“Interleukin 32”的意思、由来-开放百科全书

词条

Interleukin 32

释义

Function
References

{{Infobox_gene}}Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene.^[1]

Function

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2.^[2]

IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.^[3]

References

1. ^¹{{cite web | title = Entrez Gene: Interleukin 32 | url = https://www.ncbi.nlm.nih.gov/gene/9235 }}
2. ^{{cite journal |vauthors=Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA | title = Interleukin-32: a cytokine and inducer of TNFalpha | journal = Immunity | volume = 22 | issue = 1 | pages = 131–42 |date=January 2005 | pmid = 15664165 | doi = 10.1016/j.immuni.2004.12.003 }}
3. ^{{cite journal |vauthors=Mabilleau G, Sabokbar A | title = Interleukin-32 promotes osteoclast differentiation but not osteoclast activation | journal = PLoS ONE | volume = 4 | issue = 1 | pages = e4173 | year = 2009 | pmid = 19137064 | pmc = 2613539 | doi = 10.1371/journal.pone.0004173 }}

1 : Interleukins

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