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- Fictional characters
Isaacs is a surname. Notable people with the surname include: - Alick Isaacs, British virologist
- Avrom Isaacs, Canadian art dealer
- Bertha Isaacs, Bahamian women's tennis player and women's rights activist
- David Isaacs, American screenwriter
- Erwin Isaacs, South African football (soccer) player
- George Isaacs, British politician and trades unionist
- Gregory Isaacs, Jamaican reggae musician
- Iorrie Isaacs, Wales international rugby player
- Sir Isaac Isaacs, Australian politician, jurist and Governor-General
- Jason Isaacs, British actor
- Jeremy Isaacs, British television producer and executive
- John Isaacs, African-American professional basketball player
- John Dove Isaacs, American oceanic scientist
- Jorge Isaacs, Colombian writer, politician and soldier
- Rt Hon Sir Kendal Isaacs QC, Bahamian politician and Leader of the Opposition
- Levi Isaacs (1860–1913), Australian tobacconist and Jewish lay leader
- Lewis Henry Isaacs, English architect, surveyor, and politician
- Nathaniel Isaacs, British adventurer
- Pamela Isaacs, American actress and singer
- Rufus Isaacs, 1st Marquess of Reading, English politician and jurist
- Rufus Isaacs (game theorist), American mathematician
- Sonya Isaacs, American country singer
- Stan Isaacs, American sportswriter
- Susan Isaacs, American novelist and screenwriter
- Susan Sutherland Isaacs, British educational psychologist and psychoanalyst
- Susie Isaacs, American professional poker player
Fictional characters- Jeff Isaacs, from Degrassi: The Next Generation
- Doctor Sam Isaacs, from Resident Evil (film)
- Toby Isaacs, from Degrassi: The Next Generation
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