Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, Otte JM, Diebold J, Diepolder H, Adler B, Auernhammer CJ, Göke B, Dambacher J | title = IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 289 | issue = 5 | pages = G960–8 | date = November 2005 | pmid = 16051921 | doi = 10.1152/ajpgi.00126.2005 }}

{{cite journal | vauthors = Pekarek V, Srinivas S, Eskdale J, Gallagher G | title = Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner | journal = Genes and Immunity | volume = 8 | issue = 2 | pages = 177–80 | date = March 2007 | pmid = 17252004 | doi = 10.1038/sj.gene.6364372 }}

{{cite journal | vauthors = Li M, Liu X, Zhou Y, Su SB | title = Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses | journal = Journal of Leukocyte Biology | volume = 86 | issue = 1 | pages = 23–32 | date = July 2009 | pmid = 19304895 | doi = 10.1189/jlb.1208761 }}

{{cite journal | vauthors = Jordan WJ, Eskdale J, Boniotto M, Rodia M, Kellner D, Gallagher G | title = Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29) | journal = Genes and Immunity | volume = 8 | issue = 1 | pages = 13–20 | date = January 2007 | pmid = 17082759 | doi = 10.1038/sj.gene.6364348 }}

{{cite journal | vauthors = Wang J, Oberley-Deegan R, Wang S, Nikrad M, Funk CJ, Hartshorn KL, Mason RJ | title = Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection | journal = Journal of Immunology | volume = 182 | issue = 3 | pages = 1296–304 | date = February 2009 | pmid = 19155475 | pmc = 4041086 | doi = 10.4049/jimmunol.182.3.1296 }}

{{cite journal | vauthors = Lasfar A, Lewis-Antes A, Smirnov SV, Anantha S, Abushahba W, Tian B, Reuhl K, Dickensheets H, Sheikh F, Donnelly RP, Raveche E, Kotenko SV | title = Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma | journal = Cancer Research | volume = 66 | issue = 8 | pages = 4468–77 | date = April 2006 | pmid = 16618774 | doi = 10.1158/0008-5472.CAN-05-3653 }}

{{cite journal | vauthors = Osterlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, Julkunen I | title = Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells | journal = Journal of Virology | volume = 79 | issue = 15 | pages = 9608–17 | date = August 2005 | pmid = 16014923 | pmc = 1181545 | doi = 10.1128/JVI.79.15.9608-9617.2005 }}

{{cite journal | vauthors = Maher SG, Sheikh F, Scarzello AJ, Romero-Weaver AL, Baker DP, Donnelly RP, Gamero AM | title = IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity | journal = Cancer Biology & Therapy | volume = 7 | issue = 7 | pages = 1109–15 | date = July 2008 | pmid = 18698163 | pmc = 2435218 | doi = 10.4161/cbt.7.7.6192 }}

{{cite journal | vauthors = Mennechet FJ, Uzé G | title = Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells | journal = Blood | volume = 107 | issue = 11 | pages = 4417–23 | date = June 2006 | pmid = 16478884 | doi = 10.1182/blood-2005-10-4129 }}

{{cite journal | vauthors = Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R | title = Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes | journal = Journal of Leukocyte Biology | volume = 83 | issue = 5 | pages = 1181–93 | date = May 2008 | pmid = 18281438 | doi = 10.1189/jlb.0807525 }}

{{cite journal | vauthors = Novak AJ, Grote DM, Ziesmer SC, Rajkumar V, Doyle SE, Ansell SM | title = A role for IFN-lambda1 in multiple myeloma B cell growth | journal = Leukemia | volume = 22 | issue = 12 | pages = 2240–6 | date = December 2008 | pmid = 18830264 | pmc = 2771776 | doi = 10.1038/leu.2008.263 }}

{{cite journal | vauthors = Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K | title = Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines | journal = Genes and Immunity | volume = 10 | issue = 8 | pages = 702–14 | date = December 2009 | pmid = 19798076 | doi = 10.1038/gene.2009.72 }}

{{cite journal | vauthors = Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T, Bochud M, Battegay M, Bernasconi E, Borovicka J, Colombo S, Cerny A, Dufour JF, Furrer H, Günthard HF, Heim M, Hirschel B, Malinverni R, Moradpour D, Müllhaupt B, Witteck A, Beckmann JS, Berg T, Bergmann S, Negro F, Telenti A, Bochud PY | title = Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study | journal = Gastroenterology | volume = 138 | issue = 4 | pages = 1338–45, 1345.e1–7 | date = April 2010 | pmid = 20060832 | doi = 10.1053/j.gastro.2009.12.056 }}

1 : Interleukins