Kami-sama may refer to:

• {{nihongo|Kami-sama|神様}}, the Japanese word for "deity"
• {{nihongo|The Almighty (Oh My Goddess!)|神様|Kami-sama}}, the ruler of Heaven and Earth in Oh My Goddess!
• Kami-sama (Saiyuki), a character who is a servant to Ukoku Sanzo/Dr. Nii Jianyi in Saiyuki
• {{nihongo|Kami-sama|神様|Kami-sama}}, the deity who rules over the galactic system which surrounds Earth in Dr. Slump
• {{nihongo|Kami or Kami-sama|神様|Kami-sama}}, a deity in Dragon Ball who is the God of Earth
• Kamisama (novel), a 1994 novel by Hiromi Kawakami

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