词条 | Kallidin |
释义 |
| Watchedfields = changed | verifiedrevid = 405924903 | ImageFile=Kallidin.svg | ImageSize=200px | ImageFile2=Kallidin 3D.png | ImageSize2=200px | IUPACName= L-Lysyl-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine | OtherNames= |Section1={{Chembox Identifiers | IUPHAR_ligand = 650 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4470640 | InChI = 1/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | InChIKey = FYSKZKQBTVLYEQ-FSLKYBNLBR | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FYSKZKQBTVLYEQ-FSLKYBNLSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=342-10-9 | PubChem = 5311111 | SMILES = O=C(N[C@H](C(=O)N[C@H](C(=O)O)CCC/N=C(\)N)Cc1ccccc1)[C@H]5N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]3N(C(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CCC/N=C(\)N)CCC2)CCC3)Cc4ccccc4)CO)CCC5 | MeSHName=Kallidin |Section2={{Chembox Properties | C=56 | H=85 | N=17 | O=12 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin by the aminopeptidase enzyme. It can be a substrate for carboxypeptidase M and N.[1] Kallidin is identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin receptor. References1. ^{{cite book|author1=Stefan Offermanns|author2=Walter Rosenthal|title=Encyclopedia of Molecular Pharmacology|url=https://books.google.com/books?id=iwwo5gx8aX8C&pg=PA673|accessdate=11 December 2010|year=2008|publisher=Springer|isbn=978-3-540-38916-3|pages=673–}} {{Autacoids}}{{Peptidergics}}{{Biochem-stub}} 2 : Peptides|Kinin–kallikrein system |
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