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词条 Intestinal permeability
释义

  1. Physiology

  2. Modulation

  3. Clinical significance

  4. Research directions

  5. Leaky gut syndrome

  6. See also

  7. References

Intestinal permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. The intestine normally exhibits some permeability, which allows nutrients to pass through the gut, while also maintaining a barrier function to keep potentially harmful substances (such as antigens) from leaving the intestine and migrating to the body more widely.[1] In a healthy human intestine, small particles (< 4 Å in radius) can migrate through tight junction claudin pore pathways,[2] and particles up to 10–15 Å (3.5 kDa) can transit through the paracellular space uptake route.[3]

Physiology

The barrier formed by the intestinal epithelium separates the external environment (the contents of the intestinal lumen) from the body[4] and is the most extensive and important mucosal surface of body.[5] The intestinal epithelium is composed of a single layer of cells and serves two crucial functions. First, it acts as a barrier, preventing the entry of harmful substances such as foreign antigens, toxins and microorganisms.[4][6] Second, it acts as a selective filter which facilitates the uptake of dietary nutrients, electrolytes, water and various other beneficial substances from the intestinal lumen.[4] Selective permeability is mediated via two major routes:[4]

  • Transepithelial or transcellular permeability. This consists of specific transport of solutes across the epithelial cells. It is predominantly regulated by the activities of specialised transporters that translocate specific electrolytes, amino acids, sugars, short chain fatty acids and other molecules into or out of the cell.[4]
  • Paracellular permeability. It depends on transport through the spaces that exist between epithelial cells. It is regulated by cellular junctions that are localized in the laminal membranes of the cells.[4] This is the main route of passive flow of water and solutes across the intestinal epithelium. Regulation depends on the intercellular tight junctions which have the most influence on paracellular transport.[7] Disruption of the tight junction barrier can be a trigger for the development of intestinal diseases.

Modulation

One way in which intestinal permeability is modulated is via CXCR3 receptors in cells in the intestinal epithelium, which respond to zonulin.[8]

Gliadin (a glycoprotein present in wheat) activates zonulin signaling in all people who eat gluten, irrespective of the genetic expression of autoimmunity. This lead to increased intestinal permeability to macromolecules.[8][15][9] Bacterial pathogens such as cholera, select enteric viruses, and parasites modulate intestinal tight junction structure and function, and these effects may contribute to the development of chronic intestinal disorders.[8][10] Stress and infections also seem to cause perturbations in intestinal permeability.[15]

Clinical significance

Most people do not experience adverse effects, but the opening of intercellular tight junctions (increased intestinal permeability) can act as a trigger for diseases that can affect any organ or tissue depending on genetic predisposition.[8][9][11] It can allow passage of microbes, microbial products, and foreign antigens into the mucosa and the body proper. This can result in activation of the immune system and secretion of inflammatory mediators.[12]

Increased intestinal permeability is a factor in several diseases, such as Crohn's disease, celiac disease,[13] type 1 diabetes,[14] type 2 diabetes,[13] rheumatoid arthritis, spondyloarthropathies,[15] inflammatory bowel disease,[8][31] irritable bowel syndrome,[16] schizophrenia,[17][18] certain types of cancer,[8] obesity,[19] fatty liver,[20] atopy and allergic diseases,[14] among others. In the majority of cases, increased permeability develops prior to disease,[8] but the cause–effect relationship between increased intestinal permeability in most of these diseases is not clear.[31][21]

A relationship with autism has been hypothesized but the data supporting this theory are limited and contradictory, since both increased intestinal permeability and normal permeability have been documented in people with autism. Studies with mice provide some support to this hypothesis.[22]

A well studied model is celiac disease, in which increased intestinal permeability appears secondary to the abnormal immune reaction induced by gluten and allows fragments of gliadin protein to get past the intestinal epithelium, triggering an immune response at the intestinal submucosa level that leads to diverse gastrointestinal or extra-gastrointestinal symptoms.[23][24] Other environmental triggers may contribute to alter permeability in celiac disease, as intestinal infections and iron deficiency.[23] Once established, this increase of permeability might self-sustain the inflammatory immune responses and perpetuate a vicious circle.[23] Eliminating gluten from the diet leads to normalization of intestinal permeability and the autoimmune process shuts off.[25]

Research directions

In normal physiology, glutamine plays a key role in signalling in enterocytes that are part of the intestinal barrier, but it is not clear if supplementing the diet with glutamine is helpful in conditions where there is increased intestinal permeability.[26]

Prebiotics and certain probiotics such as Escherichia coli Nissle 1917 have been found to reduce increased intestinal permeability.[16] Lactobacillus rhamnosus,[27] Lactobacillus reuteri,[27] and Faecalibacterium prausnitzii[28] have also been shown to significantly reduce increased intestinal permeability.

Larazotide acetate (previously known as AT-1001) is a zonulin receptor antagonist that has been probed in clinical trials. It seems to be a drug candidate for use in conjunction with a gluten-free diet in people with celiac disease, with the aim to reduce the intestinal permeability caused by gluten and its passage through the epithelium, and therefore mitigating the resulting cascade of immune reactions.[24][29]

Leaky gut syndrome

A proposed medical condition called leaky gut syndrome has been popularized by some health practitioners, mainly of alternative medicine and nutritionists, with claims that restoring normal functioning of the gut wall can cure many systemic health conditions. There is little evidence to support this claim and that so-called "treatments" for "leaky gut syndrome"—such as nutritional supplements, as those containing probiotics.;[16] herbal remedies; gluten-free foods; and low FODMAP, low sugar, or antifungal diets—have any beneficial effect for most of the conditions they are claimed to help.[30]

See also

  • Environmental enteropathy
  • Intestinal mucosal barrier

References

1. ^{{cite book|author1=M. Campieri|author2=C. Fiocchi|author3=S.B. Hanauer|title=Inflammatory Bowel Disease: A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment|url=https://books.google.com/books?id=vWJ7rY1Dkw0C&pg=PA7|date=31 March 2002|publisher=Springer|isbn=978-0-7923-8772-5|page=7}}
2. ^{{cite book|editor=Johnson LR|vauthors=Thoma YM, Anderson JM, Turner JR |work=Physiology of the Gastrointestinal Tract |volume=1 |url=https://books.google.com/books?id=ytWBLAy1FGQC&pg=PA1070 |year=2012| publisher=Academic Press| isbn=978-0-12-382027-3 |pages=1043– |title=Tight Junctions and the Intestinal Barrier|display-editors=etal}}
3. ^1 {{cite journal |author=Fasano, A. |authorlink=Alessio Fasano |title=Leaky Gut and Autoimmune Diseases |journal=Clinical Reviews in Allergy & Immunology|volume=42 |issue=1 |pages=71–78 |date=February 2012 |pmid=22109896 |doi=10.1007/s12016-011-8291-x|type=Review}}
4. ^1 2 3 4 5 {{Cite journal|last=Groschwitz|first=Katherine R.|last2=Hogan|first2=Simon P.|date=2009-07-01|title=Intestinal Barrier Function: Molecular Regulation and Disease Pathogenesis|journal=Journal of Allergy and Clinical Immunology|volume=124|issue=1|pages=3–22|doi=10.1016/j.jaci.2009.05.038|pmc=4266989|pmid=19560575}}
5. ^{{Cite journal|last=Rao|first=Jaladanki N.|last2=Wang|first2=Jian-Ying|date=2010-01-01|title=Intestinal Architecture and Development|url=https://www.ncbi.nlm.nih.gov/books/NBK54098/|language=en|publisher=Morgan & Claypool Life Sciences}}
6. ^{{Cite journal|last=Khan|first=Niamat|last2=Asif|first2=Abdul R.|date=2015-01-01|title=Transcriptional Regulators of Claudins in Epithelial Tight Junctions|journal=Mediators of Inflammation|volume=2015|doi=10.1155/2015/219843|pmc=4407569|pmid=25948882|pages=219843}}
7. ^{{Cite journal|last=Näslund|first=Erik|last2=Hellström|first2=Per M.|date=2007-09-10|title=Appetite signaling: from gut peptides and enteric nerves to brain|journal=Physiology & Behavior|volume=92|issue=1–2|pages=256–262|doi=10.1016/j.physbeh.2007.05.017|pmid=17582445}}
8. ^1 2 3 4 5 6 7 {{cite journal | author = Fasano A | date = Jan 2011 | title = Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer | url = | journal = Physiological Reviews| volume = 91 | issue = 1| pages = 151–75 | doi = 10.1152/physrev.00003.2008 | pmid = 21248165 | type = Review| citeseerx = 10.1.1.653.3967 }}
9. ^1 {{cite journal| vauthors=Leonard MM, Sapone A, Catassi C, Fasano A| title=Celiac Disease and Nonceliac Gluten Sensitivity: A Review | journal=JAMA| year= 2017 | volume= 318 | issue= 7 | pages= 647–656 | pmid=28810029 | doi=10.1001/jama.2017.9730 | type=Review | quote=Previous studies have shown that gliadin can cause an immediate and transient increase in gut permeability. This permeating effect is secondary to the binding of specific undigestible gliadin fragments to the CXCR3 chemokine receptor with subsequent release of zonulin, a modulator of intercellular tight junctions. This process takes place in all individuals who ingest gluten. For the majority, these events do not lead to abnormal consequences. However, these same events can lead to an inflammatory process in genetically predisposed individuals when the immunologic surveillance system mistakenly recognizes gluten as a pathogen. }}
10. ^{{cite journal |doi=10.2741/3206 |title=Mechanisms of intestinal tight junctional disruption during infection |year=2008 |last1=O'Hara|first1= JR |last2=Buret|first2=AG|journal=Frontiers in Bioscience|issue= 13|pages=7008–21|pmid=18508712 |volume=13}}
11. ^{{Cite journal|last=Suzuki|first=Takuya|date=2013-02-01|title=Regulation of intestinal epithelial permeability by tight junctions|journal=Cellular and Molecular Life Sciences|language=en|volume=70|issue=4|pages=631–659|doi=10.1007/s00018-012-1070-x|pmid=22782113}}
12. ^{{Cite journal|title=Gut epithelial barrier dysfunction in human immunodeficiency virus-hepatitis C virus coinfected patients: Influence on innate and acquired immunity. | pmid=26819512 | doi=10.3748/wjg.v22.i4.1433 | volume=22 | issue=4 | pmc=4721978 | year=2016 | journal=World Journal of Gastroenterology| pages=1433–48 | last1 = Márquez | first1 = M | last2 = Fernández Gutiérrez | first2 = Del Álamo C | last3 = Girón-González | first3 = JA}}
13. ^1 {{cite journal|vauthors=Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM|title=Intestinal permeability--a new target for disease prevention and therapy|journal=BMC Gastroenterology|volume=14|page=189|date=Nov 18, 2014|pmid=25407511|pmc=4253991|doi=10.1186/s12876-014-0189-7|type=Review}}
14. ^1 {{cite journal| vauthors=Viggiano D, Ianiro G, Vanella G, Bibbò S, Bruno G, Simeone G et al.| title=Gut barrier in health and disease: focus on childhood | journal=European Review for Medical and Pharmacological Sciences| year= 2015 | volume= 19 | issue= 6 | pages= 1077–85 | pmid=25855935 | url=http://www.europeanreview.org/wp/wp-content/uploads/1077-1085.pdf}}
15. ^{{cite journal|vauthors=Yeoh N, Burton JP, Suppiah P, Reid G, Stebbings S|title=The role of the microbiome in rheumatic diseases|journal=Current Rheumatology Reports|volume=15|issue=3|page=314|date=Mar 2013|pmid=23378145|doi=10.1007/s11926-012-0314-y|type=Review}}
16. ^1 2 3 4 {{cite journal |vauthors=Rapin JR, Wiernsperger N |title=Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine |journal=Clinics|volume=65 |issue=6 |pages=635–43 |year=2010 |pmid=20613941 |pmc=2898551 |doi=10.1590/S1807-59322010000600012 |type=Review}}
17. ^{{cite journal| vauthors=Yarandi SS, Peterson DA, Treisman GJ, Moran TH, Pasricha PJ| title=Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases | journal=Journal of Neurogastroenterology and Motility| year= 2016 | volume= 22 | issue= 2 | pages= 201–12 | pmid=27032544 | doi=10.5056/jnm15146 | pmc=4819858 | type=Review | quote=In patients with schizophrenia, there are increased intestinal permeability and change in intestinal function}}
18. ^{{cite journal| vauthors=Severance EG, Yolken RH, Eaton WW| title=Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling | journal=Schizophrenia Research| year= 2016 | volume= 176 | issue= 1 | pages= 23–35 | pmid=25034760 | doi=10.1016/j.schres.2014.06.027 | pmc=4294997 | type=Review }}
19. ^{{cite journal |vauthors=Teixeira TF, Collado MC, Ferreira CL, Bressan J, Peluzio Mdo C |title=Potential mechanisms for the emerging link between obesity and increased intestinal permeability |journal=Nutrition Research|volume=32 |issue=9 |pages=637–47 | date=September 2012 |pmid=23084636 |doi=10.1016/j.nutres.2012.07.003 |type=Review }}
20. ^{{cite journal |vauthors=Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A |title=Gut microbiota and metabolic syndrome |journal=World Journal of Gastroenterology|volume=20 |issue=43 |pages=16079–16094 | date=November 2014 |pmid=25473159 |pmc=4239493 |doi=10.3748/wjg.v20.i43.16079 |type=Review}}
21. ^{{cite journal|pmid=15154150|year=2004|last1=Kiefer|first1=D|last2=Ali-Akbarian|first2=L|title=A brief evidence-based review of two gastrointestinal illnesses: Irritable bowel and leaky gut syndromes|volume=10|issue=3|pages=22–30; quiz 31, 92|journal=Alternative Therapies in Health and Medicine}}
22. ^{{cite journal|vauthors=Rao M, Gershon MD |title= The bowel and beyond: the enteric nervous system in neurological disorders |journal= Nature Reviews Gastroenterology & Hepatology|volume= 13|issue= 9|pages= 517–28|date=September 2016 |pmid=27435372 |pmc=5005185 |doi= 10.1038/nrgastro.2016.107|url= |type=Review}}
23. ^1 2 {{cite journal |vauthors=Heyman M, etal | date = Sep 2012 | title = Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis | journal = Gut| volume = 61 | issue = 9| pages = 1355–64 | doi = 10.1136/gutjnl-2011-300327 | pmid = 21890812 | type = Review | quote= Changes in intestinal paracellular and transcellular permeability appear secondary to the abnormal immune reaction induced by gluten. Gliadin was suggested to increase junction permeability to small molecules through the release of prehaptoglobin-2. Environmental triggers of CD other than gliadin may also promote changes in permeability. Intestinal infection and iron deficiency can stimulate the expression of the transferrin receptor (TfR) CD71 in enterocytes. ... Once established, the alterations in intestinal permeability, notably the retro-transport of IgA-gliadin peptides, might self-sustain the inflammatory immune responses and perpetuate a vicious circle.}}
24. ^1 {{Cite journal|last=Khaleghi|first=Shahryar|last2=Ju|first2=Josephine M.|last3=Lamba|first3=Abhinav|last4=Murray|first4=Joseph A.|date= Jan 2016 |title=The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate|journal=Therapeutic Advances in Gastroenterology|volume=9|issue=1|pages=37–49|doi=10.1177/1756283X15616576|pmc=4699279|pmid=26770266 | type=Review. Research Support, N.I.H., Extramural}}
25. ^{{cite journal| author=Fasano A| title=Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications | journal=Clinical Gastroenterology and Hepatology| year= 2012 | volume= 10 | issue= 10 | pages= 1096–100 | pmid=22902773 | doi=10.1016/j.cgh.2012.08.012 | pmc=3458511 | type=Review }}
26. ^{{cite journal|last1=Akobeng|first1=AK|last2=Elawad|first2=M|last3=Gordon|first3=M|title=Glutamine for induction of remission in Crohn's disease.|journal=Cochrane Database of Systematic Reviews|date=8 February 2016|volume=2|pages=CD007348|pmid=26853855|doi=10.1002/14651858.CD007348.pub2|url=http://clok.uclan.ac.uk/13855/1/__lha-022_pers-I_00068E5E_My%20Documents_Akobeng_et_al-2016-The_Cochrane_library.pdf}}
27. ^1 {{cite journal | vauthors=Lopetuso LR, Scaldaferri F, Bruno G, Petito V, Franceschi F, Gasbarrini A | title=The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors | journal= European Review for Medical and Pharmacological Sciences| volume=19 | issue=6 | pages=1068–1076 | year=2015 | url=https://www.europeanreview.org/article/8706 | pmid = 25855934 }}
28. ^{{cite journal | vauthors=Ganesan K, Chung SK, Vanamala J, Xu B | title=Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes | journal= International Journal of Molecular Sciences| volume=19 | issue=12 | pages=E3720 | year=2018 | doi=10.3390/ijms19123720 | pmc=6320976 | pmid = 30467295 }}
29. ^{{cite journal |vauthors=Crespo Pérez L, etal | date = Jan 2012 | title = Non-dietary therapeutic clinical trials in coeliac disease | url = | journal = European Journal of Internal Medicine| volume = 23 | issue = 1| pages = 9–14 | doi = 10.1016/j.ejim.2011.08.030 | pmid = 22153524 | type = Review}}
30. ^1 2 {{cite web|url=http://www.nhs.uk/conditions/leaky-gut-syndrome/|title=Leaky gut syndrome|date=26 February 2015|publisher=NHS Choices|accessdate=15 August 2016}}
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